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In vitro effects of ACTH, angiotensins, serotonin and potassium on steroid output and conversion of corticosterone to aldosterone by isolated adrenal cells.
Microscopic examination and consideration of steroid outputs suggest that preparations from decapsulated glands consist of zona fasciculata-reticularis cells, while those from capsular glands consist mainly of zzon glomerulosa cells with some zzon fascicULata contamination.
The metabolic clearance rate of progesterone in males and ovariectomized females.
It can be shown that after a single injection or continuous infusion of radioactive steroid, the metabolic clearance rate can be calculated as the reciprocal of the integrated plasma concentration of radioactivity measured specifically as the hormone.
The properties of adrenal zona glomerulosa cells after purification by gravitational sedimentation
- J. Tait, S. Tait, R. Gould, M. Mee
- BiologyProceedings of the Royal Society of London…
- 26 February 1974
The maximal response of the purified zona glomerulosa cells to cyclic AMP is similar to that elicited by valine and isoleucine angiotensin II, potassium, serotonin or ACTH, which indicates that if these stimuli act by increasing cyclicAMP output, then the maximum response of corticosterone output (about twofold) is defined by the limitedresponse of the biosynthetic pathways to cycling AMP.
The metabolic clearance rate of aldosterone in pregnant and nonpregnant subjects estimated by both single-injection and constant-infusion methods.
- J. Tait, B. Little, S. Tait, C. Flood
- Biology, MedicineThe Journal of clinical investigation
- 1 December 1962
The singleinjection and constant-infusion methods for estimating the MCR are compared for both pregnant and nonpregnant subjects and suggest that the over-all metabolism of aldosterone is unchanged in pregnancy.
Aldosterone secretion and metabolism in normal men and women and in pregnancy.
Production of steroids by in vitro superfusion of endocrine tissue. 3. Corticosterone output from rat adrenals stimulated by adrenocorticotropin or cyclic 3',5'-adenosine monophosphate and the…
Dose response curves for adrenals (H) showed that higher concentrations of continuously infused ACH increased corticosterone output rate 13-fold within 1 hr almost to that of Adrenals (I) similarly infused, which were not attributable to irreversible changes in the tissue during superfusion.
The disappearance of 7-H-3-d-aldosterone in the plasma of normal subjects.
The study of the disappearance of the radioactivity in plasma after the injection of labeled aldosterone should elucidate the transport and metabolism of this steroid in man. In particular this would…
Some studies on the biosynthesis of aldosterone and other adrenal steroids.
The effects of potassium, 5-hydrocytryptamine, adrenocorticotrophin and angiotensin II on the concentration of adenosine 3':5'-cyclic monophosphate in suspensions of dispersed rat adrenal zona…
The results strongly suggest a link between cyclic AMP production and steroidogenesis in the zone of the adrenal gland that specifically secretes aldosterone.
The metabolism and secretion of aldosterone in elderly subjects.
- C. Flood, C. Gherondache, G. Pincus, J. Tait, S. Tait, S. Willoughby
- Medicine, BiologyThe Journal of clinical investigation
- 1 June 1967
As in patients with mild cardiac dysfunction, the lowered MCR of subjects is due to both reduced splanchnic extraction and blood flow, however, unlike the heart failure patients, in the elderly subjects the plasma concentration of aldosterone is also reduced.