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Mechlorethamine

Known as: N-Methyl-bis(beta-chloroethyl)amine, Nitrogen Mustard, Methylchlorethamine 
A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of… 
National Institutes of Health

Related topics

Related topics

48 relations

Narrower (19)

4-(methylsulfinyl)phenyl nitrogen mustardCaryolysineCloraminEmbichin
Alkylating Activity [MoA]Communicable DiseasesDrug AllergyHodgkin Disease

Broader (9)

Alkylating AgentsAminesAntineoplastic AgentsAntineoplastic Agents, Alkylating

Papers overview

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Highly Cited
2000
Highly Cited
2000
The influence of macrocyclic polyether constitution upon ammonium ion/crown ether recognition processes
Secondary dialkylammonium (R2NH2+) ions are bound readily by dibenzo[24]crown-8 (DB24C8) to form threaded complexes, namely [2… 
Highly Cited
1992
Highly Cited
1992
Intramolecular catalysis of a proline isomerization reaction in the folding of dihydrofolate reductase.
The cis/trans isomerization of the peptide bond preceding proline residues in proteins can limit the rate at which a protein… 
Highly Cited
1989
Highly Cited
1989
Generation of elusive neutrals and dications by neutralization resp. Charge stripping of monocations in beam experiments
Abstract 
Highly Cited
1987
Highly Cited
1987
Chiral control of the Staudinger reaction
Abstract 
Highly Cited
1984
Highly Cited
1984
Intragenic regions required for LamB export.
Escherichia coli strains containing a series of lamB-lacZ fusions have been isolated and characterized. Each of these fusions… 
Highly Cited
1979
Highly Cited
1979
Comparison of the substrate specificity of adenosine 3':5'-monophosphate- and guanosine 3':5'-monophosphate-dependent protein kinases. Kinetic studies using synthetic peptides corresponding to…
The substrate specificities of cyclic GMP-dependent and cyclic AMP-dependent protein kinases have been compared by kinetic… 
Highly Cited
1979
Highly Cited
1979
Characterization of "thyroliberin-deamidating enzyme" as a post-proline-cleaving enzyme. Partial purification and enzyme-chemical analysis of the enzyme from anterior pituitary tissue.
An enzyme which catalyzes the deamidation of thyroliberin (TRF; less than Glu-His-Pro-NH2) has been purified 110-fold from… 
Highly Cited
1955
Highly Cited
1955
Studies on the mechanism of action of ionizing radiations. XIII. The effect of x-irradiation on some physico-chemical properties of amino acids and proteins.
An understanding of the mechanism of action of ionizing radiations on living cells requires a knowledge of the changes brought… 
Highly Cited
1951
Highly Cited
1951
Observations on inhibition of nucleic acid synthesis resulting from administration of nitrogen mustard, urethan,. colchicine, 2,6-diaminopurine, 8-azaguanine, potassium arsenite, and cortisone.
Using the technic of measuring the incorporation of formate carbon into nucleic acid purines of control and treated mice, data… 
Highly Cited
1951
Highly Cited
1951
The use of x-ray and nitrogen mustard to determine the mitotic and intermitotic times in normal and malignant rat tissues.
Summary and Conclusions 1.By determining the rate of decline of the mitotic indices of the jejunum, bone marrow, Jensen sarcoma…