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CDK inhibitor R547

Known as: CDKI R547, Cyclin Dependent Kinase Inhibitor R547, Cyclin-Dependent Kinase Inhibitor R547 
An orally bioavailable diaminopyrimidine compound and a cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. CDKs are ATP… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
The study of marine microbial ecology has been completely transformed by molecular and genomic data: after centuries of relative… Expand
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Review
2014
Review
2014
Breast cancer is the most common cancer in women worldwide. Understanding the biology of this malignant disease is a prerequisite… Expand
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2013
2013
Abstract We prepared and evaluated transferrin (Tf) and monoclonal antibody (mAb) 2C5-modified dual ligand-targeted poly(ethylene… Expand
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2012
2012
RB+/− individuals develop retinoblastoma and, subsequently, many other tumors. The Rb relatives p107 and p130 protect the tumor… Expand
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Highly Cited
2011
Highly Cited
2011
BackgroundHigh-throughput measurement technologies produce data sets that have the potential to elucidate the biological impact… Expand
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2007
2007
3528 Background: R547, a potent inhibitor of CDKs 1, 2, 4, 7, and 9, has shown broad antitumor activity in preclinical models… Expand
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2006
2006
The cyclin-dependent protein kinases are key regulators of cell cycle progression. Aberrant expression or altered activity of… Expand
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2006
2006
The cyclin-dependent kinases (CDKs) and their cyclin partners are key regulators of the cell cycle. Since deregulation of CDKs is… Expand
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2004
2004
UNLABELLED Growth plates of p57-null mice exhibit several abnormalities, including loss of collagen type X (CollX) expression… Expand
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Highly Cited
2003
Highly Cited
2003
Thyroid hormone regulates early postnatal Sertoli cell proliferation. Transient neonatal hypothyroidism allows prolonged… Expand
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