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Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon
TLDR
The molecular cloning and characterization of several related cDNAs from which can be deduced the full-length p68 kinase sequence are reported, which predicts a protein of 550 amino acids containing all of the conserved domains specific for members of the protein kinase family.
Simian Immunodeficiency Virus Replicates to High Levels in Sooty Mangabeys without Inducing Disease
TLDR
The data indicated that SIVsmFr replicated at a high rate in mangabeys, despite the nonpathogenic character of infection in this host, and the lack of pathogenicity of Sivsm for its natural host cannot be explained by limited viral replication or by tight containment of viral production.
The human 2',5'-oligoadenylate synthetase family: interferon-induced proteins with unique enzymatic properties.
TLDR
Three distinct forms of 2',5'-OAS exist, small, medium, and large, which contain 1, 2, and 3 OAS units, respectively, and are encoded by distinct genes clustered on the 2,5',OAS locus on human chromosome 12.
Activation of IFN-beta element by IRF-1 requires a posttranslational event in addition to IRF-1 synthesis.
TLDR
The results suggest the importance ofIRF-1 synthesis and post-translational modification event(s), possibly phosphorylation for the efficient activation of IRF-Es, which are otherwise under negative regulation by IRf-2.
The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.
TLDR
These findings illustrate the apparent structural and functional complexity of the human 2'-5'OAS family, and suggest that these proteins may have distinct roles in the cell.
Surface Expressed Nucleolin Is Constantly Induced in Tumor Cells to Mediate Calcium-Dependent Ligand Internalization
TLDR
The results demonstrate that the expression of surface nucleolin is an early metabolic event coupled with tumor cell proliferation and stress response, and makes them a preferential target for the inhibitory action of anticancer agents that target surfaceucleolin.
PKR Stimulates NF-κB Irrespective of Its Kinase Function by Interacting with the IκB Kinase Complex
TLDR
A novel pathway by which PKR can modulate the NF-κB signaling pathway without using its kinase activity is revealed, which apparently does not require the integrity of the IKK complex.
Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.
The human p68 kinase is an interferon‐regulated enzyme that inhibits protein synthesis when activated by double‐stranded RNA. We show here that when expressed in Saccharomyces cerevisiae, the p68
On the discovery of interferon-inducible, double-stranded RNA activated enzymes: the 2'-5'oligoadenylate synthetases and the protein kinase PKR.
  • A. Hovanessian
  • Biology, Medicine
    Cytokine & growth factor reviews
  • 1 October 2007
TLDR
These enzymes play key roles in two independent pathways that regulate overall protein synthesis and the mechanism of the antiviral action of interferon, and are now shown to regulate other cellular events, such as gene induction, normal control of cell growth, differentiation and apoptosis.
Four different forms of interferon-induced 2',5'-oligo(A) synthetase identified by immunoblotting in human cells.
TLDR
The 2',5'-oligo(A) synthetase activity induced by interferons in human cells appears, therefore, as a complex multienzyme system.
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