Pregnanes

Known as: pregnane compound, Pregnane, Pregnanes [Chemical/Ingredient] 
Saturated derivatives of the steroid pregnane. The 5-beta series includes PROGESTERONE and related hormones; the 5-alpha series includes forms… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
The pregnane X receptor is a ligand-activated transcription factor that is abundantly expressed in hepatocytes. Numerous drugs… (More)
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Review
2008
Review
2008
Human cytochrome P450 (CYP) 3A4 is the most abundant hepatic and intestinal phase I enzyme that metabolizes approximately 50… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Oral estrogen therapy increases the risk of venous thromboembolism (VTE) in postmenopausal women. Transdermal estrogen… (More)
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2007
2007
Three new pregnanes, 21-hydroxypregna-4,6-diene-3,12,20-trione (1), 20R-hydroxypregna-4,6-diene-3,12-dione (2), and 16beta,17beta… (More)
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2006
2006
BACKGROUND & AIMS The activated pregnane X receptor is antifibrogenic in rodent chronic liver injury in vivo models. The aim of… (More)
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Highly Cited
2005
Highly Cited
2005
Bile acids, steroids, and drugs activate steroid and xenobiotic receptor pregnane X receptor (PXR; NR1I2), which induces human… (More)
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Review
2003
Review
2003
The metabolic nuclear receptors act as metabolic and toxicological sensors, enabling the organism to quickly adapt to… (More)
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Highly Cited
2003
Highly Cited
2003
Estrogen has been shown to contribute greatly to growth and development in endometrial cancer. And recent research has suggested… (More)
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Highly Cited
2002
Highly Cited
2002
The elucidation of the individual contributions of the four CYP3A genes to the overall CYP3A activity has been hampered by… (More)
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Highly Cited
1998
Highly Cited
1998
Steroid hormones exert profound effects on differentiation, development, and homeostasis in higher eukaryotes through… (More)
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