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Pregnanolone

Known as: 3-Hydroxypregnan-20-one, Pregnan-20-one, 3-hydroxy-, (3alpha,5beta)-, 3 alpha-Hydroxy-5 beta-pregnan-20-one 
A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.
National Institutes of Health

Papers overview

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Review
2015
Review
2015
The Twelfth Eilat Conference on New Antiepileptic Drugs (AEDs) - EILAT XII, took place in Madrid, Spain from August 31st to… Expand
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Highly Cited
2006
Highly Cited
2006
Inhibitory neurotransmission mediated by GABAA receptors can be modulated by the endogenous neurosteroids, allopregnanolone and… Expand
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Highly Cited
2005
Highly Cited
2005
This report compares the effects of progesterone and its metabolite, allopregnanolone, on the early injury cascade (apoptosis… Expand
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Highly Cited
2004
Highly Cited
2004
Following a traumatic brain injury (TBI), the excessive release of interleukin-1beta (IL-1beta) and tumor necrosis factor alpha… Expand
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Highly Cited
2002
Highly Cited
2002
Some neurosteroids have been shown to display beneficial effects on neuroprotection in rodents. To investigate the… Expand
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Highly Cited
2000
Highly Cited
2000
Neuroactive steroids are synthesized de novo in brain, yet their physiological significance remains elusive. We provide… Expand
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Highly Cited
1999
Highly Cited
1999
The neurosteroid 3alpha-hydroxysteroid-5alpha-pregnan-20-one (allopregnanolone) acts as a positive allosteric modulator of gamma… Expand
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Highly Cited
1998
Highly Cited
1998
The relation between changes in brain and plasma concentrations of neurosteroids and the function and structure of gamma… Expand
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Highly Cited
1995
Highly Cited
1995
Previous studies from this laboratory have shown that progesterone (PROG) treatment in ovariectomized rats produces an anti… Expand
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Highly Cited
1991
Highly Cited
1991
A 3 alpha-hydroxy A-ring-reduced metabolite of progesterone, 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone), and one… Expand
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