• Publications
  • Influence
Biologic basis for interleukin-1 in disease.
TLDR
This is a lengthy review, with 586 citations chosen to illustrate specific areas of interest rather than a compendium of references, which summarizes what the author considers established or controversial topics linking the biology of IL-1 to mechanisms of disease. Expand
Immunological and inflammatory functions of the interleukin-1 family.
  • C. Dinarello
  • Biology, Medicine
  • Annual review of immunology
  • 20 March 2009
TLDR
The IL-1 family includes members that suppress inflammation, both specifically within the IL-2 family but also nonspecifically for TLR ligands and the innate immune response. Expand
Neuroinflammation in Alzheimer's disease
TLDR
Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction. Expand
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.
TLDR
This review summarizes acute and chronic inflammatory diseases that are treated by reducing IL-1β activity and proposes that disease severity is affected by the anti-inflammatory members of the IL- 1 family of ligands and receptors. Expand
Proinflammatory cytokines.
TLDR
It remains difficult to identify those patients who would benefit from anticytokine therapy for septic shock, and it should be able to "rescue" the patient whose condition continues to deteriorate in the face of considerable support efforts. Expand
The interleukin-1 family: back to the future.
TLDR
The key properties of IL-1 family members are reviewed, with emphasis on pathways of negative regulation and orchestration of innate and adaptive immunity. Expand
Interleukin-1 and interleukin-1 antagonism.
TLDR
The recent cloning of a naturally occurring IL-1 receptor antagonist (IL-1ra) has opened new experimental and clinical approaches and reduced the severity of diseases such as hemodynamic shock, lethal sepsis, inflammatory bowel disease, experimental arthritis, and the spontaneous proliferation of human leukemic cells. Expand
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
TLDR
Monotherapy blocking IL-1 activity in autoinflammatory syndromes results in a rapid and sustained reduction in disease severity, including reversal of inflammation-mediated loss of sight, hearing and organ function. Expand
The interleukin‐1 family: 10 years of discovery 1
  • C. Dinarello
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1 December 1994
TLDR
Ten years ago the cloning of IL‐1 resolved the question of whether a single polypeptide could evoke a wide variety of biological effects and opened other avenues of fundamental biological interest. Expand
Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages.
TLDR
It is demonstrated that human blood monocytes release processed IL-1beta after a one-time stimulation with either TLR2 or TLR4 ligands, resulting from constitutively activated caspase-1 and release of endogenous adenosine triphosphate. Expand
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