• Publications
  • Influence
GCN5-related N-acetyltransferases: a structural overview.
Hundreds of acetyltransferases exist. All use a common acetyl donor--acetyl coenzyme A--and each exhibits remarkable specificity for acetyl acceptors, which include small molecules and proteins.Expand
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The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland.
A remarkably constant feature of vertebrate physiology is a daily rhythm of melatonin in the circulation, which serves as the hormonal signal of the daily light/dark cycle: melatonin levels areExpand
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Crystal Structure of the 14-3-3ζ:Serotonin N-Acetyltransferase Complex A Role for Scaffolding in Enzyme Regulation
Serotonin N-acetyltransferase (AANAT) controls the daily rhythm in melatonin synthesis. When isolated from tissue, AANAT copurifies with isoforms epsilon and zeta of 14-3-3. We have determined theExpand
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Photoneural regulation of the mammalian pineal gland.
  • D. Klein
  • Chemistry, Medicine
  • Ciba Foundation symposium
  • 1985
Mammalian pineal function appears to be controlled primarily through the release of noradrenaline from the terminals of nerves whose cell bodies lie in the superior cervical ganglia. This is theExpand
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Melatonin production: proteasomal proteolysis in serotonin N-acetyltransferase regulation.
The nocturnal increase in circulating melatonin in vertebrates is regulated by 10- to 100-fold increases in pineal serotonin N-acetyltransferase (AA-NAT) activity. Changes in the amount of AA-NATExpand
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Arylalkylamine N-Acetyltransferase: “the Timezyme”*
  • D. Klein
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 16 February 2007
Arylalkylamine N-acetyltransferase controls daily changes in melatonin production by the pineal gland and thereby plays a unique role in biological timing in vertebrates. ArylalkylamineExpand
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Characterization of the chicken serotonin N-acetyltransferase gene. Activation via clock gene heterodimer/E box interaction.
The abundance of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) mRNA in the chicken pineal gland exhibits a circadian rhythm, which is translated into a circadian rhythm inExpand
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Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation
Abstract. The large daily rhythm in circulating melatonin levels is a highly conserved feature of vertebrate physiology: high values always occur at night. The dynamics of the rhythm are controlledExpand
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Visual pathways and the central neural control of a circadian rhythm in pineal serotonin N-acetyltransferase activity.
Abstract The pineal enzyme, serotonin N-acetyltransferase, exhibits a circadian rhythm of activity with nocturnal levels 15–30 times greater than those observed during a light period in the rat. ThisExpand
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Zebrafish serotonin N-acetyltransferase-2: marker for development of pineal photoreceptors and circadian clock function.
Serotonin N-acetyltransferase (AANAT), the penultimate enzyme in melatonin synthesis, is typically found only at significant levels in the pineal gland and retina. Large changes in the activity ofExpand
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