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Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
BACKGROUND The relative effectiveness of second-generation (atypical) antipsychotic drugs as compared with that of older agents has been incompletely addressed, though newer agents are currently usedExpand
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Biological Insights From 108 Schizophrenia-Associated Genetic Loci
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide associationExpand
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Genome-wide association study identifies five new schizophrenia loci
We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and aExpand
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Prevalence of the metabolic syndrome in patients with schizophrenia: Baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison
UNLABELLED One important risk factor for cardiovascular disease is the metabolic syndrome (MS), yet limited data exist on its prevalence in US patients with schizophrenia. METHODS Using baselineExpand
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A national study of violent behavior in persons with schizophrenia.
CONTEXT Violent behavior is uncommon, yet problematic, among schizophrenia patients. The complex effects of clinical, interpersonal, and social-environmental risk factors for violence in thisExpand
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Practice guideline for the treatment of patients with schizophrenia, second edition.
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Neuropsychology of first-episode schizophrenia: initial characterization and clinical correlates.
OBJECTIVE Neuropsychological impairments are well documented in schizophrenia and are important targets of treatment. Information about the severity and pattern of deficits after treatment for theExpand
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Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis.
OBJECTIVE The duration of untreated psychosis may influence response to treatment, reflecting a potentially malleable progressive pathological process. The authors reviewed the literature on theExpand
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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared geneticExpand
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Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs
The treatment of schizophrenia has evolved over the past half century primarily in the context of antipsychotic drug development. Although there has been significant progress resulting in theExpand
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