Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 205,667,724 papers from all fields of science
Search
Sign In
Create Free Account
CDK inhibitor R547
Known as:
CDKI R547
, Cyclin Dependent Kinase Inhibitor R547
, Cyclin-Dependent Kinase Inhibitor R547
Expand
An orally bioavailable diaminopyrimidine compound and a cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. CDKs are ATP…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
5 relations
Cyclin-Dependent Kinases
NCIt Antineoplastic Agent Terminology
Negative Regulation of G1 Phase
Negative Regulation of G2 to M Transition
Expand
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Exploring the inhibitory activity of valproic acid against the HDAC family using an MMGBSA approach
Y. Sixto-López
,
M. Bello
,
J. Correa-Basurto
Journal of Computer-Aided Molecular Design
2020
Corpus ID: 212718772
Valproic acid (VPA) is a compound currently used in clinical practice for the treatment of epilepsy as well as bipolar and mood…
Expand
Review
2017
Review
2017
Marine Protists Are Not Just Big Bacteria
P. Keeling
,
J. Campo
Current Biology
2017
Corpus ID: 207052528
Review
2014
Review
2014
Signaling pathways in breast cancer: therapeutic targeting of the microenvironment.
A. H. Nwabo Kamdje
,
P. F. Seke Etet
,
L. Vecchio
,
J. Muller
,
M. Krampera
,
K. Lukong
Cellular signalling
2014
Corpus ID: 41719315
2013
2013
The effect of dual ligand-targeted micelles on the delivery and efficacy of poorly soluble drug for cancer therapy
R. Sawant
,
Aditi Jhaveri
,
A. Koshkaryev
,
Farooq Qureshi
,
V. Torchilin
Journal of drug targeting
2013
Corpus ID: 21770648
Abstract We prepared and evaluated transferrin (Tf) and monoclonal antibody (mAb) 2C5-modified dual ligand-targeted poly(ethylene…
Expand
2009
2009
Preclinical biomarkers for a cyclin-dependent kinase inhibitor translate to candidate pharmacodynamic biomarkers in phase I patients
W. Berkofsky-Fessler
,
T. Q. Nguyen
,
+11 authors
H. Hilton
Molecular Cancer Therapeutics
2009
Corpus ID: 7409644
A genomics-based approach to identify pharmacodynamic biomarkers was used for a cyclin-dependent kinase inhibitory drug. R547 is…
Expand
2007
2007
A phase I study of R547, a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs)
S. Diab
,
S. Eckhardt
,
+7 authors
S. Papadimitrakopoulou
2007
Corpus ID: 59589421
3528 Background: R547, a potent inhibitor of CDKs 1, 2, 4, 7, and 9, has shown broad antitumor activity in preclinical models…
Expand
Highly Cited
2006
Highly Cited
2006
In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials
W. Depinto
,
Xin-jie Chu
,
+17 authors
D. Heimbrook
Molecular Cancer Therapeutics
2006
Corpus ID: 24039117
The cyclin-dependent protein kinases are key regulators of cell cycle progression. Aberrant expression or altered activity of…
Expand
Highly Cited
2006
Highly Cited
2006
Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant…
Xin-jie Chu
,
W. Depinto
,
+18 authors
N. Fotouhi
Journal of medicinal chemistry
2006
Corpus ID: 19469225
The cyclin-dependent kinases (CDKs) and their cyclin partners are key regulators of the cell cycle. Since deregulation of CDKs is…
Expand
2004
2004
Expression and Activity of the CDK Inhibitor p57Kip2 in Chondrocytes Undergoing Hypertrophic Differentiation
M. Stewart
,
Renata Kadlcek
,
Paul D. Robbins
,
J. MacLeod
,
R. T. Ballock
Journal of bone and mineral research : the…
2004
Corpus ID: 25605785
Growth plates ofp57‐null mice exhibit several abnormalities, including loss of collagen type X (CollX) expression. The phenotypic…
Expand
Highly Cited
2003
Highly Cited
2003
Thyroid hormone regulates the cell cycle inhibitor p27Kip1 in postnatal murine Sertoli cells.
D. R. Holsberger
,
S. Jirawatnotai
,
H. Kiyokawa
,
P. Cooke
Endocrinology
2003
Corpus ID: 13520256
Thyroid hormone regulates early postnatal Sertoli cell proliferation. Transient neonatal hypothyroidism allows prolonged…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
,
Terms of Service
, and
Dataset License
ACCEPT & CONTINUE