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Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
This work characterized another mammalian member of the CRF family and localized its urotensin-like immunoreactivity to, and cloned related complementary DNAs from, a discrete rat midbrain region, and deduced a peptide that is related to u Rotensin and CRF, which is named urocortin, which could be an endogenous ligand for type-2 CRF receptors. Expand
The melanin‐concentrating hormone system of the rat brain: An immuno‐ and hybridization histochemical characterization
The results suggest that ppMCH‐derived peptides may serve as neurotransmitters or modulators of prominence in a surprisingly expansive projection field of incerto‐hypothalamic neurons. Expand
CRF and CRF receptors: role in stress responsivity and other behaviors.
  • T. Bale, W. Vale
  • Biology, Medicine
  • Annual review of pharmacology and toxicology
  • 16 January 2004
Although CRF appears to play a stimulatory role in stress responsivity through activation of CRFR1, specific actions of UcnII and UcnIII on CRFR2 may be important for dampening stress sensitivity. Expand
Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor
  • K. Lewis, C. Li, +11 authors W. Vale
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 19 June 2001
Urocortin III is selective for type 2 CRF receptors and thus represents another potential endogenous ligand for these receptors. Expand
Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors
Cl cloning and initial characterization of a previously unidentified CRF-related neuropeptide, urocortin II (Ucn II), are described, which is expressed centrally and binds selectively toCRF-R2, and identified as a new member of the CRF family of neuropePTides. Expand
Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study.
The results suggest that the PVH plays a critical role in the modulation of ACTH and beta-endorphin release from the pituitary, and that CRF-containing pathways in the brain are involved in the mediation of autonomic responses. Expand
Expression cloning of a human corticotropin-releasing-factor receptor.
The cloning of a cDNA coding for a CRF receptor from a human corticotropic tumor library is reported, which encodes a 415-amino acid protein comprising seven putative membrane-spanning domains and is structurally related to the calcitonin/vasoactive intestinal peptide/growth hormone-releasing hormone subfamily of G protein-coupled receptors. Expand
The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress
The role of the HPA axis in the integration of adaptive responses to stress is discussed and the major neuronal and endocrine systems that contribute to the regulation of theHPA axis and the maintenance of homeostasis in the face of aversive stimuli are identified. Expand
Structural basis of BMP signalling inhibition by the cystine knot protein Noggin
The crystal structure of the antagonist Noggin bound to BMP-7 is reported, which shows that Nogsgin inhibits BMP signalling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Expand