Negative Regulation of G1 Phase

Known as: G1 Arrest, G1 Block 
G1 Arrest consists of cellular biochemical mechanisms, responsive to diverse governing conditions (DNA damage, contact inhibition, growth factors… (More)
National Institutes of Health

Related topics

Related topics

24 relations
Alvocidib HydrochlorideCDK inhibitor R547CDKN1A geneCDKN1A wt Allele
(More)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
BRAF mutation predicts sensitivity to MEK inhibition
The kinase pathway comprising RAS, RAF, mitogen-activated protein kinase kinase (MEK) and extracellular signal regulated kinase… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
Mechanisms linking mitogenic and growth inhibitory cytokine signaling and the cell cycle have not been fully elucidated in either… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Distinct Initiation and Maintenance Mechanisms Cooperate to Induce G1 Cell Cycle Arrest in Response to DNA Damage
DNA damage causes stabilization of p53, leading to G1 arrest through induction of p21cip1. As this process requires transcription… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest.
The ansamycin antibiotics, herbimycin A (HA) and geldanamycin (GM), bind to a conserved pocket in heat shock protein 90 (Hsp90… (More)
  • figure 1
  • figure 3
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.
Flavopiridol (L86-8275), a N-methylpiperidinyl, chlorophenyl flavone, can inhibit cell cycle progression in either G1 or G2 and… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest.
The tumor suppressor p53 contributes to maintaining genome stability by inducing a cell cycle arrest or apoptosis in response to… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein.
The mdm-2 gene encodes a 90-kDa polypeptide that binds specifically to the p53 tumor suppressor protein. This physical… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
p21 is necessary for the p53-mediated G1 arrest in human cancer cells.
DNA-damaging agents induce a p53-dependent G1 arrest that may be critical for p53-mediated tumor suppression. It has been… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.
The present study assessed the role of the p53 tumor suppressor gene in cell cycle arrest and apoptosis following treatment of… (More)
Is this relevant?
Highly Cited
1990
Highly Cited
1990
Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2
alpha factor is a negative growth factor and differentiation factor that induces G1 arrest and increases transcription of mating… (More)
Is this relevant?