E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts

@article{Frame2006E2F1IM,
  title={E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts},
  author={Fiona M. Frame and Harry A Rogoff and Mary Theresa Pickering and W. Douglas Cress and Timothy F. Kowalik},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={3258-3266}
}
Deregulation of the Rb/E2F pathway in human fibroblasts results in an E2F1-mediated apoptosis dependent on Atm, Nbs1, Chk2 and p53. Here, we show that E2F1 expression results in MRN foci formation, which is independent of the Nbs1 interacting region and the DNA-binding domain of E2F1. E2F1-induced MRN foci are similar to irradiation-induced foci (IRIF) that result from double-strand DNA breaks because they correlate with 53BP1 and γH2AX foci, do not form in NBS cells, do form in AT cells and do… CONTINUE READING

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