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A note on the use of picric acid-paraformaldehyde-glutaraldehyde fixative for correlated light and electron microscopic immunocytochemistry
TLDR
The buffered picric acid paraformaldehyde fixative has been supplemented with glutaraldehyde and used as primary fixative for the perfusion of rat brains and it is suggested that the procedure may be useful for electron-microscopic sampling of immunoreactive structures occurring infrequently over a large area or for the electron- microscopically classified neurons. Expand
Calcitonin gene-related peptide promotes mechanical nociception by potentiating release of substance P from the spinal dorsal horn in rats
TLDR
It is suggested that in the rat spinal dorsal horn, CGRP potentiates the release of substance P from the primary afferent terminal and promotes the transmission of nociceptive information induced by mechanical noxious stimuli. Expand
Release of substance P from the spinal dorsal horn is enhanced in polyarthritic rats
TLDR
The results suggest that the facilitated release of iSP from the primary afferent terminals in the spinal dorsal horn in polyarthritic rats possibly plays a role in transmission of chronic pain of inflamed joints. Expand
Loss of α-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function
TLDR
Evidence is provided for a role of polyglutamylation of α-tubulin in vivo, as a molecular traffic sign for targeting of KIF1 kinesin required for continuous synaptic transmission within the mammalian nervous system. Expand
Low-threshold potassium channels and a low-threshold calcium channel regulate Ca2+ spike firing in the dendrites of cerebellar Purkinje neurons: a modeling study
TLDR
A detailed compartmental model of a Purkinje neuron is built by incorporating two types of low-threshold Ca2+ channel (T-type and class-E, or R-type) and two types (A and D-type), in addition to another eight voltage-gated channel types, using a compartmentalmodel neuron simulator. Expand
Region-specific expression of subunits of ionotropic glutamate receptors (AMPA-type, KA-type and NMDA receptors) in the rat spinal cord with special reference to nociception.
TLDR
The present study showed that the expression pattern of the glutamate receptors in the spinal sensory neurons differs considerably from that of spinal motor neurons, and that there are at least two kinds of glutamergic systems which regulate motor neurons: via AMPA-type receptors and via NMDA receptors. Expand
SCRAPPER-Dependent Ubiquitination of Active Zone Protein RIM1 Regulates Synaptic Vesicle Release
TLDR
In neurons from Scrapper-knockout (SCR-KO) mice, RIM1 had a longer half-life with significant reduction in ubiquitination, indicating that SCRAPPER is the predominant ubiquitin ligase that mediates RIM 1 degradation. Expand
Two components of exocytosis and endocytosis in phaeochromocytoma cells studied using caged Ca2+ compounds.
TLDR
Changes in membrane capacitance evoked by the rapid photolysis of a caged Ca2+ compound, DM‐nitrophen or nitrophenyl‐EGTA, were investigated in undifferentiated PC12 cells and suggest that the two vesicles belong to two distinct secretory pathways. Expand
Subcellular localization of benzodiazepine/GABAA receptors in the cerebellum of rat, cat, and monkey using monoclonal antibodies
TLDR
The results demonstrate that different neuronal types express the GABAA/benzodiazepine receptor/chloride channel complex to different degrees, and the distribution of the receptor complex suggests that the cellular topography of GABAergic influence is not governed by the precise spatial arrangement of the receptors but by the exact placement of the GABA-releasing terminals, a characteristic of the cerebellar circuit. Expand
Distribution of somatostatin in the frog brain, Rana catesbiana, in relation to location of catecholamine‐containing neuron system
TLDR
The distribution of somatostatin‐immunoreactive structures in the central nervous system of the bull frog was studied, using the indirect immunofluorescence technique of Coons and co‐workers, and an extensive network of SRIF‐positive fibers was found in most parts of thecentral nervous system. Expand
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