Skip to search formSkip to main contentSkip to account menu

Negative Regulation of G1 Phase

Known as: G1 Arrest, G1 Block 
G1 Arrest consists of cellular biochemical mechanisms, responsive to diverse governing conditions (DNA damage, contact inhibition, growth factors… 
National Institutes of Health

Related topics

Related topics

24 relations
Alvocidib HydrochlorideCDK inhibitor R547CDKN1A geneCDKN1A wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Downregulation of microRNA-21 expression inhibits proliferation, and induces G1 arrest and apoptosis via the PTEN/AKT pathway in SKM-1 cells
Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis and may progress to acute myeloid leukemia (AML… 
Highly Cited
2013
Highly Cited
2013
MiR-590-5P Inhibits Growth of HepG2 Cells via Decrease of S100A10 Expression and Inhibition of the Wnt Pathway
Hepatocellular carcinoma is one of the most common and lethal cancers worldwide, especially in developing countries. In the… 
2012
2012
Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition.
2011
2011
Aberrant ribosome biogenesis activates c-Myc and ASK1 pathways resulting in p53-dependent G1 arrest
The largest energy consumer in the cell is the ribosome biogenesis whose aberrancy elicits various diseases in humans. It has… 
Highly Cited
2009
Highly Cited
2009
WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells
Epigenetic silencing of secreted wingless-type (Wnt) antagonists through hypermethylation is associated with tobacco smoking and… 
Highly Cited
2006
Highly Cited
2006
E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts
Deregulation of the Rb/E2F pathway in human fibroblasts results in an E2F1-mediated apoptosis dependent on Atm, Nbs1, Chk2 and… 
Highly Cited
2000
Highly Cited
2000
Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest.
The ansamycin antibiotics, herbimycin A (HA) and geldanamycin (GM), bind to a conserved pocket in heat shock protein 90 (Hsp90… 
2000
2000
Expression of p53 and p21 is useful for the prediction of preoperative chemotherapeutic effects in esophageal carcinoma.
The p53 and p21 genes are associated with G1 arrest during the cell cycle and with apoptosis, both of which have a close… 
2000
2000
TP 53 Mutation and p 53 Overexpression for Prediction of Response to Neoadjuvant Treatment in Breast Cancer Patients 1
The value of p53 to predict the cytotoxic effect of two commonly used chemotherapy regimens was assessed in patients with… 
1994
1994
The kinase inhibitor staurosporine induces G1 arrest at two points: effect on retinoblastoma protein phosphorylation and cyclin-dependent kinase 2 in normal and transformed cells.
Staurosporine (ST), a protein kinase inhibitor, at a concentration of 20 nM arrests normal diploid fibroblasts 3 h into G1 (H. A… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)