FAQ

Enkephalin, Leucine-2-Alanine

Known as: DADLE, Enkephalin, 5-Leucine-2-Alanine, 5 Leucine 2 Alanine Enkephalin 
A delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.

Topic mentions per year

Topic mentions per year

1962-2017
010203019622017

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11 relations

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BW-180C
In BloodProcess of secretionadministration & dosageagonists
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Enkephalin, Leucine-2-Alanine
physiological aspects
agonists
chemical synthesis
standards characteristics
Process of secretion

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2002
2002
Chronic morphine treatment inhibits opioid receptor desensitization and internalization.
Chronic opioid receptor (OR) activation by morphine causes distinct cellular adaptations responsible for the development of… (More)
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Highly Cited
2001
Highly Cited
2001
Essential activation of PKC-delta in opioid-initiated cardioprotection.
Stimulation of the delta(1)-opioid receptor confers cardioprotection to the ischemic myocardium. We examined the role of protein… (More)
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2001
2001
Kappa- but not delta-opioid receptors mediate effects of ischemic preconditioning on both infarct and arrhythmia in rats.
Two series of experiments were performed in the isolated perfused rat heart to determine the role of kappa- and delta-opioid… (More)
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2001
2001
Rostral ventrolateral medullary opioid receptor subtypes in the inhibitory effect of electroacupuncture on reflex autonomic response in cats.
Electroacupuncture (EA) is used in traditional Chinese medicine to treat arrhythmias, hypertension and myocardial ischemia. Our… (More)
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2000
2000
Delta opioid receptor stimulation mimics ischemic preconditioning in human heart muscle.
OBJECTIVES The objective of this study was to examine whether the delta (delta) opioid receptor isoform is expressed in the human… (More)
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Highly Cited
1993
Highly Cited
1993
mu opiate receptor: cDNA cloning and expression.
mu opiate receptors recognize morphine with high affinity. A 2.1-kb rat brain cDNA whose predicted translation product displays… (More)
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1991
1991
Ontogeny and distribution of opioid receptors in the rat brainstem.
The distribution and postnatal ontogeny of opioid receptors have been investigated using in vitro quantitative receptor… (More)
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1989
1989
Dual opioid modulation of the action potential duration of mouse dorsal root ganglion neurons in culture.
Multiple modulatory effects of opioids on the duration of the calcium component of the action potential (APD) of dorsal-root… (More)
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Highly Cited
1988
Highly Cited
1988
Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus.
Acutely, morphine and D-ala2-D-leu-enkephalin (DADLE) inhibited adenylate cyclase in vitro in locus coeruleus (LC), dorsal raphe… (More)
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Highly Cited
1987
Highly Cited
1987
The GTP-binding protein, Go, regulates neuronal calcium channels.
In neuronal cells, opioid peptides and opiates inhibit neurotransmitter release, which is a calcium-dependent process. They also… (More)
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