Pregnanolone emulsion A preliminary pharmacokinetic and pharmacodynamic study of a new intravenous anaesthetic agent

@article{Carl1990PregnanoloneEA,
  title={Pregnanolone emulsion A preliminary pharmacokinetic and pharmacodynamic study of a new intravenous anaesthetic agent},
  author={Peder Carl and S. H{\o}gskilde and J W Nielsen and M. BREDGAARD S{\o}rensen and M. Lindholm and Bo Karl{\'e}n and T. B{\"a}ckstr{\o}},
  journal={Anaesthesia},
  year={1990},
  volume={45}
}
Pregnanolone emulsion, a new steroid anaesthetic agent, was administered intravenously as bolus doses to six young healthy male volunteers in a preliminary pharmacokinetic and pharmacodynamic study. The plasma concentration‐time curves fitted a two‐compartment model. The elimination half‐life was between 0.9 and 1.4 hours, volume of central compartment between 0.95 and 2.10 litres/kg, volume of distribution between 3.75 and 5.58 litres/kg and total body clearance between 1.80 and 3.07 (litres… Expand
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TLDR
The results indicate that the anaesthetic properties of pregnanolone emulsion are very similar to those of Althesin, and further studies will show whether it can fill the major vacuum left in anaesthetic practice after the withdrawal ofAlthesin. Expand
Anaesthetic properties of pregnanolone emulsion
TLDR
The results indicate that pregnanolone emulsion may provide a shortacting, less cumulative and less toxic alternative to existing intravenous anaesthetic agents. Expand
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TLDR
Studies in the rat of pregnanolone, a pharmacologically active metabolite of progesterone, indicated rapid transformation to more polar metabolites, and it was proposed that redistribution rather than hepatic metabolism was the principle mechanism for termination of the hypnotic effect of pregnancy-induced hypnosis. Expand
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The plasma concentrations of alphaxalone were measured with a gas chromatographic technique in patients following a single i.v. injection of Althesin, and in volunteers following oral administration, and a comparison with the pharmacokinetics of lignocaine was made. Expand
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TLDR
Pregnanolone emulsion might be a useful alternative drug in the management of convulsive states resistant to conventional therapy. Expand
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TLDR
Overall sequelae were less with the new steroid than either 5% propanidid or the more concentrated barbiturate solutions, and the incidence of venous complications was studied under comparable conditions. Expand
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TLDR
The qualitative and quantitative distribution of the epimeric steroids may reflect hormonal action not only of progesterone but also of the so called metabolites. Expand
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