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Regulation of lung injury and repair by Toll-like receptors and hyaluronan
Mechanisms that regulate inflammation and repair after acute lung injury are incompletely understood. The extracellular matrix glycosaminoglycan hyaluronan is produced after tissue injury andExpand
Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites1
Fibrocytes are a distinct population of blood-borne cells that display a unique cell surface phenotype (collagen I+/CD11b+/CD13+/CD34+/CD45RO+/MHC class II+/CD86+) and exhibit potentExpand
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
The cytokine macrophage migration inhibitory factor (MIF) plays a critical role in inflammatory diseases and atherogenesis. We identify the chemokine receptors CXCR2 and CXCR4 as functional receptorsExpand
Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair
BackgroundThe host response to tissue injury requires a complex interplay of diverse cellular, humoral, and connective tissue elements. Fibroblasts participate in this process by proliferating withinExpand
The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor
For over 25 years, the cytokine known as macrophage migration inhibitory factor (MIF) has been considered to be a product of activated T lymphocytes. We recently identified the murine homolog ofExpand
MIF Signal Transduction Initiated by Binding to CD74
Macrophage migration inhibitory factor (MIF) accounts for one of the first cytokine activities to have been described, and it has emerged recently to be an important regulator of innate and adaptiveExpand
MIF as a glucocorticoid-induced modulator of cytokine production
GLUCOCORTICOID hormones are important for vital functions and act to modulate inflammatory and immune responses1,2. Yet, in contrast to other hormonal systems, no endogenous mediators have beenExpand
Circulating fibrocytes: collagen-secreting cells of the peripheral blood.
Since the original description of circulating fibrocytes in 1994, our knowledge of this unique cell population has grown steadily. While initially described in the context of wound repair, fibrocytesExpand
CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex.
The macrophage migration inhibitory factor (MIF) receptor (CD74) was cloned recently, but the signaling mechanism is not evident. We hypothesized that signaling requires an additional molecule suchExpand
Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy.
Endogenous advanced glycation endproducts (AGEs) include chemically crosslinking species (glycotoxins) that contribute to the vascular and renal complications of diabetes mellitus (DM). RenalExpand