Tumor Suppressor Proteins

Known as: Tumor Suppressor Protein, Proteins, Tumor Suppressor, Tumor Suppressor Proteins [Chemical/Ingredient] 
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell… (More)
National Institutes of Health

Papers overview

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Review
2009
Review
2009
In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the… (More)
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Highly Cited
2008
Highly Cited
2008
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli… (More)
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Review
2005
Review
2005
Cells from organisms with renewable tissues can permanently withdraw from the cell cycle in response to diverse stress, including… (More)
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Highly Cited
2005
Highly Cited
2005
The Mixed-Lineage Leukemia (MLL) protein is a histone methyltransferase that is mutated in clinically and biologically… (More)
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Highly Cited
2003
Highly Cited
2003
Inactivation of the tumor suppressor p53 by missense mutations is the most frequent genetic alteration in human cancers. The… (More)
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Highly Cited
2003
Highly Cited
2003
Organ-specific metastasis is governed, in part, by interactions between chemokine receptors on cancer cells and matching… (More)
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Review
2001
Review
2001
Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that… (More)
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Review
2001
Review
2001
The von Hippel-Lindau tumor suppressor protein (pVHL) has been shown to bind directly to the alpha subunits of the heterodimeric… (More)
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Highly Cited
1993
Highly Cited
1993
Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been… (More)
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Highly Cited
1992
Highly Cited
1992
In CNS synapses, the synaptic junctional complex with associated postsynaptic density is presumed to contain proteins responsible… (More)
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