Flavopiridol

Known as: (-)cis-5,7-dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one, Alvocidib freebase, Alvocidib 
The free base form of a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1967-2018
020406019672018

Papers overview

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Highly Cited
2009
Highly Cited
2009
PURPOSE Patients with chronic lymphocytic leukemia (CLL) with high-risk genomic features achieve poor outcomes with traditional… (More)
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Highly Cited
2007
Highly Cited
2007
Despite promising preclinical studies with the cyclin-dependent kinase inhibitor flavopiridol in chronic lymphocytic leukemia… (More)
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Highly Cited
2005
Highly Cited
2005
Flavopiridol is active against chronic lymphocytic leukemia (CLL) cells in vitro and in the treatment of advanced stage disease… (More)
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Highly Cited
2001
Highly Cited
2001
Flavopiridol (L86-8275, HMR1275) is a cyclin-dependent kinase (Cdk) inhibitor in clinical trials as a cancer therapy that has… (More)
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Highly Cited
2001
Highly Cited
2001
Flavopiridol, a flavonoid currently in cancer clinical trials, inhibits cyclin-dependent kinases (CDKs) by competitively blocking… (More)
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Highly Cited
2001
Highly Cited
2001
We sought to characterize the interactions of flavopiridol with members of the ATP-binding cassette (ABC) transporter family… (More)
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Highly Cited
2000
Highly Cited
2000
Flavopiridol (L86-8275, HMR1275) is a cyclin-dependent kinase (Cdk) inhibitor that is in clinical trials as a cancer treatment… (More)
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Highly Cited
2000
Highly Cited
2000
Compounds that inhibit protein kinases are currently undergoing clinical evaluation for the treatment of a variety of… (More)
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Highly Cited
1998
Highly Cited
1998
Flavopiridol has been reported to induce apoptosis in lymphoid cell lines via downregulation of bcl-2. The in vitro activity of… (More)
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Highly Cited
1998
Highly Cited
1998
Flavopiridol is a novel semisynthetic flavone derivative of the alkaloid rohitukine. Flavopiridol is known to inhibit potently… (More)
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