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CDKN1A gene

Known as: cyclin-dependent kinase inhibitor 1A (CDKN1A) gene, CIP1, WILDTYPE p53-ACTIVATED FRAGMENT 1 
This gene is a regulator of cell cycle progression at the G1 phase of the cell cycle.
National Institutes of Health

Related topics

Related topics

6 relations
Beckwith-Wiedemann SyndromeCell Cycle ControlNegative Regulation of G1 PhaseOncogene Protein p21(ras)

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CDKN1A wt Allele

Papers overview

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2008
2008
Activation of Protein Kinase G Increases the Expression of p 21 CIP 1 , p 27 KIP 1 , and Histidine Triad Protein 1 through Sp 1
The anticancer role of cyclic guanosine 3¶,5¶-monophosphate (cGMP)–dependent protein kinase G (PKG) has become of considerable… 
2006
2006
p 53 Suppression of Arsenite-Induced Mitotic Catastrophe Is Mediated by p 21 CIP 1 / WAF 1
Arsenic trioxide, an acute promyelocytic leukemia chemotherapeutic, may be an efficacious treatment for other cancers… 
Review
2005
Review
2005
Arabidopsis COP 1 protein specifically interacts in vitro with a cytoskeleton-associated protein , CIP 1 ( signal transduction / light regulation / coiled coil / plant development / subcellular…
Arabidopsis COP1 acts inside the nucleus to suppress photomorphogenic cellular development, and light inactivation of COP1 may… 
2005
2005
Induction of p 21 Cip 1-mediated G 2 / M arrest in H 2 O 2-treated lens epithelial cells
Reactive oxygen species (ROS), including the superoxide anion, hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals are natural… 
2004
2004
P 21 Cip 1 Is a Critical Mediator of the Cytotoxic Action of Thymidylate Synthase Inhibitors in Colorectal Carcinoma Cells
  • 2004
  • Corpus ID: 28138272
We have demonstrated previously that interferon (IFN)sensitizes human colon carcinoma cell lines to the cytotoxic effects of 5… 
2001
2001
The prognostic significance of DNA topoisomerase II-alpha (Ki-S1), p21/Cip-1, and p27/Kip-1 protein immunoexpression in oligodendrogliomas.
OBJECTIVE To evaluate a possible association between clinical outcome of patients with oligodendroglioma and expression of 2… 
2001
2001
p 53-independent Induction of Apoptosis in Human Melanoma Cells by a bcl-2 / bcl-xL Bispecific Antisense Oligonucleotide 1
Mutations in the p53 tumor suppressor gene are implicated in defective apoptotic response of tumors to genotoxic damage and, thus… 
2000
2000
Comparative evaluation of the expression of cell cycle regulating proteins: cyclin D1, P53 and P21 (WAF1) in colorectal cancer.
Cyclin D1, P53 and P21 (WAF1) are cell cycle regulating proteins, playing a crucial role in oncogenesis of a large number of… 
1999
1999
The C-terminal Domain of p 21 Inhibits Nucleotide Excision Repair In Vitro and In Vivo
The protein p21Cip1, Waf1, Sdi1 is a potent inhibitor of cyclin-dependent kinases (CDKs). p21 can also block DNA replication… 
1996
1996
Sites and types of UV-induced mutations leading to inactivation of the growth-arresting activity in p21 (sdi1/cip1/waf1) cDNA.
The p53-regulated gene product p21 (sdi1,cip1,waf1) negatively regulates cell growth and has been suggested to be a potential…