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Enkephalin, Leucine-2-Alanine

Known as: DADLE, Enkephalin, 5-Leucine-2-Alanine, 5 Leucine 2 Alanine Enkephalin 
A delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.
National Institutes of Health

Related topics

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11 relations

Narrower (2)

BW-180Cdalargin, destyrosyl-
In BloodProcess of secretionagonistsanalogs & derivatives

Papers overview

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Highly Cited
2002
Highly Cited
2002
Chronic Morphine Treatment Inhibits Opioid Receptor Desensitization and Internalization
Chronic opioid receptor (OR) activation by morphine causes distinct cellular adaptations responsible for the development of… 
Highly Cited
2001
Highly Cited
2001
Kappa- but not delta-opioid receptors mediate effects of ischemic preconditioning on both infarct and arrhythmia in rats.
Two series of experiments were performed in the isolated perfused rat heart to determine the role of kappa- and delta-opioid… 
Highly Cited
1998
Highly Cited
1998
Isolation and partial characterization of an opioid-like 88 kDa hibernation-related protein.
Highly Cited
1986
Highly Cited
1986
Characterization of Opioid Receptors Modulating Noradrenaline Release in the Hippocampus of the Rabbit
Noradrenaline (NA) release and its modulation via presynaptic opioid receptors were studied in rabbit hippocampal slices, which… 
Highly Cited
1985
Highly Cited
1985
Interaction of Opiates with Opioid Binding Sites in the Bovine Adrenal Medulla: I. Interaction with δ and μ Sites
Abstract: In the present study we examined the interaction of opiates with the δ and μ opioid binding sites in the bovine adrenal… 
Highly Cited
1982
Highly Cited
1982
Enkephalin-containing neurons in substantia gelatinosa of spinal trigeminal complex: Ultrastructure and synaptic interaction with primary sensory afferents
Highly Cited
1981
Highly Cited
1981
Effects of [D‐Ala2]‐Methionine‐Enkephalin on Blood Pressure, Heart Rate, and Baroreceptor Reflex Sensitivity in Conscious Cats
SUMMARY Effects of intracerebroventricular (i.c.r.) injection of [D-Ala'1-methionine-enkephalinamide (DAME) on blood pressure (BP… 
Highly Cited
1980
Highly Cited
1980
Substance P- and enkephalin-containing neurones in the rat trigeminal system
Highly Cited
1980
Highly Cited
1980
Post-training intraperitoneal administration of leu-enkephalin and beta-endorphin causes retrograde amnesia for two different tasks in rats.
Highly Cited
1978
Highly Cited
1978
Analgesia by enkephalins injected into the nucleus reticularis gigantocellularis of rat medulla oblongata.
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