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Tumor Suppressor Proteins

Known as: Tumor Suppressor Protein, Proteins, Tumor Suppressor, Tumor Suppressor Proteins [Chemical/Ingredient] 
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell… 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli… 
Highly Cited
2007
Highly Cited
2003
Highly Cited
2003
Inactivation of the tumor suppressor p53 by missense mutations is the most frequent genetic alteration in human cancers. The… 
Highly Cited
2000
Highly Cited
2000
In normoxic cells the hypoxia‐inducible factor‐1α (HIF‐1α) is rapidly degraded by the ubiquitin‐proteasome pathway, and… 
Highly Cited
2000
Highly Cited
2000
The von Hippel-Lindau tumor suppressor protein (pVHL) has emerged as a key factor in cellular responses to oxygen availability… 
Highly Cited
1997
Highly Cited
1997
β‐catenin is a central component of the cadherin cell adhesion complex and plays an essential role in the Wingless/Wnt signaling… 
Highly Cited
1995
Highly Cited
1995
Germ-line mutations of the von Hippel-Lindau tumor suppressor gene (VHL) predispose individuals to a variety of human tumors, and… 
Highly Cited
1993
Highly Cited
1993
Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been… 
Highly Cited
1992
Highly Cited
1992
The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown…