Tumor Suppressor Proteins

Known as: Tumor Suppressor Protein, Proteins, Tumor Suppressor, Tumor Suppressor Proteins [Chemical/Ingredient] 
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell… (More)
National Institutes of Health

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Narrower (33)

ADAM11 protein, humanBAP1 protein, humanDCC protein, humanDLC-1 (deleted in liver cancer) protein, mouse
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APC protein, humanCDKN1C protein, humanCDKN3 protein, humanCyclin-Dependent Kinase Inhibitor 2A, human
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Broader (1)

Cell Cycle Proteins

Papers overview

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Review
2009
Review
2009
Understanding the Warburg effect: the metabolic requirements of cell proliferation.
In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the… (More)
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Highly Cited
2008
Highly Cited
2008
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli… (More)
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Review
2005
Review
2005
Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
Cells from organisms with renewable tissues can permanently withdraw from the cell cycle in response to diverse stress, including… (More)
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Highly Cited
2005
Highly Cited
2005
The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis
The Mixed-Lineage Leukemia (MLL) protein is a histone methyltransferase that is mutated in clinically and biologically… (More)
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Highly Cited
2003
Highly Cited
2003
Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis.
Inactivation of the tumor suppressor p53 by missense mutations is the most frequent genetic alteration in human cancers. The… (More)
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Highly Cited
2003
Highly Cited
2003
Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL
Organ-specific metastasis is governed, in part, by interactions between chemokine receptors on cancer cells and matching… (More)
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Review
2001
Review
2001
Regulation and function of the p53 tumor suppressor protein.
Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that… (More)
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Review
2001
Review
2001
The von Hippel-Lindau tumor suppressor protein.
The von Hippel-Lindau tumor suppressor protein (pVHL) has been shown to bind directly to the alpha subunits of the heterodimeric… (More)
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Highly Cited
1993
Highly Cited
1993
Association of the APC tumor suppressor protein with catenins.
Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been… (More)
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Highly Cited
1992
Highly Cited
1992
The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein
In CNS synapses, the synaptic junctional complex with associated postsynaptic density is presumed to contain proteins responsible… (More)
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