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Tumor Suppressor Proteins
Known as:
Tumor Suppressor Protein
, Proteins, Tumor Suppressor
, Tumor Suppressor Proteins [Chemical/Ingredient]
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Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell…
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National Institutes of Health
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Related topics
Related topics
50 relations
Narrower (34)
ADAM11 protein, human
BAP1 protein, human
DCC protein, human
DLC-1 (deleted in liver cancer) protein, mouse
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APC protein, human
CDKN1C protein, human
CDKN3 protein, human
Cyclin-Dependent Kinase Inhibitor 2A, human
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Broader (1)
Cell Cycle Proteins
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Jean-Philippe Coppé
,
C. Patil
,
+6 authors
J. Campisi
PLoS Biology
2008
Corpus ID: 432143
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli…
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Highly Cited
2007
Highly Cited
2007
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis.
Tsung-Cheng Chang
,
E. Wentzel
,
+11 authors
J. Mendell
Molecules and Cells
2007
Corpus ID: 33356907
Highly Cited
2003
Highly Cited
2003
Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis
S. Kato
,
Shuang-yin Han
,
+4 authors
C. Ishioka
Proceedings of the National Academy of Sciences…
2003
Corpus ID: 16464257
Inactivation of the tumor suppressor p53 by missense mutations is the most frequent genetic alteration in human cancers. The…
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Highly Cited
2000
Highly Cited
2000
Mechanism of regulation of the hypoxia‐inducible factor‐1α by the von Hippel‐Lindau tumor suppressor protein
Keiji Tanimoto
,
Y. Makino
,
T. Pereira
,
L. Poellinger
EMBO Journal
2000
Corpus ID: 19765703
In normoxic cells the hypoxia‐inducible factor‐1α (HIF‐1α) is rapidly degraded by the ubiquitin‐proteasome pathway, and…
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Highly Cited
2000
Highly Cited
2000
Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein*
M. Cockman
,
N. Masson
,
+7 authors
P. Maxwell
Journal of Biological Chemistry
2000
Corpus ID: 44367641
The von Hippel-Lindau tumor suppressor protein (pVHL) has emerged as a key factor in cellular responses to oxygen availability…
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Highly Cited
1997
Highly Cited
1997
β‐catenin is a target for the ubiquitin–proteasome pathway
H. Aberle
,
A. Bauer
,
J. Stappert
,
A. Kispert
,
R. Kemler
1997
Corpus ID: 9561740
β‐catenin is a central component of the cadherin cell adhesion complex and plays an essential role in the Wingless/Wnt signaling…
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Highly Cited
1995
Highly Cited
1995
Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C
A. Kibel
,
O. Iliopoulos
,
J. Decaprio
,
WG Kaelin
Science
1995
Corpus ID: 25410108
Germ-line mutations of the von Hippel-Lindau tumor suppressor gene (VHL) predispose individuals to a variety of human tumors, and…
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Highly Cited
1993
Highly Cited
1993
Association of the APC tumor suppressor protein with catenins.
L. Su
,
B. Vogelstein
,
K. Kinzler
Science
1993
Corpus ID: 45679889
Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been…
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Highly Cited
1993
Highly Cited
1993
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
M. Scheffner
,
J. Huibregtse
,
R. Vierstra
,
P. Howley
Cell
1993
Corpus ID: 27437768
Highly Cited
1992
Highly Cited
1992
E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.
J. Nevins
Science
1992
Corpus ID: 36478257
The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown…
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