Peptide Initiation Factors

Known as: Initiation Factors, Peptide, Translational Initiation Factor, Translation Initiation Factor 
One of several soluble proteins involved in the initiation of protein or RNA synthesis.(On-line Medical Dictionary)
National Institutes of Health

Related topics

Related topics

28 relations
Eukaryotic Initiation Factor-2BEukaryotic Initiation Factor-4FEukaryotic Translation Initiation Factor 5, humanGenetic Translation Process
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Narrower (12)

IDI2 protein, Hordeum vulgareIF2 protein, archaealLepA protein, E coliaIF-5A
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Broader (1)

Peptides

Papers overview

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Review
2010
Review
2010
The mechanism of eukaryotic translation initiation and principles of its regulation
Protein synthesis is principally regulated at the initiation stage (rather than during elongation or termination), allowing rapid… (More)
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Highly Cited
2005
Highly Cited
2005
MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function.
MicroRNAs (miRNAs) repress translation of target mRNAs by interaction with partially mismatched sequences in their 3' UTR. The… (More)
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Highly Cited
2002
Highly Cited
2002
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas.
Phosphorylation of eukaryotic initiation factor 2 alpha (eIF-2 alpha) is typically associated with stress responses and causes a… (More)
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Highly Cited
2000
Highly Cited
2000
Regulated translation initiation controls stress-induced gene expression in mammalian cells.
Protein kinases that phosphorylate the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) are activated in stressed… (More)
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Highly Cited
2000
Highly Cited
2000
EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome
Wolcott-Rallison syndrome (WRS) is a rare, autosomal recessive disorder characterized by permanent neonatal or early infancy… (More)
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Review
1999
Review
1999
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.
Eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that mediates recruitment of ribosomes to mRNA. This… (More)
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Highly Cited
1998
Highly Cited
1998
A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs.
Initiation of translation of hepatitis C virus and classical swine fever virus mRNAs results from internal ribosomal entry. We… (More)
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Highly Cited
1998
Highly Cited
1998
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control.
In response to various environmental stresses, eukaryotic cells down-regulate protein synthesis by phosphorylation of the alpha… (More)
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Highly Cited
1995
Highly Cited
1995
The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins.
Eukaryotic translation initiation factor 4E (eIF-4E), which possesses cap-binding activity, functions in the recruitment of mRNA… (More)
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Review
1991
Review
1991
Structural features in eukaryotic mRNAs that modulate the initiation of translation.
In higher eukaryotes, translation is modulated at the level of initiation by five aspects of mRNA structure: (i) the m7G cap; (ii… (More)
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