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DCC protein, human

Known as: DCC, Deleted in Colorectal Carcinoma Protein, Netrin Receptor DCC 
Netrin receptor DCC (1447 aa, ~158 kDa) is encoded by the human DCC gene. This protein is involved in both axonal guidance and the regulation of… 
National Institutes of Health

Related topics

Related topics

19 relations
ApoptosisAxonAxon GuidanceDCC gene

Broader (2)

Receptors, Cell SurfaceTumor Suppressor Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo
Localized activation of netrin signaling induces focused F-actin formation and the protrusive force necessary for physical… 
Highly Cited
2012
Highly Cited
2012
The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques
Atherosclerotic plaque formation is fueled by the persistence of lipid-laden macrophages in the artery wall. The mechanisms by… 
Highly Cited
2010
Highly Cited
2010
Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation
Highly Cited
2005
Highly Cited
2005
Phosphatidylinositol transfer protein-α in netrin-1-induced PLC signalling and neurite outgrowth
Neurite extension is essential for wiring the nervous system during development. Although several factors are known to regulate… 
Highly Cited
2003
Highly Cited
2003
The Netrin Receptor UNC-40/DCC Stimulates Axon Attraction and Outgrowth through Enabled and, in Parallel, Rac and UNC-115/AbLIM
Highly Cited
2002
Highly Cited
2002
Rac1 and Cdc42 but Not RhoA or Rho Kinase Activities Are Required for Neurite Outgrowth Induced by the Netrin-1 Receptor DCC (Deleted in Colorectal Cancer) in N1E-115 Neuroblastoma Cells*
Netrins are chemotropic guidance cues that attract or repel growing axons during development. DCC (deleted in colorectalcancer… 
Highly Cited
2001
Highly Cited
2001
Binding of DCC by Netrin-1 to Mediate Axon Guidance Independent of Adenosine A2B Receptor Activation
Netrins stimulate and orient axon growth through a mechanism requiring receptors of the DCC family. It has been unclear, however… 
Highly Cited
2001
Highly Cited
2001
The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation
The expression of DCC (deleted in colorectal cancer) is often markedly reduced in colorectal and other cancers. However, the… 
Highly Cited
2000
Highly Cited
2000
Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor
The netrins, a family of laminin-related secreted proteins, are critical in controlling axon elongation and pathfinding. The DCC… 
Highly Cited
1999
Highly Cited
1999
Altered Midline Axon Pathways and Ectopic Neurons in the Developing Hypothalamus of Netrin-1- and DCC-Deficient Mice
Optic nerve formation in mouse involves interactions between netrin-1 at the optic disk and the netrin-1 receptor DCC (deleted in… 
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