• Publications
  • Influence
Recent advances with liposomes as pharmaceutical carriers
  • V. Torchilin
  • Medicine
  • Nature Reviews Drug Discovery
  • 1 February 2005
TLDR
For further successful development of this field, promising trends must be identified and exploited, albeit with a clear understanding of the limitations of these approaches. Expand
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
TLDR
Delivery may be less efficient in cranial tumors than in subcutaneous tumors, delivery may be reduced during tumor regression induced by hormonal ablation, and permeability to a molecule is independent of pore cutoff size as long as the diameter of the molecule is much less than the pore diameter. Expand
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
TLDR
The PEG‐PE's activity to prolong the circulation time of liposomes is greater than that of the ganglioside GM1, awell‐described glycolipid with this activity. Expand
Structure and design of polymeric surfactant-based drug delivery systems.
  • V. Torchilin
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 15 June 2001
TLDR
The review concentrates on the use of polymeric micelles as pharmaceutical carriers and the basic mechanisms underlying micelle longevity and steric protection in vivo are considered with a special emphasis on long circulating drug delivery systems. Expand
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
TLDR
Tumor vessels in the model found that tumor vessels in this model were permeable to liposomes of up to 400 nm in diameter, suggesting that the cutoff size of the pores is between 400 and 600nm in diameter. Expand
TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors
TLDR
It is demonstrated that relatively large drug carriers, such as 200-nm liposomes, can also be delivered into cells by TAT peptide attached to the liposome surface, confirming the energy-independent character of this process. Expand
Targeted pharmaceutical nanocarriers for cancer therapy and imaging
TLDR
This review attempts to summarize currently available information regarding targeted pharmaceutical nanocarriers for cancer therapy and imaging, as well as different ways to target tumors via specific ligands and via the stimuli sensitivity of the carriers. Expand
Multifunctional nanocarriers.
TLDR
Current status and possible future directions in the emerging area of multifunctional nanocarriers with primary attention on the combination of such properties as longevity, targetability, intracellular penetration and contrast loading are considered. Expand
Tumor delivery of macromolecular drugs based on the EPR effect.
  • V. Torchilin
  • Medicine
  • Advanced drug delivery reviews
  • 18 March 2011
TLDR
The role of the EPR effect in the intratumoral delivery of protein and peptide drugs, macromolecular drugs and drug-loaded long-circulating pharmaceutical nanocarriers is briefly discussed together with some additional opportunities for drug delivery arising from the initial EPReffect-mediated accumulation of drug-containing macromolescular systems in tumors. Expand
Cell-penetrating peptides: breaking through to the other side.
TLDR
The rationales for the design of 'smart' pharmaceutical nanocarriers in which the cell-penetrating properties are hidden until triggered by exposure to appropriate environmental conditions (e.g., a particular pH, temperature, or enzyme level) are discussed. Expand
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