CDK inhibitor R547

Known as: CDKI R547, Cyclin Dependent Kinase Inhibitor R547, Cyclin-Dependent Kinase Inhibitor R547 
An orally bioavailable diaminopyrimidine compound and a cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. CDKs are ATP… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2006-2013
01220062013

Papers overview

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2014
2014
In this study, transferrin (Tf)-modified poly(ethylene glycol)-phosphatidylethanolamine (mPEG-PE) micelles loaded with the poorly… (More)
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2013
2013
We prepared and evaluated transferrin (Tf) and monoclonal antibody (mAb) 2C5-modified dual ligand-targeted poly(ethylene glycol… (More)
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2012
2012
RB+/− individuals develop retinoblastoma and, subsequently, many other tumors. The Rb relatives p107 and p130 protect the tumor… (More)
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2011
2011
High-throughput measurement technologies produce data sets that have the potential to elucidate the biological impact of disease… (More)
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2011
2011
Melanoma cells are resistant to transforming growth factor-β (TGFβ)-induced cell-cycle arrest. In this study, we investigated a… (More)
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2010
2010
Two positive-strand mRNAs are made in Sindbis virus-infected cells, the genomic (G) RNA and the subgenomic (SG) RNA. In mosquito… (More)
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2009
2009
A genomics-based approach to identify pharmacodynamic biomarkers was used for a cyclin-dependent kinase inhibitory drug. R547 is… (More)
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2006
2006
The cyclin-dependent protein kinases are key regulators of cell cycle progression. Aberrant expression or altered activity of… (More)
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2006
2006
The cyclin-dependent kinases (CDKs) and their cyclin partners are key regulators of the cell cycle. Since deregulation of CDKs is… (More)
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