• Publications
  • Influence
How a Circadian Clock Adapts to Seasonal Decreases in Temperature and Day Length
We show that a thermosensitive splicing event in the 3' untranslated region of the mRNA from the period (per) gene plays an important role in how a circadian clock in Drosophila adapts to seasonallyExpand
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Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime
Protein phosphorylation has a key role in modulating the stabilities of circadian clock proteins in a manner specific to the time of day. A conserved feature of animal clocks is that Period (Per)Expand
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A role for CK2 in the Drosophila circadian oscillator
The posttranslational modification of clock proteins is critical for the function of circadian oscillators. By genetic analysis of a Drosophila melanogaster circadian clock mutant known as Andante,Expand
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The Drosophila CLOCK Protein Undergoes Daily Rhythms in Abundance, Phosphorylation, and Interactions with the PER–TIM Complex
We report the in vivo characterization of the Drosophila CLOCK protein (dCLOCK), a transcription factor that is required for the expression of the circadian clock genes period (per) and timelessExpand
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Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein.
  • E. Kim, I. Edery
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 18 April 2006
The first circadian-relevant kinase to be identified was DOUBLE-TIME (DBT) in Drosophila, a homolog of vertebrate CKIepsilon, which regulates the progressive phosphorylation and stability of PERIODExpand
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Resetting the Drosophila Clock by Photic Regulation of PER and a PER-TIM Complex
Circadian clocks can be reset by light stimulation. To investigate the mechanism of this phase shifting, the effects of light pulses on the protein and messenger RNA products of the Drosophila clockExpand
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Temporal phosphorylation of the Drosophila period protein.
The period gene (per) is required for Drosophila melanogaster to manifest circadian (congruent to 24 hr) rhythms. We report here that per protein (PER) undergoes daily oscillations in apparentExpand
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dCLOCK Is Present in Limiting Amounts and Likely Mediates Daily Interactions between the dCLOCK–CYC Transcription Factor and the PER–TIM Complex
In Drosophila melanogaster four circadian clock proteins termed PERIOD (PER), TIMELESS (TIM), dCLOCK (dCLK), and CYCLE (CYC/dBMAL1) function in a transcriptional feedback loop that is a core elementExpand
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PAS is a dimerization domain common to Drosophila Period and several transcription factors
MUTATIONS in the period gene product (PER) can shorten or lengthen the circadian rhythms of Drosophila melanogaster 1, but its biochemical activity has not been established. PER contains a motif ofExpand
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PER and TIM Inhibit the DNA Binding Activity of aDrosophila CLOCK-CYC/dBMAL1 Heterodimer without Disrupting Formation of the Heterodimer: a Basis for Circadian Transcription
ABSTRACT The Drosophila CLOCK (dCLOCK) and CYCLE (CYC) (also referred to as dBMAL1) proteins are members of the basic helix-loop-helix PAS (PER-ARNT-SIM) superfamily of transcription factors and areExpand
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