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CDK inhibitor R547

Known as: CDKI R547, Cyclin Dependent Kinase Inhibitor R547, Cyclin-Dependent Kinase Inhibitor R547 
An orally bioavailable diaminopyrimidine compound and a cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. CDKs are ATP… 
National Institutes of Health

Related topics

Related topics

5 relations
Cyclin-Dependent KinasesNCIt Antineoplastic Agent TerminologyNegative Regulation of G1 PhaseNegative Regulation of G2 to M Transition

Papers overview

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2018
2018
The effect of R547, a cyclin dependent kinase inhibitor, on hepatocellular carcinoma cell death
2016
2016
Abstract 2821: Characterization of CDK inhibitors in a biochemical assay using a comprehensive panel of human CDK-cyclin complexes
Members of the family of cyclin dependent kinases (CDKs) have been recognized as pivotal regulators of cell cycle progression for… 
2015
2015
In silico 3D structure modeling and inhibitor binding studies of human male germ cell-associated kinase
Human male germ cell-associated kinase (hMAK) is an androgen-inducible gene in prostate epithelial cells, and it acts as a… 
2013
2013
The effect of dual ligand-targeted micelles on the delivery and efficacy of poorly soluble drug for cancer therapy
Abstract We prepared and evaluated transferrin (Tf) and monoclonal antibody (mAb) 2C5-modified dual ligand-targeted poly(ethylene… 
2010
2010
In Vitro Synthesis of Sindbis Virus Genomic and Subgenomic RNAs: Influence of nsP4 Mutations and Nucleoside Triphosphate Concentrations
ABSTRACT Two positive-strand mRNAs are made in Sindbis virus-infected cells, the genomic (G) RNA and the subgenomic (SG) RNA. In… 
2006
2006
281 POSTER A phase I study of R547, a novel cyclin dependent kinase inhibitor, in patients (pts) with advanced cancer: preliminary results
2003
2003
Expression and Activity of the CDK Inhibitor p57Kip2 in Chondrocytes Undergoing Hypertrophic Differentiation
Growth plates ofp57‐null mice exhibit several abnormalities, including loss of collagen type X (CollX) expression. The phenotypic… 
2000
2000
Expression of CDKI p27Kip1 in trophoblastic neoplasm.
OBJECTIVE To evaluate the role of p27Kip1 in tumorigenesis and the development of trophoblastic cell disease. METHODS Using… 
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