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Integrated genomic characterization of endometrial carcinoma
  • D. Levine, Gad Stacey B. Kristian Eric Andrey Carrie Mike Cyriac Getz Gabriel Cibulskis Lander Sivachenko Sougnez L, +271 authors H. Sofia
  • Biology, Medicine
  • Nature
  • 1 May 2013
The genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours, and these features are classified into four categories: POLE ultramutated, microsatellite instability hypermutated, copy- number low, and copy-number high. Expand
Oncogenic pathway signatures in human cancers as a guide to targeted therapies
It is shown that gene expression signatures can be identified that reflect the activation status of several oncogenic pathways and linked with sensitivity to therapeutics that target components of the pathway provides an opportunity to make use of these oncogens pathway signatures to guide the use of targeted therapeutics. Expand
Integrated Genomic Analyses of Ovarian Carcinoma
It is reported that high-grade serous ovarian cancer is characterized by TP53 mutations in almost all tumours (96%); low prevalence but statistically recurrent somatic mutations in nine further genes including NF1, BRCA1,BRCA2, RB1 and CDK12; 113 significant focal DNA copy number aberrations; and promoter methylation events involving 168 genes. Expand
Rethinking ovarian cancer: recommendations for improving outcomes
Nine major recommendations that should be taken to improve the outcome for women with ovarian cancer are outlined in this Opinion article. Expand
The Immune Landscape of Cancer
An extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA identifies six immune subtypes that encompass multiple cancer types and are hypothesized to define immune response patterns impacting prognosis. Expand
Comprehensive Characterization of Cancer Driver Genes and Mutations
This study reports a PanCancer and PanSoftware analysis spanning 9,423 tumor exomes (comprising all 33 of The Cancer Genome Atlas projects) and using 26 computational tools to catalog driver genes and mutations, identifying 299 driver genes with implications regarding their anatomical sites and cancer/cell types. Expand
Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells
Results show that CD133 expression in ovarian cancer is directly regulated by epigenetic modifications and support the idea thatCD133 demarcates an ovarian cancer-initiating cell population. Expand
Three Biomarkers Identified from Serum Proteomic Analysis for the Detection of Early Stage Ovarian Cancer
These biomarkers demonstrated the potential to improve the detection of early stage ovarian cancer by demonstrating the sensitivity and specificity of a multivariate model combining the three biomarkers. Expand
Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies
Clinicians should be aware of the increased risk of specific subtypes of ovarian cancer in women with endometriosis, and future efforts should focus on understanding the mechanisms that might lead to malignant transformation of endometRIosis so as to help identify subsets of women at increased riskof ovarian cancer. Expand
Oncogenic Signaling Pathways in The Cancer Genome Atlas
This work charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Expand