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Genome sequence of the Brown Norway rat yields insights into mammalian evolution
This first comprehensive analysis of the genome sequence of the Brown Norway (BN) rat strain is reported, which is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. Expand
Morphology, physiology, and molecular biology of renin secretion.
Article de synthese sur la renine chez les mammiferes, mecanismes intervenant dans le controle de la secretion de renine, controle local de the liberation of renine. Expand
Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene
The introduction of the mouse Ren-2 renin gene3,1113 into the genome of the rat is described and it is demonstrated that expression of this gene causes severe hypertension. Expand
Lessons from rat models of hypertension: from Goldblatt to genetic engineering.
The comparison of models, and the comparison of treatment effects suggests that end-organ damage critically depends upon not only on the stress imposed by high blood pressure and its underlying biochemical disturbance, but also upon the ability of the organism to recruit adequate 'coping' mechanisms. Expand
Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research
- M. Bader, J. Peters, O. Baltatu, D. Müller, F. Luft, D. Ganten
- Biology, Medicine
- Journal of Molecular Medicine
- 9 March 2001
This review presents some selected aspects of the historical development of this concept and summarizes discoveries relying primarily on animal models which demonstrate that Ang II is generated locally and acts in tissues as a local peptidergic system. Expand
Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats
Comparison of the human and rat genetic maps indicates that BP/SP-1 could reside on human chromosome 17q in a region that also contains the angiotensin l-converting enzyme gene (ACE)8, and is therefore a candidate gene in primary hypertension. Expand
Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning
It is shown that when rat embryonic stem cell-like cells of WKY origin are injected intraportally into fully MHC-mismatched DA rats, they engraft permanently without supplementary host conditioning, which sets the basis for long-term graft acceptance of second-set transplanted WKY cardiac allografts. Expand
Atrial natriuretic factor—a circulating hormone stimulated by volume loading
A sensitive and specific radio-immunoassay for atrial natriuretic factor and its stimulation on volume loading is described and its effects on salt loading and blood volume are described. Expand
NF-kappaB inhibition ameliorates angiotensin II-induced inflammatory damage in rats.
It is demonstrated that the antioxidant pyrrolidine dithiocarbamate inhibits NF-kappaB activity, ameliorates inflammation, and protects against angiotensin II-induced end-organ damage. Expand
Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat
Strong genetic evidence is reported that a gene, Bp1, having a major effect on blood pressure maps to rat chromosome 10 with a LOD score of 5.10 and is closely linked to the rat gene encoding angiotensin-converting enzyme (ACE), an enzyme that plays a major role in blood pressure homeostasis and is an important target of anti-hypertensive drugs. Expand