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Androstenedione production and interconversion rates measured in peripheral blood and studies on the possible site of its conversion to testosterone.
REVIEW: THE USE OF ISOTOPIC STEROIDS FOR THE MEASUREMENT OF PRODUCTION RATES IN VIVO.
- J. Tait
- Chemistry, Medicine
- The Journal of clinical endocrinology and…
- 1 December 1963
The most obvious purpose of the use of isotopic steroids to obtain secretion rates in vivohas been to minimize the disturbance caused by the observation to the prevailing secretion rate. This is more… Expand
Linkage of Chromosomal Markers on 4q With a Putative Gene Determining Maximal Insulin Action in Pima Indians
Findings indicate that a gene on 4q, near the FABP2 and ANX5 loci, contributes to in vivo insulin action in Pima Indians. Expand
In vitro effects of ACTH, angiotensins, serotonin and potassium on steroid output and conversion of corticosterone to aldosterone by isolated adrenal cells.
Microscopic examination and consideration of steroid outputs suggest that preparations from decapsulated glands consist of zona fasciculata-reticularis cells, while those from capsular glands consist mainly of zzon glomerulosa cells with some zzon fascicULata contamination. Expand
The metabolic clearance rate of progesterone in males and ovariectomized females.
It can be shown that after a single injection or continuous infusion of radioactive steroid, the metabolic clearance rate can be calculated as the reciprocal of the integrated plasma concentration of radioactivity measured specifically as the hormone. Expand
The properties of adrenal zona glomerulosa cells after purification by gravitational sedimentation
- J. Tait, S. Tait, R. Gould, M. Mee
- Biology, Medicine
- Proceedings of the Royal Society of London…
- 26 February 1974
The maximal response of the purified zona glomerulosa cells to cyclic AMP is similar to that elicited by valine and isoleucine angiotensin II, potassium, serotonin or ACTH, which indicates that if these stimuli act by increasing cyclicAMP output, then the maximum response of corticosterone output (about twofold) is defined by the limitedresponse of the biosynthetic pathways to cycling AMP. Expand
The metabolic clearance rate of aldosterone in pregnant and nonpregnant subjects estimated by both single-injection and constant-infusion methods.
The singleinjection and constant-infusion methods for estimating the MCR are compared for both pregnant and nonpregnant subjects and suggest that the over-all metabolism of aldosterone is unchanged in pregnancy. Expand
The disappearance of 7-H-3-d-aldosterone in the plasma of normal subjects.
The study of the disappearance of the radioactivity in plasma after the injection of labeled aldosterone should elucidate the transport and metabolism of this steroid in man. In particular this would… Expand
Production of steroids by in vitro superfusion of endocrine tissue. 3. Corticosterone output from rat adrenals stimulated by adrenocorticotropin or cyclic 3',5'-adenosine monophosphate and the…
Dose response curves for adrenals (H) showed that higher concentrations of continuously infused ACH increased corticosterone output rate 13-fold within 1 hr almost to that of Adrenals (I) similarly infused, which were not attributable to irreversible changes in the tissue during superfusion. Expand