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Differential signal transduction by five splice variants of the PACAP receptor
A new expression cloning strategy, based on the induction of a reporter gene by cyclic AMP, is used to isolate a complementary DNA encoding the type-I PACAP receptor, suggesting a novel mechanism for fine tuning of signal transduction.
Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens
- D. Robbe, M. Kopf, A. Rémaury, J. Bockaert, O. Manzoni
- Biology, MedicineProceedings of the National Academy of Sciences…
- 11 June 2002
It is shown that stimulation of prelimbic cortex afferents at naturally occurring frequencies causes a long-term depression of nucleus accumbens glutamatergic synapses mediated by eCB release and presynaptic CB1 receptors.
Molecular tinkering of G protein‐coupled receptors: an evolutionary success
Indirect studies have led to a useful model of a common ‘central core’, composed of seven transmembrane helical domains, and its structural modifications during activation of G protein‐coupled receptors.
NMDA-dependent superoxide production and neurotoxicity
It is reported that O·- 2 is produced upon NMDA receptor stimulation in cultured cerebellar granule cells and the nitrone DMPO (5,5-dimethyl pyrroline 1-oxide), used as a spin trap, is more efficient than the nitric oxide synthase inhibitor, L-N G -nitroarginine, in reducing NMDA-induced neuronal death in these cultures.
Metabotropic glutamate receptors: From the workbench to the bedside
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy.
It is suggested that the persistent leakage of serum IgG in the interstitial space and their uptake by neurons may participate in hypoperfusion and in neuronal dysfunction occurring in TLE.
The evidence strongly suggests that these cytokines perform neural functions in normal brain, and it is proposed that they should be thought of as neuromodulators in addition to inflammatory mediators.
Localization and Mechanisms of Action of Cannabinoid Receptors at the Glutamatergic Synapses of the Mouse Nucleus Accumbens
- D. Robbe, G. Alonso, F. Duchamp, J. Bockaert, O. Manzoni
- Biology, MedicineThe Journal of Neuroscience
- 1 January 2001
Electrophysiological techniques and immunohistochemistry suggest that CB1 receptors are located on the cortical afferents to the nucleus and can reduce glutamate synaptic transmission within the NAc by modulating K+ channels activity.
Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP-38) Protects Cerebellar Granule Neurons from Apoptosis by Activating the Mitogen-Activated Protein Kinase (MAP Kinase) Pathway
- Martín Federico Villalba, J. Bockaert, L. Journot
- Chemistry, MedicineThe Journal of Neuroscience
- 1 January 1997
It is demonstrated that PACAP-38 increased survival of cerebellar neurons in a dose-dependent manner by decreasing the extent of apoptosis estimated by DNA fragmentation, and PD98059, an inhibitor of MEK (MAP kinase kinase), completely abolished the antiapoptotic effect of PACAP -38, suggesting that MAP kinase pathway activation is necessary for PACAP.
Functional coupling between ryanodine receptors and L-type calcium channels in neurons
A tight functional coupling between ryanodine receptors and L-type Ca2+ channel in neurons is demonstrated and is demonstrated to be a novel mechanism for Ca2-channel modulation in neurons.