Skip to search formSkip to main contentSkip to account menu

CDKN1A wt Allele

Known as: Cyclin-Dependent Kinase Inhibitor 1A wt Allele, CAP20, P21 
Human CDKN1A wild-type allele is located in the vicinity of 6p21.2 and is approximately 9 kb in length. This allele, which encodes cyclin-dependent… 
National Institutes of Health

Related topics

Related topics

14 relations
6p21.2ATM Signaling PathwayBeckwith-Wiedemann SyndromeCalcineurin Pathway

Broader (1)

CDKN1A gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
P21 (WAF1) expression in colorectal cancer: correlation with P53 and cyclin D1 expression, clinicopathological parameters and prognosis.
P21 (WAF1), P53 and cyclin D1 belong to the cell cycle-regulating family of proteins, and the loss of activity of proteins P53… 
2000
2000
DNA damage-related gene expression as biomarkers to assess cellular response after gamma irradiation of a human lymphoblastoid cell line
Since defects in molecular mechanisms controlling DNA repair, cell cycle checkpoint and apoptosis could modify cellular… 
1999
1999
The Role of the Smad3 Protein in Phorbol Ester-induced Promoter Expression*
The Sp1 transcription factor plays an important role in mediating the p53-independent activation of the p21 WAF1 (WAF1) promoter… 
1998
1998
Contribution of protein kinase C to p53-dependent WAF1 induction pathway after heat treatment in human glioblastoma cell lines.
To examine whether protein kinase C (PKC) contributes to p53-dependent WAF1 induction after heat treatment, the effects of… 
1997
1997
WAF1/CIP1 protein expression in human breast tumors
WAF1/CIP1 is a cyclin-dependent kinase inhibitor which isdirectly induced by p53 and negatively controls cellproliferation. To… 
1997
1997
Altered WAF1 genes do not play a role in abnormal cell cycle regulation in breast cancers lacking p53 mutations.
Seventy-five to 80% of breast cancers are negative for p53 gene mutations. We have investigated the possibility that altered WAF1… 
Highly Cited
1996
Highly Cited
1996
p53-dependent Induction of WAF1 by Heat Treatment in Human Glioblastoma Cells*
Induction of WAF1 expression was investigated after heat treatment (44°C, 30 min) in two human glioblastoma cell lines with the… 
Highly Cited
1996
Highly Cited
1996
Functional Analysis of a p21WAF1,CIP1,SDI1 Mutant (Arg94 → Trp) Identified in a Human Breast Carcinoma
Human p21 (also known as WAF1, CIP1, or SDI1) is a dual inhibitor of cyclin dependent kinases (CDKs) and the replication factor… 
Highly Cited
1995
Highly Cited
1995
Effects of cell cycle, wild-type p53 and DNA damage on p21CIP1/Waf1 expression in human breast epithelial cells.
In this study we examine the relationship between p21CIP1/Waf1 (CIP1), a 21 kDa protein that binds to and modulates the activity… 
1994
1994
Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells.
Transforming growth factor beta (TGF beta) is an important regulator of cellular proliferation. In normal ovarian epithelial… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)