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Pregnanolone

Known as: 3-Hydroxypregnan-20-one, Pregnan-20-one, 3-hydroxy-, (3alpha,5beta)-, 3 alpha-Hydroxy-5 beta-pregnan-20-one 
A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.
National Institutes of Health

Related topics

Related topics

28 relations

Narrower (14)

17,20-dihydroxypregnan-3-one17-hydroxypregnanolone3-hydroxypregnan-3-one 3-sulfateCo 134444

Broader (2)

AnestheticsPregnanes
In BloodPregnanolone, (3beta, 5alpha)-isomerPregnanolone, (3beta, 5beta)-isomerProcess of secretion

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Effects of progesterone administration and APPswe+PSEN1Δe9 mutation for cognitive performance of mid-aged mice
Highly Cited
2006
Highly Cited
2006
High-Affinity, Slowly Desensitizing GABAA Receptors Mediate Tonic Inhibition in Hippocampal Dentate Granule Cells
The tonic form of GABA-mediated inhibition requires the presence of slowly desensitizing GABAA receptors with high affinity… 
Highly Cited
2002
Highly Cited
2002
Allopregnanolone attenuates N-methyl-d-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture
Highly Cited
2000
Highly Cited
2000
Neurosteroid Modulation of GABA IPSCs Is Phosphorylation Dependent
The neurosteroid 3α-hydroxy-5α-pregnan-20-one (allopregnanolone) facilitates GABAAreceptor-mediated ionic currents via allosteric… 
Highly Cited
2000
Highly Cited
2000
Olanzapine increases allopregnanolone in the rat cerebral cortex
Highly Cited
1998
Highly Cited
1998
The role of GABA-A and mitochondrial diazepam-binding inhibitor receptors on the effects of neurosteroids on food intake in mice
Abstract The present studies were undertaken to investigate the neuroactive steroidal modulation of feeding behavior and possible… 
Highly Cited
1996
Highly Cited
1996
Role of endothelium in the vasodilating effect of progestins and androgens on the rat thoracic aorta.
Highly Cited
1990
Highly Cited
1990
Pregnanolone emulsion A preliminary pharmacokinetic and pharmacodynamic study of a new intravenous anaesthetic agent
Pregnanolone emulsion, a new steroid anaesthetic agent, was administered intravenously as bolus doses to six young healthy male… 
Highly Cited
1965
Highly Cited
1965
STUDIES OF LYSOSOMES. VI. THE EFFECT OF NEUTRAL STEROIDS AND BILE ACIDS ON LYSOSOMES IN VITRO.
Highly Cited
1961
Highly Cited
1961
An investigation of the urinary metabolites and secretion rates of aldosterone and cortisol in man and a description of methods for their measurement.
Methods suitable for the estimation of urinary metabolites of aldosterone and of cortisol are described. The excretion of 3H and… 
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