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The study of marine microbial ecology has been completely transformed by molecular and genomic data: after centuries of relative… Expand Breast cancer is the most common cancer in women worldwide. Understanding the biology of this malignant disease is a prerequisite… Expand Abstract We prepared and evaluated transferrin (Tf) and monoclonal antibody (mAb) 2C5-modified dual ligand-targeted poly(ethylene… Expand BackgroundHigh-throughput measurement technologies produce data sets that have the potential to elucidate the biological impact… Expand A genomics-based approach to identify pharmacodynamic biomarkers was used for a cyclin-dependent kinase inhibitory drug. R547 is… Expand 3528 Background: R547, a potent inhibitor of CDKs 1, 2, 4, 7, and 9, has shown broad antitumor activity in preclinical models… Expand The cyclin-dependent protein kinases are key regulators of cell cycle progression. Aberrant expression or altered activity of… Expand The cyclin-dependent kinases (CDKs) and their cyclin partners are key regulators of the cell cycle. Since deregulation of CDKs is… Expand Growth plates ofp57‐null mice exhibit several abnormalities, including loss of collagen type X (CollX) expression. The phenotypic… Expand Thyroid hormone regulates early postnatal Sertoli cell proliferation. Transient neonatal hypothyroidism allows prolonged… Expand