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Negative Regulation of G1 Phase

Known as: G1 Arrest, G1 Block 
G1 Arrest consists of cellular biochemical mechanisms, responsive to diverse governing conditions (DNA damage, contact inhibition, growth factors… Expand
National Institutes of Health

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Highly Cited
2006
Highly Cited
2006
The kinase pathway comprising RAS, RAF, mitogen-activated protein kinase kinase (MEK) and extracellular signal regulated kinase… Expand
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Highly Cited
2002
Highly Cited
2002
Mechanisms linking mitogenic and growth inhibitory cytokine signaling and the cell cycle have not been fully elucidated in either… Expand
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Highly Cited
2000
Highly Cited
2000
The value of p53 to predict the cytotoxic effect of two commonly used chemotherapy regimens was assessed in patients with… Expand
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Highly Cited
1997
Highly Cited
1997
The Raf family of protein kinases display differences in their abilities to promote the entry of quiescent NIH 3T3 cells into the… Expand
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Highly Cited
1996
Highly Cited
1996
Flavopiridol (L86-8275), a N-methylpiperidinyl, chlorophenyl flavone, can inhibit cell cycle progression in either G1 or G2 and… Expand
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Highly Cited
1996
Highly Cited
1996
The mdm-2 gene encodes a 90-kDa polypeptide that binds specifically to the p53 tumor suppressor protein. This physical… Expand
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Highly Cited
1996
Highly Cited
1996
The tumor suppressor p53 contributes to maintaining genome stability by inducing a cell cycle arrest or apoptosis in response to… Expand
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Highly Cited
1995
Highly Cited
1995
DNA-damaging agents induce a p53-dependent G1 arrest that may be critical for p53-mediated tumor suppression. It has been… Expand
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Highly Cited
1994
Highly Cited
1994
The present study assessed the role of the p53 tumor suppressor gene in cell cycle arrest and apoptosis following treatment of… Expand
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Highly Cited
1990
Highly Cited
1990
alpha factor is a negative growth factor and differentiation factor that induces G1 arrest and increases transcription of mating… Expand
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