• Publications
  • Influence
Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon
The double-stranded (ds) RNA-activated protein kinase from human cells is a 68 kd protein (p68 kinase) induced by interferon. On activation by dsRNA in the presence of ATP, the kinase becomesExpand
  • 898
  • 39
Simian Immunodeficiency Virus Replicates to High Levels in Sooty Mangabeys without Inducing Disease
ABSTRACT A serologic survey of primates living in a French zoo allowed identification of three cases of infection with simian immunodeficiency virus in sooty mangabeys (Cercocebus atys) (SIVsm).Expand
  • 287
  • 17
The human 2',5'-oligoadenylate synthetase family: interferon-induced proteins with unique enzymatic properties.
2',5'-Oligoadenylate synthetase (2',5'-OAS) was discovered and characterized as an interferon (IFN)-induced enzyme that in the presence of double-stranded (ds) RNA converts ATP into 2',5'-linkedExpand
  • 221
  • 14
Activation of IFN-beta element by IRF-1 requires a posttranslational event in addition to IRF-1 synthesis.
Expression of the Type I IFN (i.e., IFN-alpha s and IFN-beta) genes is efficiently induced by viruses at the transcriptional level. This induction is mediated by at least two types of positiveExpand
  • 182
  • 13
The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.
The demonstration by Kerr and colleagues that double-stranded (ds) RNA inhibits drastically protein synthesis in cell-free systems prepared from interferon-treated cells, suggested the existence ofExpand
  • 159
  • 13
Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.
The human p68 kinase is an interferon‐regulated enzyme that inhibits protein synthesis when activated by double‐stranded RNA. We show here that when expressed in Saccharomyces cerevisiae, the p68Expand
  • 285
  • 12
PKR Stimulates NF-κB Irrespective of Its Kinase Function by Interacting with the IκB Kinase Complex
ABSTRACT The interferon (IFN)-induced double-stranded RNA-activated protein kinase PKR mediates inhibition of protein synthesis through phosphorylation of the α subunit of eukaryotic initiationExpand
  • 191
  • 10
Surface Expressed Nucleolin Is Constantly Induced in Tumor Cells to Mediate Calcium-Dependent Ligand Internalization
Background Nucleolin is one of the major proteins of the nucleolus, but it is also expressed on the cell surface where is serves as a binding protein for variety of ligands implicated inExpand
  • 141
  • 10
  • PDF
Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells.
Lactoferrin (Lf), a multifunctional molecule present in mammalian secretions and blood, plays important roles in host defense and cancer. Indeed, Lf has been reported to inhibit the proliferation ofExpand
  • 207
  • 9
On the discovery of interferon-inducible, double-stranded RNA activated enzymes: the 2'-5'oligoadenylate synthetases and the protein kinase PKR.
  • A. Hovanessian
  • Biology, Medicine
  • Cytokine & growth factor reviews
  • 1 October 2007
The demonstration that double-stranded (ds) RNA inhibits protein synthesis in cell-free systems prepared from interferon-treated cells, lead to the discovery of the two interferon-induced,Expand
  • 110
  • 9