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Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
Olanzapine was the most effective in terms of the rates of discontinuation, and the efficacy of the conventional antipsychotic agent perphenazine appeared similar to that of quetiapine, risperidone, and ziprasidone. Expand
Biological Insights From 108 Schizophrenia-Associated Genetic Loci
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Expand
Genome-wide association study identifies five new schizophrenia loci
The role of common genetic variation in schizophrenia in a genome-wide association study of substantial size is examined, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. Expand
Prevalence of the metabolic syndrome in patients with schizophrenia: Baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison
The metabolic syndrome is highly prevalent in US schizophrenia patients and represents an enormous source of cardiovascular risk, especially for women, so clinical attention must be given to monitoring for this syndrome, and minimizing metabolic risks associated with antipsychotic treatment. Expand
A national study of violent behavior in persons with schizophrenia.
To examine the prevalence and correlates of violence among schizophrenia patients living in the community by developing multivariable statistical models to assess the net effects of psychotic symptoms and other risk factors for minor and serious violence, a large number of patients diagnosed as having schizophrenia were enrolled. Expand
Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis.
Shorter duration of untreated psychosis was associated with greater response to antipsychotic treatment, as measured by severity of global psychopathology, positive symptoms, negative symptoms, and functional outcomes. Expand
Neuropsychology of first-episode schizophrenia: initial characterization and clinical correlates.
A large generalized deficit and more subtle differential deficits were observed even in patients with less severe generalized deficit, but the pattern was unlike the amnestic syndrome and probably reflects different mechanisms. Expand
Practice guideline for the treatment of patients with schizophrenia, second edition.
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders. Expand
Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder.
There is a high rate of relapse within 5 years of recovery from a first episode of schizophrenia and schizoaffective disorder, and this risk is diminished by maintenance antipsychotic drug treatment. Expand