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Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the development of neuropathic pain
TLDR
Results suggest that MCP-1 produced in the DRG neurons is involved in the development of mechanical allodynia induced by nerve injury. Expand
Interleukin-1 beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices.
TLDR
This work reports the first evidence that IL-1 beta can regulate LTP of synaptic transmission in the hippocampus, and blocks the effect of Lys-D-Pro-Thr, a tripeptide analogue of IL- 1 beta, by concurrent application. Expand
Scratching behavior induced by pruritogenic but not algesiogenic agents in mice.
TLDR
The results suggest that compound 48/80- and substance P-induced scratching of the injected site is due to itch, but not to pain, and that histamine produces itch in the mouse. Expand
Differential contributions of the basolateral and central nuclei of the amygdala in the negative affective component of chemical somatic and visceral pains in rats
TLDR
Results suggest that activation of distinct amygdaloid nuclei could differentially contribute to chemical somatic and visceral noxious stimuli‐induced negative affective, but not sensory components of pains. Expand
Analgesic Effects of Intrathecal Administration of P2Y Nucleotide Receptor Agonists UTP and UDP in Normal and Neuropathic Pain Model Rats
TLDR
Results suggest that the activation of UTP-sensitive P2y2 and/or P2Y4 receptors and the UDP-sensitiveP2Y6receptor, in contrast to P2X receptors, produces inhibitory effects on spinal pain transmission. Expand
Calcitonin gene-related peptide promotes mechanical nociception by potentiating release of substance P from the spinal dorsal horn in rats
TLDR
It is suggested that in the rat spinal dorsal horn, CGRP potentiates the release of substance P from the primary afferent terminal and promotes the transmission of nociceptive information induced by mechanical noxious stimuli. Expand
Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice
TLDR
The results suggest that scratching induced by intradermal injection of 5-HT is itch-associated response, and the 5-ht action may be mediated at least partly by cutaneous 5- HT2 receptors. Expand
Release of substance P from the spinal dorsal horn is enhanced in polyarthritic rats
TLDR
The results suggest that the facilitated release of iSP from the primary afferent terminals in the spinal dorsal horn in polyarthritic rats possibly plays a role in transmission of chronic pain of inflamed joints. Expand
Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice.
TLDR
The results suggest that scratching of the mouse induced by an i.d. injection of SP is itch-associated response, and the SP action may be mediated at least partly by cutaneous NK1 receptors, and mast cells may not be key factors in SP-induced itching. Expand
Cloning and expression of a cDNA for the rat kappa-opioid receptor.
TLDR
Northern blot analysis demonstrated that kappa-opioid receptor mRNA is expressed in a regionally specific manner in rat brain. Expand
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