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CDK inhibitor R547

Known as: CDKI R547, Cyclin Dependent Kinase Inhibitor R547, Cyclin-Dependent Kinase Inhibitor R547 
An orally bioavailable diaminopyrimidine compound and a cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. CDKs are ATP… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
The study of marine microbial ecology has been completely transformed by molecular and genomic data: after centuries of relative… Expand
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Review
2014
Review
2014
Breast cancer is the most common cancer in women worldwide. Understanding the biology of this malignant disease is a prerequisite… Expand
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2013
2013
Abstract We prepared and evaluated transferrin (Tf) and monoclonal antibody (mAb) 2C5-modified dual ligand-targeted poly(ethylene… Expand
Highly Cited
2011
Highly Cited
2011
BackgroundHigh-throughput measurement technologies produce data sets that have the potential to elucidate the biological impact… Expand
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2009
2009
A genomics-based approach to identify pharmacodynamic biomarkers was used for a cyclin-dependent kinase inhibitory drug. R547 is… Expand
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2007
2007
3528 Background: R547, a potent inhibitor of CDKs 1, 2, 4, 7, and 9, has shown broad antitumor activity in preclinical models… Expand
Highly Cited
2006
Highly Cited
2006
The cyclin-dependent protein kinases are key regulators of cell cycle progression. Aberrant expression or altered activity of… Expand
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Highly Cited
2006
Highly Cited
2006
The cyclin-dependent kinases (CDKs) and their cyclin partners are key regulators of the cell cycle. Since deregulation of CDKs is… Expand
2004
2004
Growth plates ofp57‐null mice exhibit several abnormalities, including loss of collagen type X (CollX) expression. The phenotypic… Expand
Highly Cited
2003
Highly Cited
2003
Thyroid hormone regulates early postnatal Sertoli cell proliferation. Transient neonatal hypothyroidism allows prolonged… Expand
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