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Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey.
TLDR
The prevalence of psychiatric disorders is greater than previously thought to be the case, and morbidity is more highly concentrated than previously recognized in roughly one sixth of the population who have a history of three or more comorbid disorders.
Biological Insights From 108 Schizophrenia-Associated Genetic Loci
TLDR
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Genetic epidemiology of major depression: review and meta-analysis.
TLDR
A meta-analysis of relevant data from primary studies of the genetic epidemiology of major depression suggested that familial aggregation was due to additive genetic effects, with a minimal contribution of environmental effects common to siblings and substantial individual-specific environmental effects/measurement error.
Childhood adversity and adult psychiatric disorder in the US National Comorbidity Survey.
TLDR
The existence of strong clustering among childhood adversities and lifetime co-morbidity among adult disorders means that caution is needed in interpreting the results of previous single-adversity single-disorder studies as documenting unique effects of specific Childhood adversities on specific adult disorders.
Causal relationship between stressful life events and the onset of major depression.
TLDR
Stressed life events have a substantial causal relationship with the onset of episodes of major depression, however, about one-third of the association between stressful life events and onsets of depression is noncausal, since individuals predisposed to major depression select themselves into high-risk environments.
Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia
TLDR
It is estimated that 8,300 independent, mostly common SNPs contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability.
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
TLDR
A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent and significant loci and finds important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia.
The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women.
TLDR
The underlying structure of the genetic and environmental risk factors for the common psychiatric and drug abuse disorders in men and women is very similar.
Common variants on chromosome 6p22.1 are associated with schizophrenia
TLDR
It is demonstrated that common schizophrenia susceptibility alleles can be detected and the characterization of these signals will suggest important directions for research on susceptibility mechanisms.
A review and meta-analysis of the genetic epidemiology of anxiety disorders.
TLDR
Meta-analyses of data from family and twin studies of panic disorder, generalized anxiety disorder, phobias, and obsessive-compulsive disorder revealed significant familial aggregation, underscoring the importance of identifying putative environmental risk factors that predispose individuals to anxiety.
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