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Negative Regulation of G1 Phase
Known as:
G1 Arrest
, G1 Block
G1 Arrest consists of cellular biochemical mechanisms, responsive to diverse governing conditions (DNA damage, contact inhibition, growth factors…
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National Institutes of Health
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Related topics
Related topics
24 relations
Alvocidib Hydrochloride
CDK inhibitor R547
CDKN1A gene
CDKN1A wt Allele
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Downregulation of microRNA-21 expression inhibits proliferation, and induces G1 arrest and apoptosis via the PTEN/AKT pathway in SKM-1 cells
Guang Li
,
Yan-ping Song
,
+6 authors
Jin-qian Dai
Molecular Medicine Reports
2018
Corpus ID: 51671224
Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis and may progress to acute myeloid leukemia (AML…
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Highly Cited
2013
Highly Cited
2013
MiR-590-5P Inhibits Growth of HepG2 Cells via Decrease of S100A10 Expression and Inhibition of the Wnt Pathway
Xiangxiang Shan
,
Y. Miao
,
+6 authors
F. Zhou
International Journal of Molecular Sciences
2013
Corpus ID: 1982253
Hepatocellular carcinoma is one of the most common and lethal cancers worldwide, especially in developing countries. In the…
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2012
2012
Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition.
S. Kimbung
,
E. Biskup
,
+8 authors
I. Hedenfalk
Cancer Letters
2012
Corpus ID: 206422499
2011
2011
Aberrant ribosome biogenesis activates c-Myc and ASK1 pathways resulting in p53-dependent G1 arrest
H. Kim
,
Ts. Kim
,
J. Kim
Oncogene
2011
Corpus ID: 30488329
The largest energy consumer in the cell is the ribosome biogenesis whose aberrancy elicits various diseases in humans. It has…
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Highly Cited
2009
Highly Cited
2009
WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells
Yaxiong Tang
,
A. Simoneau
,
+10 authors
X. Zi
Molecular Cancer Therapeutics
2009
Corpus ID: 29187977
Epigenetic silencing of secreted wingless-type (Wnt) antagonists through hypermethylation is associated with tobacco smoking and…
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Highly Cited
2006
Highly Cited
2006
E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts
FM Frame
,
Harry A. Rogoff
,
MT Pickering
,
W. Cress
,
TF Kowalik
Oncogene
2006
Corpus ID: 37038657
Deregulation of the Rb/E2F pathway in human fibroblasts results in an E2F1-mediated apoptosis dependent on Atm, Nbs1, Chk2 and…
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Highly Cited
2000
Highly Cited
2000
Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest.
Mary Srethapakdi
,
Franklin Liu
,
Ranjana Tavorath
,
Neal Rosen
Cancer Research
2000
Corpus ID: 17615329
The ansamycin antibiotics, herbimycin A (HA) and geldanamycin (GM), bind to a conserved pocket in heat shock protein 90 (Hsp90…
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2000
2000
Expression of p53 and p21 is useful for the prediction of preoperative chemotherapeutic effects in esophageal carcinoma.
S. Nakashima
,
S. Natsugoe
,
+9 authors
T. Aikou
Anticancer Research
2000
Corpus ID: 24251978
The p53 and p21 genes are associated with G1 arrest during the cell cycle and with apoptosis, both of which have a close…
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2000
2000
TP 53 Mutation and p 53 Overexpression for Prediction of Response to Neoadjuvant Treatment in Breast Cancer Patients 1
D. Kandioler-eckersberger
,
C. Ludwig
,
+8 authors
R. Jakesz
2000
Corpus ID: 6117479
The value of p53 to predict the cytotoxic effect of two commonly used chemotherapy regimens was assessed in patients with…
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1994
1994
The kinase inhibitor staurosporine induces G1 arrest at two points: effect on retinoblastoma protein phosphorylation and cyclin-dependent kinase 2 in normal and transformed cells.
J. Schnier
,
D. Gadbois
,
K. Nishi
,
E. Bradbury
Cancer Research
1994
Corpus ID: 10910226
Staurosporine (ST), a protein kinase inhibitor, at a concentration of 20 nM arrests normal diploid fibroblasts 3 h into G1 (H. A…
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