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Tumor Suppressor Proteins

Known as: Tumor Suppressor Protein, Proteins, Tumor Suppressor, Tumor Suppressor Proteins [Chemical/Ingredient] 
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
BACKGROUND Selinexor, a selective inhibitor of nuclear export compound that blocks exportin 1 (XPO1) and forces nuclear… Expand
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Highly Cited
2008
Highly Cited
2008
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli… Expand
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Highly Cited
2003
Highly Cited
2003
Inactivation of the tumor suppressor p53 by missense mutations is the most frequent genetic alteration in human cancers. The… Expand
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Review
2001
Review
2001
Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that… Expand
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Highly Cited
2000
Highly Cited
2000
The von Hippel-Lindau tumor suppressor protein (pVHL) has emerged as a key factor in cellular responses to oxygen availability… Expand
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Highly Cited
2000
Highly Cited
2000
In normoxic cells the hypoxia‐inducible factor‐1α (HIF‐1α) is rapidly degraded by the ubiquitin‐proteasome pathway, and… Expand
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Highly Cited
1997
Highly Cited
1997
β‐catenin is a central component of the cadherin cell adhesion complex and plays an essential role in the Wingless/Wnt signaling… Expand
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Highly Cited
1993
Highly Cited
1993
Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been… Expand
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Highly Cited
1992
Highly Cited
1992
The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown… Expand
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Highly Cited
1992
Highly Cited
1992
In CNS synapses, the synaptic junctional complex with associated postsynaptic density is presumed to contain proteins responsible… Expand
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