Enkephalin, Leucine-2-Alanine

Known as: DADLE, Enkephalin, 5-Leucine-2-Alanine, 5 Leucine 2 Alanine Enkephalin 
A delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.

Topic mentions per year

Topic mentions per year

1962-2017
010203019622017

Papers overview

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2002
2002
Chronic opioid receptor (OR) activation by morphine causes distinct cellular adaptations responsible for the development of… (More)
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Highly Cited
2001
Highly Cited
2001
Stimulation of the delta(1)-opioid receptor confers cardioprotection to the ischemic myocardium. We examined the role of protein… (More)
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2001
2001
Two series of experiments were performed in the isolated perfused rat heart to determine the role of kappa- and delta-opioid… (More)
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2001
2001
Electroacupuncture (EA) is used in traditional Chinese medicine to treat arrhythmias, hypertension and myocardial ischemia. Our… (More)
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2000
2000
OBJECTIVES The objective of this study was to examine whether the delta (delta) opioid receptor isoform is expressed in the human… (More)
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Highly Cited
1993
Highly Cited
1993
mu opiate receptors recognize morphine with high affinity. A 2.1-kb rat brain cDNA whose predicted translation product displays… (More)
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1991
1991
The distribution and postnatal ontogeny of opioid receptors have been investigated using in vitro quantitative receptor… (More)
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1989
1989
Multiple modulatory effects of opioids on the duration of the calcium component of the action potential (APD) of dorsal-root… (More)
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Highly Cited
1988
Highly Cited
1988
Acutely, morphine and D-ala2-D-leu-enkephalin (DADLE) inhibited adenylate cyclase in vitro in locus coeruleus (LC), dorsal raphe… (More)
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Highly Cited
1987
Highly Cited
1987
In neuronal cells, opioid peptides and opiates inhibit neurotransmitter release, which is a calcium-dependent process. They also… (More)
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