Pregnanolone

Known as: 3-Hydroxypregnan-20-one, Pregnan-20-one, 3-hydroxy-, (3alpha,5beta)-, 3 alpha-Hydroxy-5 beta-pregnan-20-one 
A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Our previous analyses showed that allopregnanolone (APalpha) significantly increased proliferation of rodent and human neural… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2009
Highly Cited
2009
BACKGROUND Niemann-Pick type C (NPC) disease is a fatal neurodegenerative disorder caused most commonly by a defect in the NPC1… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
This report compares the effects of progesterone and its metabolite, allopregnanolone, on the early injury cascade (apoptosis… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Our previous research demonstrated that the neuroactive progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Niemann–Pick type C (NP-C) disease is a fatal, autosomal recessive, childhood neurodegenerative disease. The NP-C mouse… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Following a traumatic brain injury (TBI), the excessive release of interleukin-1beta (IL-1beta) and tumor necrosis factor alpha… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Some neurosteroids have been shown to display beneficial effects on neuroprotection in rodents. To investigate the… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
The effects of social isolation on behavior, neuroactive steroid concentrations, and GABA(A) receptor function were investigated… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
The relation between changes in brain and plasma concentrations of neurosteroids and the function and structure of gamma… (More)
  • figure 1
  • figure 3
  • figure 2
  • table 1
  • table 2
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Previous studies from this laboratory have shown that progesterone (PROG) treatment in ovariectomized rats produces an anti… (More)
Is this relevant?