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Particle length-dependent titanium dioxide nanomaterials toxicity and bioactivity
TLDR
This study demonstrates that alteration of anatase TiO2 nanomaterial into a fibre structure of greater than 15 μm creates a highly toxic particle and initiates an inflammatory response by alveolar macrophages, and suggests that any modification of a nanomMaterial, resulting in a wire, fibre, belt or tube, be tested for pathogenic potential. Expand
Silica binding and toxicity in alveolar macrophages.
TLDR
Current research ideas on silica toxicity and binding in the alveolar macrophage are reviewed and discussed. Expand
Silica-induced apoptosis mediated via scavenger receptor in human alveolar macrophages.
TLDR
It is suggested that fibrogenic particulates, such as silica, caused apoptosis of alveolar macrophages and that this apoptotic potential of fibrogenics particulates may be a critical factor in initiating an inflammatory response resulting in fibrosis. Expand
A comparison of dispersing media for various engineered carbon nanoparticles
TLDR
It is demonstrated that CNP agglomerates are present in all dispersing vehicles to some degree, and the vehicle that contains some protein, lipid or protein/lipid component disperses the CNP best, producing fewer large CNP Agglomerate, and in contrast, vehicles absent of lipid and protein produce the largest CNPagglomerating. Expand
Interlaboratory Evaluation of in Vitro Cytotoxicity and Inflammatory Responses to Engineered Nanomaterials: The NIEHS Nano GO Consortium
TLDR
The results provide justification for the inclusion of mechanism-linked bioactivity assays along with traditional cytotoxicity assays for in vitro screening and suggest that conducting studies with multiple relevant cell types to avoid false-negative outcomes is critical for accurate evaluation of ENM bioactivity. Expand
Effect of MWCNT size, carboxylation, and purification on in vitro and in vivo toxicity, inflammation and lung pathology
TLDR
In vitro and in vivo bioactivity of MWCNT increased with diameter and length, and functionalization by carboxylation completely eliminated the bioactive potential of the M WCNT regardless of size in in vitro testing. Expand
Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice.
TLDR
Data support the idea that ADMA may play a role in airway diseases, including asthma and pulmonary fibrosis, through NOS inhibition and enhancement of arginase activity. Expand
Potential involvement of 4-hydroxynonenal in the response of human lung cells to ozone.
TLDR
In vitro results and demonstration of HNE protein adducts after ozone exposure are consistent with a potential role for HNE in the cellular toxic effects of ozone. Expand
Three human cell types respond to multi-walled carbon nanotubes and titanium dioxide nanobelts with cell-specific transcriptomic and proteomic expression patterns
TLDR
Global transcriptome and proteome analyses were conducted on three human cell types, exposed to two high aspect ratio NP types, to identify patterns of expression that might indicate high versus low NP toxicity. Expand
Asymmetric dimethylarginine induces oxidative and nitrosative stress in murine lung epithelial cells.
TLDR
Elevated ADMA may contribute to the production of ROS and RNS in airway inflammation in asthma by altering the generation of NO and superoxide anion (O2-), leading to peroxynitrite (ONOO-) formation in a mouse epithelial cell line. Expand
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