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Flavopiridol

Known as: (-)cis-5,7-dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one, Alvocidib freebase, Alvocidib 
The free base form of a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces… 
National Institutes of Health

Related topics

Related topics

19 relations
Alvocidib HydrochlorideCyclin-Dependent KinasesGene Expression RegulationNegative Regulation of G1 Phase

Broader (7)

Antineoplastic AgentsEnzyme InhibitorsFlavonesFlavonoids

Narrower (1)

L 868275

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine.
Highly Cited
2007
Highly Cited
2007
Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions
The mechanism and functional significance of XIAP and Mcl-1 down-regulation in human leukemia cells exposed to the histone… 
2006
2006
Improvement of esophageal adenocarcinoma cell and xenograft responses to radiation by targeting cyclin-dependent kinases.
Highly Cited
2003
Highly Cited
2003
Flavonoid effects on normal and leukemic cells.
2003
2003
Involvement of the transcription factor E2F1/Rb in kainic acid-induced death of murine cerebellar granule cells.
Review
2002
Review
2002
Flavopiridol, a Novel Cyclin-Dependent Kinase Inhibitor, in Clinical Development
OBJECTIVE: To review preclinical and clinical information on flavopiridol, an inhibitor of cyclin-dependent kinases (CDKs… 
Highly Cited
2002
Highly Cited
2002
Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells.
PURPOSE The goal of this study was to characterize interactions between the Bcr/Abl kinase inhibitor STI571 and the cyclin… 
Highly Cited
2002
Highly Cited
2002
Seventy-Two Hour Continuous Infusion Flavopiridol in Relapsed and Refractory Mantle Cell Lymphoma
The cell cycle regulatory protein cyclin D1, which is over-expressed in 95-100% of mantle cell lymphomas (MCL), is a potential… 
2001
2001
Possible mechanisms of diarrheal side effects associated with the use of a novel chemotherapeutic agent, flavopiridol.
The novel cyclin-dependent kinase inhibitor flavopiridol has recently completed Phase I trials for the treatment of refractory… 
1998
1998
SAC-CI Study on the Excited and Ionized States of Free-Base Porphin: Rydberg Excited States and Effect of Polarization and Rydberg Functions
The ground, excited, and ionized states of free-base porphin (FBP) are reinvestigated by the SAC (symmetry-adapted cluster)/SAC… 
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