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Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity.
Fura-2-based Ca imaging showed that numerous chemokines, including SDF-1alpha, RANTES, and fractalkine, affect neuronal Ca signaling, suggesting that hippocampal neurons possess a wide variety of chemokine receptors.
Chemokines and Glycoprotein120 Produce Pain Hypersensitivity by Directly Exciting Primary Nociceptive Neurons
Evidence is provided that chemokines and gp120 may produce painful effects via direct actions on chemokine receptors expressed by nociceptive neurons in rats associated with HIV-1 infection and inflammation.
Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival.
Fractalkine protects hippocampal neurons from the neurotoxicity induced by the HIV-1 envelope protein gp120(IIIB), an effect blocked by anti-CX(3)CR1 antibodies, and experiments demonstrate that Akt activation is responsible for the neuroprotective effects of fractalkine.
Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro.
The relationship between the integrated ICa and the peak of the [Ca2+]i transient reached an asymptote at large Ca2+ loads indicating that Ca2(+)‐dependent processes became more efficient or that low‐affinity processes had been recruited.
Characterization of pyrethroid resistance and susceptibility to coumaphos in Mexican Boophilus microplus (Acari: Ixodidae).
Two patterns of pyrethroid resistance were characterized from Boophilus microplus (Canestrini) collected in Mexico. One was characteristic of a kdr mutation and the other involved esterase and
Structure and functional characterization of neuronal alpha 1E calcium channel subtypes.
We have cloned overlapping cDNAs encoding alpha 1E Ca2+ channel subunits from mouse and human brain. We observed that these alpha 1E transcripts were widely distributed in the central nervous system.
Calcium buffering properties of calbindin D28k and parvalbumin in rat sensory neurones.
These data demonstrate that both calbindin D28k and parvalbumin effectively buffer Ca2+ in a cellular environment and may therefore regulate Ca(2+)‐dependent aspects of neuronal function.
α1E-Containing Ca2+ channels are involved in synaptic plasticity
It is demonstrated here that α1E-containing voltage-dependent calcium channels (VDCCs) shift the threshold for mossy fiber LTP, suggesting a previously undescribed role for α1 E-containing VDCCs is suggested by these results.
Selective opioid agonists modulate afferent transmission in the rat nucleus tractus solitarius.
We examined the effects of agonists at mu, delta and kappa opioid receptors on neurons located in the nucleus tractus solitarius of the rat using whole-cell patch-clamp recordings in brainstem