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Ethanol, 3,4-Methylenedioxymethamphetamine (Ecstasy) and Their Combination: Long-Term Behavioral, Neurochemical and Neuropharmacological Effects in the Rat
It is likely that the psycho(patho)logical problems reported by ecstasy users drinking alcohol are not solely due to the consumption of MDMA, and MDMA–EtOH interactions may have specific long-term consequences on presynaptic modulation of hippocampal 5- HT release, but not necessarily related to MDMA-induced depletion of 5-HT.
Inhibitory potency of choline esterase inhibitors on acetylcholine release and choline esterase activity in fresh specimens of human and rat neocortex.
It is concluded that neocortical ChE concentrations are lower and that ChEIs have weaker indirect (muscarine receptor-mediated) presynaptic inhibitory effects in the human brain, and a combination of ChE is with brain-selective muscarine autoreceptor antagonists might help to improve their clinical efficacy.
Presynaptic opioid receptors on noradrenergic and serotonergic neurons in the human as compared to the rat neocortex
- B. Berger, A. K. Rothmaier, F. Wedekind, J. Zentner, T. Feuerstein, R. Jackisch
- Biology, ChemistryBritish journal of pharmacology
- 1 July 2006
This study provides evidence for significant species differences in opioid receptor‐mediated modulation of NA and 5‐HT‐release in human vs rat neocortex and also the ORL1 receptor seems to be involved in 5-HT release modulation.
Effects of ethanol and ecstasy on conditioned place preference in the rat
The current data are in line with anecdotal reports and one study in humans, indicating that EtOH alters the pharmacological effects of MDMA including self reports of enhanced or prolonged euphoria, and might increase the risk for compulsive use of MDMA.
Functional characterization of muscarinic autoreceptors in rat and human neocortex
- C. Stoll, M. Eltze, G. Lambrecht, J. Zentner, T. Feuerstein, R. Jackisch
- Biology, ChemistryJournal of neurochemistry
- 1 August 2009
Electrically evoked overflow of [3H]acetylcholine in slices of rat neocortex and of human neocortex was used to functionally characterize the muscarinic receptor subtype, which mediates autoinhibition of acetyl choline release in these tissues, lending further support to the development of M2 receptor selective brain penetrating antagonists for application in Alzheimer’s disease.
Adenosine: An endogenous modulator of hippocampal noradrenaline release
Presynaptic P1‐purinoceptors in jejunal branches of the rabbit mesenteric artery and their possible function.
It is suggested that the axon terminals of postganglionic sympathetic neurones in the rabbit mesenteric artery possess P1‐purinoceptors of the A1‐type, and the activation of these presynaptic receptors by endogenous adenosine may inhibit the release of the main neuroeffector transmitter, which is probably ATP.
Characterization of nicotinic receptors inducing noradrenaline release and absence of nicotinic autoreceptors in human neocortex
Effects of ethanol and 3,4-methylenedioxymethamphetamine (MDMA) alone or in combination on spontaneous and evoked overflow of dopamine, serotonin and acetylcholine in striatal slices of the rat brain.
Results support the hypothesis that EtOH may affect the abuse liability of MDMA and show for the first time a local synergistic interaction of EtOH and MDMA on the spontaneous outflow of striatal DA and 5-HT, which could be relevant to the EtOH-induced potentiation of hyperlocomotion in MDMA-treated rats.
Islet-activating protein (pertussis toxin) diminishes α2-adrenoceptor mediated effects on noradrenaline release
- C. Allgaier, T. Feuerstein, R. Jackisch, G. Hertting
- BiologyNaunyn-Schmiedeberg's Archives of Pharmacology
- 1 November 1985
Results provide circumstantial evidence that an inhibitory guanine-nucleotide-binding protein, most probably N1 of a presynaptically located adenylate cyclase, is involved in the α2-autoreceptor mediated modulation of noradrenaline release.