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Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area
The ultrastructural bases for these interactions in rat are investigated by examining the synaptic associations between prefrontal cortical terminals labeled with anterograde markers and neuronal processes containing immunoreactivity for the catecholamine synthesizing enzyme, tryosine hydroxylase. Expand
The anatomy of neuropeptide-y-containing neurons in rat brain
The extremely high concentrations and widespread distribution of neuropeptide Y in the central nervous system suggests a number of important physiological roles for this neurotransmitter candidate. Expand
Topography of serotonin neurons in the dorsal raphe nucleus that send axon collaterals to the rat prefrontal cortex and nucleus accumbens
The results suggest a more prominent input to the Acb from both 5-HT-ir and non-5- HT-ir neurons in the caudal aspect of the DRN and further indicate that while most 5-hydroxytryptamine neurons project differentially to both forebrain regions, a few cells also show collateralization to the MPFC and Acb. Expand
Electron Microscopic Preembedding Double-Immunostaining Methods
During the last decade, immunocytochemistry has become one of the major tools for the light and electron microscopic identification of neurons containing classical transmitters and neuropeptidesExpand
The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons
Electro microscopic immunocytochemistry with an N-terminal domain anti-peptide antibody is used to examine the subcellular distribution of DAT in the rat SN and dorsolateral striatum and suggests that this transporter is strategically located to facilitate uptake of dopamine and neurotoxins into distal dendritic and axonal processes of nigrostriatal dopaminergic neurons. Expand
Ultrastructural localization of D2 receptor-like immunoreactivity in midbrain dopamine neurons and their striatal targets
Electron microscopic examination of the medial substantia nigra and ventral tegmental area revealed readily detectable peroxidase immunoreactivity for the D2 peptide, primarily associated with the smooth endoplasmic reticulum and plasmalemmal surfaces of dendrites, consistent with the localization of a dopamine D2 receptor-like protein that is strategically positioned to subserve autoreceptor functions. Expand
Optimization of differential immunogold-silver and peroxidase labeling with maintenance of ultrastructure in brain sections before plastic embedding
The conditions needed for optimal immunogold-silver labeling of antigens while maintaining the ultrastructural morphology in brain are defined and the necessity for controlled silver intensification for light or electron microscopic differentiation of immunogolds and peroxidase reaction products and for optimal subcellular resolution is established. Expand
The Localization of the Brain-Specific Inorganic Phosphate Transporter Suggests a Specific Presynaptic Role in Glutamatergic Transmission
The results provide anatomic evidence of a specific presynaptic role for BNPI in glutamatergic neurotransmission, consistent with the phenotype of eat-4 mutants and suggests a mechanism for neural activity to regulate the function of BnPI. Expand
Serotonin axon terminals in the ventral tegmental area of the rat: fine structure and synaptic input to dopaminergic neurons
The results suggest that 5-HT neurons innervate both dopaminergic and non-dopaminergic neurons in the VTA and may influence mesocortical and mesolimbic efferent systems through synaptic as well as non-synaptic mechanisms. Expand
In the rat medial nucleus accumbens, hippocampal and catecholaminergic terminals converge on spiny neurons and are in apposition to each other
Analysis of the ultrastructure and synaptic associations of hippocampal afferents, as well as their relation to catecholaminergic terminals, in the medial Acb of adult rats showed that 25% of associations formed by degenerating hippocampal terminals involved convergent inputs with TH-labeled terminals on the same postsynaptic structure. Expand