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A decade of molecular biology of retinoic acid receptors
  • P. Chambon
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1 July 1996
A review of recent developments in structure‐ function relationships of retinoic acid receptors focuses on recent developments, particularly in the area of structure‐function relationships. Expand
The nuclear receptor superfamily: The second decade
This research presents a new probabilistic procedure called ‘spot-spot analysis’ to characterize the response of the immune system to the presence of E.coli. Expand
Two distinct estrogen‐regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.
Using the hPR gene 5′‐flanking sequences as promoter region in chimeric genes, it is shown that a functional promoter directs initiation of hPR mRNAs from the authentic start sites located at +1 and +15. Expand
Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains.
The construction and characterization of a series of chimeric recombinases, each consisting of Cre fused to a mutated human oestrogen receptor (ER) ligand-binding domain (LBD) are reported, which should be useful for efficient spatio-temporally controlled site-directed somatic mutagenesis. Expand
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development
It is established that RA synthesized by the post-implantation mammalian embryo is an essential developmental hormone whose lack leads to early embryo death. Expand
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor
It is shown that the agonist-activated AhR/Arnt heterodimer directly associates with oestrogen receptors ER-α and ER-β, which results in the recruitment of unliganded ER and the co-activator p300 to ostrogen-responsive gene promoters, leading to activation of transcription and oestrogensic effects. Expand
Organization and expression of eucaryotic split genes coding for proteins.
This paper organizes the organization of protein codes into split genes, a small number of which are expressed in the chickenuct, and discusses generalization, generalization and Molecular Evolution. Expand
A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene
The results reveal the existence of a skeletogenic ground pattern program common to at least the mesenchymal NCC that originated from rhombomeres 2 and 4 and the appearance of an atavistic reptilian pterygoquadrate element in Hoxa-2 mutants suggests that this ground pattern is intermediate between reptiles and mammals. Expand
TIF2, a 160 kDa transcriptional mediator for the ligand‐dependent activation function AF‐2 of nuclear receptors.
The cloning of the 160 kDa human nuclear protein TIF2 is reported, which exhibits all properties expected for a mediator of AF‐2 and exhibits partial sequence homology with the recently isolated steroid receptor coactivator SRC‐1, indicating the existence of a novel gene family of nuclear receptor transcriptional mediators. Expand
Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases.
A new ligand-dependent recombinase, Cre-ER(T2), was recently characterized, which was approximately 4-fold more efficiently induced by OHT than Cre- ER(T) in cultured cells, and a dose-response study showed that Cre-Er(T 2) was approximately 10- fold more sensitive to OHT induction thanCre-ER (T). Expand