• Publications
  • Influence
The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
The elevated plus maze is a widely used behavioral assay for rodents and it has been validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones, and to define brainExpand
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Ovarian steroids enhance object recognition in naturally cycling and ovariectomized, hormone-primed rats
Learning and memory processes may be influenced by fluctuations in steroid hormones, such as estrogens and progestins. In this study, we have used an animal model to investigate the effects ofExpand
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Withdrawal from 3alpha-OH-5alpha-pregnan-20-One using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated current and increases the GABAA receptor alpha4 subunit in association
In the present study, we have characterized properties of steroid withdrawal using a pseudopregnant rat model. This paradigm results in increased production of endogenous progesterone from ovarianExpand
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Estrus-associated decrements in a water maze task are limited to acquisition
  • C. Frye
  • Psychology, Medicine
  • Physiology & Behavior
  • 31 January 1995
To ascertain whether gonadal hormones have activational influences on spatial ability, the relationship between estrous cycle, sex differences and water maze performance was examined in two studies.Expand
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Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3α,5α-THP
Sex differences and estrous cycle variations in anxiolytic-like behaviors and progestin concentrations were examined. Proestrous (n=22), estrous (n=19), diestrous (n=20), and male (n=18) Long–EvansExpand
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Endocrine Disrupters: A Review of Some Sources, Effects, and Mechanisms of Actions on Behaviour and Neuroendocrine Systems
Some environmental contaminants interact with hormones and may exert adverse consequences as a result of their actions as endocrine disrupting chemicals (EDCs). Exposure in people is typically aExpand
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ERβ-Selective Estrogen Receptor Modulators Produce Antianxiety Behavior when Administered Systemically to Ovariectomized Rats
  • A. Walf, C. Frye
  • Psychology, Medicine
  • Neuropsychopharmacology
  • 1 September 2005
17β-Estradiol (E2) may influence anxiety behavior; however, its effects and mechanisms are not well understood. To determine whether E2's effects on anxiety behavior may involve actions atExpand
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Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task
Steroid modulation of cognitive function has focused on estrogen (E(2)), but progestins naturally co-vary with E(2) and may also influence cognitive performance. Spatial performance in the objectExpand
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Withdrawal from 3α-OH-5α-Pregnan-20-One Using a Pseudopregnancy Model Alters the Kinetics of Hippocampal GABAA-Gated Current and Increases the GABAAReceptor α4 Subunit in Association with Increased
In the present study, we have characterized properties of steroid withdrawal using a pseudopregnant rat model. This paradigm results in increased production of endogenous progesterone from ovarianExpand
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Responses to Laboratory Psychosocial Stress in Postpartum Women
Objective Lactation has been associated with attenuated hormonal responses to exercise stress in humans. This study was designed to determine the effect of lactation on hypothalamic-pituitary-adrenalExpand
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