Age-related clonal hematopoiesis associated with adverse outcomes.
- S. Jaiswal, P. Fontanillas, B. Ebert
- MedicineNew England Journal of Medicine
- 24 December 2014
Age-related clonal hematopoiesis is a common condition that is associated with increases in the risk of hematologic cancer and in all-cause mortality, with the latter possibly due to an increased risk of cardiovascular disease.
Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning
Genes implicated in DLBCL outcome included some that regulate responses to B-cell–receptor signaling, critical serine/threonine phosphorylation pathways and apoptosis, and identify rational targets for intervention.
Clinical effect of point mutations in myelodysplastic syndromes.
- R. Bejar, K. Stevenson, B. Ebert
- Medicine, BiologyNew England Journal of Medicine
- 30 June 2011
Mutations in TP53, EZH2, ETV6, RUNX1, and ASXL1 are predictors of poor overall survival in patients with myelodysplastic syndromes, independently of established risk factors.
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.
- E. Weisberg, P. Manley, J. Griffin
- Biology, ChemistryCancer Cell
- 1 February 2005
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.
- A. Ferrando, D. Neuberg, A. Look
- BiologyCancer Cell
- 1 February 2002
Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes
- B. Chapuy, C. Stewart, M. Shipp
- Biology, MedicineNature Network Boston
- 30 April 2018
A comprehensive genetic analysis of 304 primary DLBCLs identified low-frequency alterations, captured recurrent mutations, somatic copy number alterations, and structural variants, and defined coordinate signatures in patients with available outcome data to provide a roadmap for an actionableDLBCL classification.
SF3B1 and other novel cancer genes in chronic lymphocytic leukemia.
- Lili Wang, M. Lawrence, Catherine J. Wu
- Medicine, BiologyNew England Journal of Medicine
- 1 December 2011
This study defines the landscape of somatic mutations in chronic lymphocytic leukemia and highlights pre-mRNA splicing as a critical cellular process contributing to chronic lymphocrytic leukemia.
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large…
- Michael R. Green, S. Monti, M. Shipp
- BiologyBlood
- 28 October 2010
High-resolution copy number data with transcriptional profiles are integrated and identified the immunoregulatory genes, PD-L1 andPD-L2, as key targets at the 9p24.1 amplification peak in HL and MLBCL cell lines, defining the PD-1 pathway and JAK2 as complementary rational therapeutic targets.
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease
- S. Jaiswal, P. Natarajan, B. Ebert
- Medicine, BiologyNew England Journal of Medicine
- 21 June 2017
The presence of CHIP in peripheral‐blood cells was associated with nearly a doubling in the risk of coronary heart disease in humans and with accelerated atherosclerosis in mice.
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