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Bacterial endotoxin: molecular relationships of structure to activity and function
The biological analysis of synthetic lipid A partial structures proved that the expression of endotoxic activity depends on a unique primary structure and a peculiar endotoxic conformation, and molecular and submolecular details of the specificity of the interaction of lipid A with responsive host cells are determined. Expand
SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo.
SDZ RAD is a new, orally active rapamycin-derivative that is immunosuppressive in vitro that efficiently prevents graft rejection in rat models of allotransplantation and has been selected for development for use in combination with cyclosporine A to prevent acute and chronic rejection after solid organ allotransplplantation. Expand
Prolonged action of a chimeric interleukin-2 receptor (CD25) monoclonal antibody used in cadaveric renal transplantation.
The chRFT5 was well tolerated with no immediate adverse effects during 6 spaced infusions (from before transplantation to day 24) in 24 patients escalating from 2.5- to 25-mg dosages, and no further cases have been observed to a minimum of 2 years' follow-up. Expand
A broadly cross-protective monoclonal antibody binding to Escherichia coli and Salmonella lipopolysaccharides.
The discovery of WN1 222-5 settles the long-lasting controversy over the existence of anti-core LPS MAbs with both cross-reactive and cross-protective activity, opening new possibilities for the immunotherapy of sepsis caused by gram-negative bacteria. Expand
Initiation of mammalian protein synthesis. I. Purification and characterization of seven initiation factors.
Seven protein factors from rabbit reticulocytes, all of which are presumed to be involved in the initiation of mammalian protein synthesis, are purified to homogeneity with the exception of eIF-4B, which was 60% to 70% pure. Expand
Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors.
A model of the sequential steps in the assembly of the 80 S initiation complex in mammalian protein synthesis is presented and specific roles of the initiation factors, ATP and GTP are demonstrated. Expand
T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level.
Neither antigen nor histocompatibility, but antigen-unspecific factor(s) for growth and Ig secretion are required to stimulate a B-cell blast through the next round of division. Expand
Molecular mechanisms of immunosuppression.
It is found that CsA binding to its intracellular receptor (cyclophilin) is required but not sufficient for immunosuppression, and a significant understanding of the structure-activity relationship of Cs a has emerged. Expand
Initiation of mammalian protein synthesis: the importance of ribosome and initiation factor quality for the efficiency of in vitro systems.
Major uncertainties and ambiguities in the search for and identification of true initiation factors, as opposed to structural ribosome proteins needed for the reconstitution of damaged ribosomes, can be reduced by using this system. Expand
Initiation of eukaryotic protein synthesis: (Met-tRNA f -40S ribosome) initiation complex catalysed by purified initiation factors in the absence of mRNA.
Two mammalian initiation factors are needed to bind initiator Met-tRNAf to the 40S ribosome subunit in the absence of mRNA. One, purified from three different sources, catalyses specifically theExpand