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Tumor Suppressor Proteins

Known as: Tumor Suppressor Protein, Proteins, Tumor Suppressor, Tumor Suppressor Proteins [Chemical/Ingredient] 
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell… 
National Institutes of Health

Related topics

Related topics

50 relations

Narrower (34)

ADAM11 protein, humanBAP1 protein, humanDCC protein, humanDLC-1 (deleted in liver cancer) protein, mouse
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APC protein, humanCDKN1C protein, humanCDKN3 protein, humanCyclin-Dependent Kinase Inhibitor 2A, human
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Broader (1)

Cell Cycle Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli… 
Highly Cited
2003
Highly Cited
2003
Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis
Inactivation of the tumor suppressor p53 by missense mutations is the most frequent genetic alteration in human cancers. The… 
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Review
2001
Review
2001
Regulation and function of the p53 tumor suppressor protein.
Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that… 
Highly Cited
2000
Highly Cited
2000
Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein*
The von Hippel-Lindau tumor suppressor protein (pVHL) has emerged as a key factor in cellular responses to oxygen availability… 
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Highly Cited
2000
Highly Cited
2000
Mechanism of regulation of the hypoxia‐inducible factor‐1α by the von Hippel‐Lindau tumor suppressor protein
In normoxic cells the hypoxia‐inducible factor‐1α (HIF‐1α) is rapidly degraded by the ubiquitin‐proteasome pathway, and… 
Review
1999
Review
1999
Regulation of the p53 Tumor Suppressor Protein*
  • M. Oren
  • The Journal of Biological Chemistry
  • 1999
  • Corpus ID: 2278184
Mutations in the p53 tumor suppressor gene occur in about 50% of all human tumors, making it the most frequent target for genetic… 
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Highly Cited
1995
Highly Cited
1995
Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C
Germ-line mutations of the von Hippel-Lindau tumor suppressor gene (VHL) predispose individuals to a variety of human tumors, and… 
Highly Cited
1993
Highly Cited
1993
Association of the APC tumor suppressor protein with catenins.
Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been… 
Highly Cited
1992
Highly Cited
1992
E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.
The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown… 
Highly Cited
1992
Highly Cited
1992
The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein
In CNS synapses, the synaptic junctional complex with associated postsynaptic density is presumed to contain proteins responsible… 
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