I. Izquierdo

Publications612
h-index85
Citations30,100
Highly Influential Citations1,086
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Protein Kinase
Most cellular effects of cAMP are mediated through PKA by serine or threonine phosphorylation of target proteins. Human Protein Kinase A (cAMP Ser/T hr Protein Kinase Family) is an inactive…
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Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats.
TLDR
It is reported that a late memory consolidation phase of an inhibitory avoidance learning is regulated by an hippocampal cAMP signaling pathway that is activated, at least in part, by D1/D5 receptors.
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Persistence of Long-Term Memory Storage Requires a Late Protein Synthesis- and BDNF- Dependent Phase in the Hippocampus
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Physiology of the prion protein.
TLDR
A unified view of functional properties of PrP(C) indicates that the prion protein is a dynamic cell surface platform for the assembly of signaling modules, based on which selective interactions with many ligands and transmembrane signaling pathways translate into wide-range consequences upon both physiology and behavior.
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Dopamine Controls Persistence of Long-Term Memory Storage
TLDR
The persistence of LTM depends on activation of VTA/hippocampus dopaminergic connections and can be specifically modulated by manipulating this system at definite post-learning time points.
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BDNF is essential to promote persistence of long-term memory storage
TLDR
It is demonstrated that intrahippocampal delivery of BDNF reverses the deficit in memory persistence caused by inhibition of hippocampal protein synthesis, and induces memory persistence by itself, transforming a nonlasting LTM trace into a persistent one in an ERK-dependent manner.
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Cellular prion protein binds laminin and mediates neuritogenesis.
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Two Time Periods of Hippocampal mRNA Synthesis Are Required for Memory Consolidation of Fear-Motivated Learning
TLDR
It is shown that LTM formation of a one-trial inhibitory avoidance training in rats, a hippocampal-dependent form of contextual fear conditioning, depends on two consolidation periods requiring synthesis of new mRNAs, and suggests that the two time periods of anisomycin-induced amnesia depend at least in part on new mRNA synthesis.
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Different molecular cascades in different sites of the brain control memory consolidation
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The ubiquitin–proteasome cascade is required for mammalian long‐term memory formation
TLDR
It is shown that the hippocampal blockade of this proteolytic pathway is also required for the formation of long‐term memory in the rat, indicating that the ubiquitin–proteasome cascade is crucial for the establishment of LTM in the behaving animal.
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