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Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence.
Summary The complete amino acid sequence of porcine LH- and FSH- releasing hormone has been provisionally determined by the use on a micro-scale of the combined Edman-dansyl procedure coupled with
Immunocytochemical localization of corticotropin-releasing factor (CRF) in the rat brain.
The widespread but selective distribution of neurons containing CRF-like immunoreactivity supports the neuroendocrine role of this peptide and suggests that CRF, similarly to other neuropeptides, may also function as a neuromodulator throughout the brain.
Somatostatin analogues inhibit growth of pancreatic cancer by stimulating tyrosine phosphatase.
Observations indicate that somatostatin and some of its analogues can act as growth inhibitors in cancer cells through the activation of tyrosine phosphatase.
Hypothalamic Hormones and Cancer
Treatment of many cancers remains a major challenge, but new therapeutic modalities are being developed based on antagonists of GH-RH and bombesin, which inhibit growth factors or their receptors, and somatostatin, which can be targeted to receptors for these peptides in various cancers and their metastases.
Androgens Regulate Prostate Cancer Cell Growth via an AMPK-PGC-1α-Mediated Metabolic Switch
It is demonstrated that androgens can co-opt the AMPK-PGC-1α signaling cascade, a known homeostatic mechanism, to increase prostate cancer cell growth.
Isolation and properties of the FSH and LH-releasing hormone.
The LH-RH preparation isolated has FSH-releasing hormone (FSH-RH) activity, which appears to be intrinsic to LH- RH, and appears to represent the hypothalamic hormone which controls the secretion of both LH and FSH from the pituitary.
Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediation by human somatostatin receptor subtypes SSTR1 and SSTR2.
The effects of somatostatin analogues RC-160 and SMS-201-995 on tyrosine phosphatase and cell proliferation were investigated and mRNAs of receptor subtypes were variably expressed in different pancreatic and colon cancer cell lines, indicating the necessity of a precise analysis of receptors subtypes in target tissues before therapy with analogues.
Cancer chemotherapy based on targeting of cytotoxic peptide conjugates to their receptors on tumors.
New cytotoxic analogs of LHRH, AN-207 which consists of 2-pyrrolino-DOX (AN-201) coupled to the same carrier, show high-affinity binding and are much less toxic and more effective in vivo than their respective radicals in inhibiting tumor growth in L HRH receptor-positive models of human ovarian, mammary, or prostatic cancer.
Gonadotropin-Releasing Hormone: One Polypeptide Regulates Secretion of Luteinizing and Follicle-Stimulating Hormones
It appears that this peptide represents the hypothalamic hormone regulating the secretion of both luteinizing hormone and follicle-stimulating hormone from the pituitaries of several species.
Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity.
Evidence is provided of the role of circulating IGF-I as an important component of overall insulin action in peripheral tissues and of the insulin insensitivity seen in the LID mice is muscle specific.