• Publications
  • Influence
The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
The elevated plus maze is a widely used behavioral assay for rodents and it has been validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones, and to define brainExpand
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Ovarian steroids enhance object recognition in naturally cycling and ovariectomized, hormone-primed rats
Learning and memory processes may be influenced by fluctuations in steroid hormones, such as estrogens and progestins. In this study, we have used an animal model to investigate the effects ofExpand
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ERβ-Selective Estrogen Receptor Modulators Produce Antianxiety Behavior when Administered Systemically to Ovariectomized Rats
  • A. Walf, C. Frye
  • Psychology, Medicine
  • Neuropsychopharmacology
  • 1 September 2005
17β-Estradiol (E2) may influence anxiety behavior; however, its effects and mechanisms are not well understood. To determine whether E2's effects on anxiety behavior may involve actions atExpand
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Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task
Steroid modulation of cognitive function has focused on estrogen (E(2)), but progestins naturally co-vary with E(2) and may also influence cognitive performance. Spatial performance in the objectExpand
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A Review and Update of Mechanisms of Estrogen in the Hippocampus and Amygdala for Anxiety and Depression Behavior
  • A. Walf, C. Frye
  • Psychology, Medicine
  • Neuropsychopharmacology
  • 1 June 2006
Estrogen (E2) has many effects in the central nervous system, including effects on anxiety and depression behavior. This review will address effects of E2 on behaviors related to anxiety andExpand
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Changes in Progesterone Metabolites in the Hippocampus Can Modulate Open Field and Forced Swim Test Behavior of Proestrous Rats
The purpose of these experiments was to test the hypothesis that attenuating the endogenous increase of the 5alpha-reduced progesterone metabolite 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP)Expand
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Estradiol or diarylpropionitrile administration to wild type, but not estrogen receptor beta knockout, mice enhances performance in the object recognition and object placement tasks
Cognitive processes mediated by the hippocampus and cortex are influenced by estradiol (E(2)); however, the mechanisms by which E(2) has these effects are not entirely clear. As such, studies wereExpand
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Antidepressant effects of ERβ-selective estrogen receptor modulators in the forced swim test
Estradiol (E2) may influence depressive symptomology of women and decrease depressive behavior among rodents. The mechanism(s) for E2's antidepressant effects are not well understood. To determineExpand
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Antianxiety and Antidepressive Behavior Produced by Physiological Estradiol Regimen may be Modulated by Hypothalamic–Pituitary–Adrenal Axis Activity
  • A. Walf, C. Frye
  • Psychology, Medicine
  • Neuropsychopharmacology
  • 1 July 2005
Variations in estradiol (E2) may influence expression of stress-related anxiety and depression symptoms among women. Effects of E2 and stress on anxiety and depressive behavior were investigatedExpand
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Estrogen and/or progesterone administered systemically or to the amygdala can have anxiety-, fear-, and pain-reducing effects in ovariectomized rats.
  • C. Frye, A. Walf
  • Medicine, Psychology
  • Behavioral neuroscience
  • 1 April 2004
Estrogen (E2) and/or progesterone (P) in the amygdala may influence anxiety, fear, and pain behaviors. Ovariectomized rats were administered subcutaneous or intra-amygdala vehicle, E2, P, or E2 + P:Expand
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