Negative Regulation of G1 Phase

Known as: G1 Arrest, G1 Block 
G1 Arrest consists of cellular biochemical mechanisms, responsive to diverse governing conditions (DNA damage, contact inhibition, growth factors… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
The kinase pathway comprising RAS, RAF, mitogen-activated protein kinase kinase (MEK) and extracellular signal regulated kinase… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Mechanisms linking mitogenic and growth inhibitory cytokine signaling and the cell cycle have not been fully elucidated in either… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2000
Highly Cited
2000
DNA damage causes stabilization of p53, leading to G1 arrest through induction of p21cip1. As this process requires transcription… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2000
Highly Cited
2000
The ansamycin antibiotics, herbimycin A (HA) and geldanamycin (GM), bind to a conserved pocket in heat shock protein 90 (Hsp90… (More)
  • figure 1
  • figure 3
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Flavopiridol (L86-8275), a N-methylpiperidinyl, chlorophenyl flavone, can inhibit cell cycle progression in either G1 or G2 and… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
The tumor suppressor p53 contributes to maintaining genome stability by inducing a cell cycle arrest or apoptosis in response to… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
The mdm-2 gene encodes a 90-kDa polypeptide that binds specifically to the p53 tumor suppressor protein. This physical… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
DNA-damaging agents induce a p53-dependent G1 arrest that may be critical for p53-mediated tumor suppression. It has been… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
The present study assessed the role of the p53 tumor suppressor gene in cell cycle arrest and apoptosis following treatment of… (More)
Is this relevant?
Highly Cited
1990
Highly Cited
1990
alpha factor is a negative growth factor and differentiation factor that induces G1 arrest and increases transcription of mating… (More)
Is this relevant?