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International union of pharmacology. XXIII. The angiotensin II receptors.
- M. de Gasparo, K. Catt, T. Inagami, J. Wright, T. Unger
- Biology, Medicine
- Pharmacological reviews
- 1 September 2000
Although AT(1) receptors mediate most of the known actions of Ang II, the AT(2) receptor contributes to the regulation of blood pressure and renal function and the development of specific nonpeptide receptor antagonists has led to major advances in the physiology, pharmacology, and therapy of the renin-angiotensin system. Expand
Quantitative real-time RT-PCR data analysis: current concepts and the novel “gene expression’s CT difference” formula
- J. Schefe, K. Lehmann, I. Buschmann, T. Unger, H. Funke-Kaiser
- Mathematics, Medicine
- Journal of Molecular Medicine
- 14 September 2006
The issue of real-time PCR data analysis and its mathematical background is focused on, offering a general concept for efficient, fast and precise data analysis superior to the commonly used comparative CT and the standard curve method, as it considers individual amplification efficiencies for every PCR. Expand
T-lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance
- U. Kintscher, M. Hartge, +14 authors N. Marx
- Arteriosclerosis, thrombosis, and vascular…
- 1 July 2008
Proinflammatory T-lymphocytes are present in visceral adipose tissue and may contribute to local inflammatory cell activation before the appearance of macrophages, suggesting that these cells could play an important role in the initiation and perpetuation of adipOSE tissue inflammation as well as the development of IR. Expand
Repetitive, episodic hypoxia causes diurnal elevation of blood pressure in rats.
It is hypothesized that repetitive episodic Hypoxia patterned after the hypoxia seen in sleep apnea could contribute to diurnal elevation of blood pressure. Expand
A Novel Signal Transduction Cascade Involving Direct Physical Interaction of the Renin/Prorenin Receptor With the Transcription Factor Promyelocytic Zinc Finger Protein
The data demonstrate the existence of a novel signal transduction pathway involving the ligand renin, RER, and the transcription factor PLZF, which is of physiological and putative pathophysiological relevance. Expand
Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors.
- W. Linz, G. Wiemer, P. Gohlke, T. Unger, B. Schölkens
- Chemistry, Medicine
- Pharmacological reviews
- 1 March 1995
The effect of ACE inhibition in LVH was investigated in rats made hypertensive by aortic banding and ACE inhibition with ramipril, in the antihypertensive dose of 1 mg/kg/day for 6 weeks, prevented the increase in blood pressure and the development of LVH. Expand
Angiotensin AT1/AT2 Receptors: Regulation, Signalling and Function
A role for the AT2 receptor in cardiovascular, brain and renal function as well as in the modulation of various biological processes involved in development, cell differentiation, tissue repair and apoptosis is established. Expand
AT2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism.
Results demonstrate that the effects of AT2 receptor stimulation are mediated by BK and, subsequently, NO because they were abolished by B2 receptor blockade as well as by NO synthase inhibition and losartan increased aortic cGMP most likely by increasing plasma ANG II levels with a subsequent stimulation of At2 receptors. Expand
Carotid chemoreceptors, systemic blood pressure, and chronic episodic hypoxia mimicking sleep apnea.
- E. Fletcher, J. Lesske, R. Behm, C. Miller, H. Stauss, T. Unger
- Journal of applied physiology
- 1 May 1992
It is hypothesized that afferent information from the peripheral chemoreceptors may be necessary to produce diurnal blood pressure elevation in this Hypoxia model, a rat model that responds to repetitive episodic hypoxia with an increase in diurnal systemic blood pressure. Expand
Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity.
SPPARM activity by ARBs could retain the metabolic efficacy of PPARgamma activation with reduction in adverse effects exerting in parallel AT1 receptor blockade, and may provide a new therapeutic option for better cardiovascular risk management in metabolic diseases. Expand