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Fluphenazine

Known as: 2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine, Fluphenazine [Chemical/Ingredient], 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-(9CI) 
A phenothiazine with antipsychotic activity. Fluphenazine exerts its actions by blocking postsynaptic dopamine D2 receptors in the limbic, cortical… 
National Institutes of Health

Related topics

Related topics

30 relations

Narrower (10)

7-hydroxyfluphenazine7-hydroxyfluphenazine glucuronideFluphenazine HydrochlorideFluphenazine Hydrochloride 5 MG Oral Tablet

Broader (4)

AntiemeticsAntipsychotic AgentsDopamine Antagonistsphenothiazine
Blood Coagulation DisordersBrain Damage, ChronicComatoseDrug Allergy

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1990
1990
Surreptitious noncompliance with oral fluphenazine in a voluntary inpatient population.
To the Editor.— It is well-known that schizophrenic inpatients do not always swallow their neuroleptic tablets. Default rates in… 
1985
1985
II. the Incidence of Compliance Problems, Side-effects, Neurotic Symptoms and Depression
Summary Seven years after the completion of the original trial, over 73% of patients were maintained on depot neuroleptics, and… 
1984
1984
Fluphenazine plasma levels and clinical response.
Plasma levels of fluphenazine and clinical response were examined in 19 inpatient schizophrenics (DSM-III diagnoses) using a… 
1982
1982
Fluphenazine blood levels and clinical response.
The radioreceptor assay for neuroleptics (NRRA) holds out great theoretical promise as a method for monitoring blood neuroleptic… 
Highly Cited
1981
Highly Cited
1981
Calcium requirement for the secretion of peroxidases by plant cell suspensions.
Spinach (Spinacia oleracea, L.) cells in liquid culture release peroxidases. This release is reduced by EGTA and promoted by… 
Highly Cited
1979
Highly Cited
1979
Dopaminergic control of oxytocin release in lactating rats.
During suckling, anaesthetized lactating rats release regular (about every 7 min) but brief pulses of oxytocin (0.5--1.0 mu… 
1978
1978
Further identification of multiple responses mediated by dopamine in the CNS of Planorbis corneus.
Intracellular recordings from neurones, receiving monosynaptic contacts from a dopamine-containing (DA-containing) neurone in the… 
1978
1978
Sensitive gas-chromatographic determination of fluphenazine in human plasma.
We describe a method for quantitative determination of fluphenazine in human plasma, based on gas chromatography of its… 
1974
1974
Tissue metabolites of trifluoperazine, fluphenazine, prochlorperazine, and perphenazine in the rat: indentification and synthesis.
Rats were treated chronically with increasing doses of trifluoperazine, prochlorperazine, fluphenazine, or perphenazine per os… 
1960
1960
Preliminary results with fluphenazine (prolixin) in chronic psychotic patients.
Fluphenazine is a highly potent psychopharmacologic agent which is effective in controlling behavioral symptoms in chronic…