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Mechlorethamine

Known as: N-Methyl-bis(beta-chloroethyl)amine, Nitrogen Mustard, Methylchlorethamine 
A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of… 
National Institutes of Health

Related topics

Related topics

48 relations

Narrower (19)

4-(methylsulfinyl)phenyl nitrogen mustardCaryolysineCloraminEmbichin
Alkylating Activity [MoA]Communicable DiseasesDrug AllergyHodgkin Disease

Broader (9)

Alkylating AgentsAminesAntineoplastic AgentsAntineoplastic Agents, Alkylating

Papers overview

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Highly Cited
2000
Highly Cited
2000
The influence of macrocyclic polyether constitution upon ammonium ion/crown ether recognition processes
Secondary dialkylammonium (R2NH2+) ions are bound readily by dibenzo[24]crown-8 (DB24C8) to form threaded complexes, namely [2… 
Highly Cited
1996
Highly Cited
1996
Toward antibody-directed "abzyme" prodrug therapy, ADAPT: carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing.
Antibody-directed enzyme prodrug therapy, ADEPT, is a recent approach to targeted cancer chemotherapy intended to diminish the… 
Highly Cited
1992
Highly Cited
1992
Intramolecular catalysis of a proline isomerization reaction in the folding of dihydrofolate reductase.
The cis/trans isomerization of the peptide bond preceding proline residues in proteins can limit the rate at which a protein… 
Highly Cited
1989
Highly Cited
1989
Generation of elusive neutrals and dications by neutralization resp. Charge stripping of monocations in beam experiments
Abstract 
Highly Cited
1987
Highly Cited
1987
Chiral control of the Staudinger reaction
Abstract 
Highly Cited
1984
Highly Cited
1984
Proteolysis and structure of skeletal muscle actin.
Under standard conditions, G-actin has been submitted to nine proteases of varying specificity, and in each case the pattern of… 
Highly Cited
1979
Highly Cited
1979
Comparison of the substrate specificity of adenosine 3':5'-monophosphate- and guanosine 3':5'-monophosphate-dependent protein kinases. Kinetic studies using synthetic peptides corresponding to…
The substrate specificities of cyclic GMP-dependent and cyclic AMP-dependent protein kinases have been compared by kinetic… 
Highly Cited
1979
Highly Cited
1979
Characterization of "thyroliberin-deamidating enzyme" as a post-proline-cleaving enzyme. Partial purification and enzyme-chemical analysis of the enzyme from anterior pituitary tissue.
An enzyme which catalyzes the deamidation of thyroliberin (TRF; less than Glu-His-Pro-NH2) has been purified 110-fold from… 
Highly Cited
1974
Highly Cited
1974
In vivo stimulation of prolactin secretion in the rat by thyrotropin releasing factor, related peptides and hypothalamic extracts.
pGlu-His-Pro-NH2 (TRF) is shown to be a potent stimulator of PRL secretion in the estrogen-progesterone-pretreated male (EP) rat… 
Highly Cited
1970
Highly Cited
1970
Porcine thyrotropin releasing hormone is (pyro)glu-his-pro(NH2).
Porcine thyrotropin releasing hormone, isolated from the hypothalamus, and synthetic L-(pyro)Glu-L-His-L-Pro(NH2) are…