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Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗ ∗ See accompanying Editorial, in this issue.
BACKGROUND This report provides histopathological evidence to support prior neuroimaging findings of decreased volume and altered metabolism in the frontal cortex in major depressive disorder. Expand
Prevalence of the metabolic syndrome in patients with schizophrenia: Baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison
The metabolic syndrome is highly prevalent in US schizophrenia patients and represents an enormous source of cardiovascular risk, especially for women, so clinical attention must be given to monitoring for this syndrome, and minimizing metabolic risks associated with antipsychotic treatment. Expand
Serotonin receptors : their key role in drugs to treat schizophrenia
5-HT has joined DA as a critical target for developing effective APDs and led to the search for novel drugs with complex pharmacology, ending the exclusive search for single-receptor targets. Expand
The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia.
Atypical antipsychotic drugs as a group appear to be superior to typical neuroleptics with regard to cognitive function, however, available data suggest that these drugs produce significant differences in specific cognitive functions. Expand
Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.
The pKi values of 13 reference typical and 7 reference atypical antipsychotic drugs (APDs) for rat striatal dopamine D-1 and D-2 receptor binding sites and cortical serotonin (5-HT2) receptor bindingExpand
Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment.
For patients with schizophrenia who prospectively failed to improve with an atypical antipsychotic, clozapine was more effective than switching to another newer atypicals antipsychotics. Expand
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.
The authors examined the affinities of 36 typical and atypical antipsychotic agents for the cloned rat 5-hydroxytryptamine-6 and rat5-HT7 receptors in transiently expressed COS-7 cells or stably transfected HEK-293 cells to identify those with high affinity for the newly discovered 5-HT6 receptor. Expand
The Role of Serotonin in Antipsychotic Drug Action
  • H. Meltzer
  • Psychology, Medicine
  • Neuropsychopharmacology
  • 1 August 1999
Future antipsychotic drug development can include targeting multiple serotonin receptor subtypes, some, or all of which, may contribute to their differences in efficacy and side effect profile. Expand
5‐HT2A and D2 receptor blockade increases cortical DA release via 5‐HT1A receptor activation: a possible mechanism of atypical antipsychotic‐induced cortical dopamine release
The results suggest that the atypical APDs via 5‐HT2A and D2 receptor blockade, regardless of intrinsic 5-HT1A affinity, may promote the ability of 5- HT1A receptor stimulation to increase mPFC DA release, and provide additional evidence that coadministration of 5‐ HT2A antagonists and typical APDs, which are D2 antagonists, may facilitate 5‐ht1A agonist activity. Expand
Lowered ω3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients
There is an abnormal metabolism of omega3 PUFAs in depression and the FA alterations in depression are related to the inflammatory response in that illness; and the disorders may persist despite successful antidepressant treatment. Expand