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Pharmacological analysis of cyclooxygenase-1 in inflammation.
The enzymes cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs and thromboxane. These lipid mediatorsExpand
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Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
Nature 384, 644-648 (1996) We omitted to cite an earlier report on (human) cyclooxygenase-2 structure by C. Luong et al.1.
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Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.
We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the subcutaneous rat air pouch induces a rapid inflammatory responseExpand
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Nitric oxide activates cyclooxygenase enzymes.
We have evaluated the role of nitric oxide (NO) on the activity of the constitutive and induced forms of cyclooxygenase (COX; COX-1 and COX-2, respectively). Induction of NO synthase (NOS) and COXExpand
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Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.
Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used for the treatment of inflammatory diseases, but significant side effects such as gastrointestinal erosion and renal damage limit theirExpand
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Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide
A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and in vivo. Extensive structure-activityExpand
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Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors.
We provide evidence that cyclooxygenase (COX)-2-derived prostaglandins contribute to tumor growth by inducing newly formed blood vessels (neoangiogenesis) that sustain tumor cell viability andExpand
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Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
PROSTAGLANDINSand glucocorticoids are potent mediators of inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) exert their effects by inhibition of prostaglandin production. TheExpand
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Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase.
The enzyme cyclo-oxygenase catalyses the oxygenation of arachidonic acid, leading to the formation of prostaglandins. Recently two forms of cyclo-oxygenase have been described: a constitutive (COX-1)Expand
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The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.
We report here that the bacterial lipopolysaccharide endotoxin induces human blood monocytes in a time- and dose-dependent manner to release prodigious amounts of prostaglandins with thromboxane A2,Expand
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