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Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila
Drosophila Piwi-family proteins have been implicated in transposon control. Here, we examine piwi-interacting RNAs (piRNAs) associated with each Drosophila Piwi protein and find that Piwi andExpand
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Role for a bidentate ribonuclease in the initiation step of RNA interference
RNA interference (RNAi) is the mechanism through which double-stranded RNAs silence cognate genes. In plants, this can occur at both the transcriptional and the post-transcriptional levels; however,Expand
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An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
In a diverse group of organisms that includes Caenorhabditis elegans , Drosophila, planaria, hydra, trypanosomes, fungi and plants, the introduction of double-stranded RNAs inhibits gene expressionExpand
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Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence
Cellular senescence is an extremely stable form of cell cycle arrest that limits the proliferation of damaged cells and may act as a natural barrier to cancer progression. In this study, we describeExpand
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Argonaute2 Is the Catalytic Engine of Mammalian RNAi
Gene silencing through RNA interference (RNAi) is carried out by RISC, the RNA-induced silencing complex. RISC contains two signature components, small interfering RNAs (siRNAs) and Argonaute familyExpand
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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
THE division cycle of eukaryotic cells is regulated by a family of protein kinases known as the cyclin-dependent kinases (CDKs)1,2. The sequential activation of individual members of this family andExpand
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Specialized piRNA Pathways Act in Germline and Somatic Tissues of the Drosophila Ovary
In Drosophila gonads, Piwi proteins and associated piRNAs collaborate with additional factors to form a small RNA-based immune system that silences mobile elements. Here, we analyzed nine DrosophilaExpand
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A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice.
piRNAs and Piwi proteins have been implicated in transposon control and are linked to transposon methylation in mammals. Here we examined the construction of the piRNA system in the restrictedExpand
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Sorting of Small RNAs into Arabidopsis Argonaute Complexes Is Directed by the 5′ Terminal Nucleotide
Argonaute (AGO) proteins recruit small RNAs to form the core of RNAi effector complexes. Arabidopsis encodes ten AGO proteins and a large network of small RNAs. How these small RNAs are sorted intoExpand
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A germline-specific class of small RNAs binds mammalian Piwi proteins
Small RNAs associate with Argonaute proteins and serve as sequence-specific guides to regulate messenger RNA stability, protein synthesis, chromatin organization and genome structure. In animals,Expand
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