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Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
This work characterized another mammalian member of the CRF family and localized its urotensin-like immunoreactivity to, and cloned related complementary DNAs from, a discrete rat midbrain region, and deduced a peptide that is related to u Rotensin and CRF, which is named urocortin, which could be an endogenous ligand for type-2 CRF receptors.
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action.
Findings are reviewed that have documented which cytokines have been shown to influence hormone secretion from the HPA axis, determined under what physiological/pathophysiological circumstances endogenous cytokines regulate HPAaxis activity, established the possible sites of cytokine action on HPA Axis hormone secretion, and identified the potential neuroanatomic and pharmacological mechanisms by which cytokine signal the neuroendocrine hypothalamus.
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin.
Effect of stress on the activity of the hypothalamic-pituitary-gonadal axis: peripheral and central mechanisms.
A variety of hormones or neurotransmitters act within the brain to mediate the inhibitory influence of both acute and prolonged stresses on reproductive function, including CRF, POMC peptides, and biogenic amines.
Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor.
In this report, human IL-1 is shown to activate the adrenocortical axis at the level of the brain, stimulating the release of the controlling hormone corticotropin-releasing factor (CRF) from the hypothalamus.
Corticotropin-Releasing Factor (CRF) and Endocrine Responses to Stress: CRF Receptors, Binding Protein, and Related Peptides
Recent findings with respect to CRF, its receptors, binding protein, and CRF-related peptides are described, which provide further insights into the role and mechanisms of CRF action in stress responses.
Corticosteroid-Dependent Plasticity Mediates Compulsive Alcohol Drinking in Rats
- L. Vendruscolo, E. Barbier, +9 authors G. Koob
- Psychology, MedicineThe Journal of Neuroscience
- 30 May 2012
The GR system appears to be involved in the development of alcohol dependence and may represent a potential pharmacological target for the treatment of alcoholism.
Corticotropin-releasing factor: actions on the sympathetic nervous system and metabolism.
- M. Brown, L. Fisher, J. Spiess, C. Rivier, J. Rivier, W. Vale
- Chemistry, MedicineEndocrinology
- 1 September 1982
It is demonstrated that CRF acts within the brain to stimulate sympathetic outflow, which results in the development of hyperglycemia, which is secondary to the enhanced secretion of both epinephrine and norepinephrine.
Chemical and biological characterization of corticotropin releasing factor.
The chapter concludes with the evidence that supports CRF or a closely related peptide in the neuroregulation of the pituitary corticotropic cells.