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Tumor Suppressor Proteins

Known as: Tumor Suppressor Protein, Proteins, Tumor Suppressor, Tumor Suppressor Proteins [Chemical/Ingredient] 
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell… 
National Institutes of Health

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Related topics

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Narrower (34)

ADAM11 protein, humanBAP1 protein, humanDCC protein, humanDLC-1 (deleted in liver cancer) protein, mouse
APC protein, humanCDKN1C protein, humanCDKN3 protein, humanCyclin-Dependent Kinase Inhibitor 2A, human

Broader (1)

Cell Cycle Proteins

Papers overview

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Highly Cited
2008
Highly Cited
2008
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli… 
Highly Cited
2007
Highly Cited
2007
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis.
Highly Cited
2003
Highly Cited
2003
Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis
Inactivation of the tumor suppressor p53 by missense mutations is the most frequent genetic alteration in human cancers. The… 
Highly Cited
2000
Highly Cited
2000
Mechanism of regulation of the hypoxia‐inducible factor‐1α by the von Hippel‐Lindau tumor suppressor protein
In normoxic cells the hypoxia‐inducible factor‐1α (HIF‐1α) is rapidly degraded by the ubiquitin‐proteasome pathway, and… 
Highly Cited
2000
Highly Cited
2000
Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein*
The von Hippel-Lindau tumor suppressor protein (pVHL) has emerged as a key factor in cellular responses to oxygen availability… 
Highly Cited
1997
Highly Cited
1997
β‐catenin is a target for the ubiquitin–proteasome pathway
β‐catenin is a central component of the cadherin cell adhesion complex and plays an essential role in the Wingless/Wnt signaling… 
Highly Cited
1995
Highly Cited
1995
Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C
Germ-line mutations of the von Hippel-Lindau tumor suppressor gene (VHL) predispose individuals to a variety of human tumors, and… 
Highly Cited
1993
Highly Cited
1993
Association of the APC tumor suppressor protein with catenins.
Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been… 
Highly Cited
1993
Highly Cited
1993
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
Highly Cited
1992
Highly Cited
1992
E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.
The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown… 
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