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Regulation of Immune Responses by Prostaglandin E2
  • P. Kalinski
  • Medicine, Biology
  • The Journal of Immunology
  • 1 January 2012
Targeting the production, degradation, and responsiveness to PGE2 provides tools to modulate the patterns of immunity in a wide range of diseases, from autoimmunity to cancer. Expand
T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal.
It is suggested that migrating DCs carry an additional ‘signal 3', contributing to the initial commitment of naive Th cells into Th1 or Th2 subsets. Expand
alpha-type-1 polarized dendritic cells: a novel immunization tool with optimized CTL-inducing activity.
Serum-free generation of alphaDC1 allows, for the first time, the clinical application of DCs that combine the key three features important for their efficacy as anticancer vaccines. Expand
IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells.
It is suggested that elevated levels of PGE2 promote type 2 Th responses by stably impairing the ability of maturing DC to produce IL-12, and may be considered for use in immunotherapy. Expand
Development of Th1-Inducing Capacity in Myeloid Dendritic Cells Requires Environmental Instruction1
It is shown that neither a Th1- nor a Th2-inducing function is an intrinsic attribute of human myeloid DC, but both depend on environmental instruction and are resistant to further modulation, which may facilitate their potential use in immunotherapy. Expand
Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells.
The establishment of a positive feedback loop between prostaglandin E (2) (PGE(2)) and cyclooxygenase 2 (COX2), the key regulator of PGE(2) synthesis, represents the determining factor in redirecting the development of CD1a(+) DCs to CD14(+) CD33(+)CD34(+) monocytic MDSCs. Expand
IL-18–induced CD83+CCR7+ NK helper cells
Independent regulation of the “helper” versus “effector” pathways of NK cell differentiation and novel mechanisms of immunoregulation by IL-18 and PGE2 are demonstrated. Expand
Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer.
Prostaglandin E(2) (PGE(2), an inflammatory mediator with a previously known Th2-driving function, dose-dependently enhances the IL-12p40 mRNA expression and the secretion of IL- 12p40 protein in human tumor necrosis factor-alpha (TNFalpha)-stimulated immature dendritic cells (DCs). Expand
Microbial Compounds Selectively Induce Th1 Cell-Promoting or Th2 Cell-Promoting Dendritic Cells In Vitro with Diverse Th Cell-Polarizing Signals1
The data suggest that the molecular basis of Th1/Th2 polarization via DCs is unexpectedly diverse and is adapted to the nature of the microbial compounds. Expand
PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment.
This work shows that in ascites isolated from ovarian cancer patients, both CXCL12 and CXCR4 are controlled by the tumor-associated inflammatory mediator prostaglandin E(2) (PGE(2)), which attracts myeloid-derived suppressor cells (MDSC) into the ascites microenvironment, providing a powerful rationale to target PGE(2), signaling in ovarian cancer therapy. Expand