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Tumor Suppressor Proteins

Known as: Tumor Suppressor Protein, Proteins, Tumor Suppressor, Tumor Suppressor Proteins [Chemical/Ingredient] 
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell… 
National Institutes of Health

Related topics

Related topics

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Narrower (34)

ADAM11 protein, humanBAP1 protein, humanDCC protein, humanDLC-1 (deleted in liver cancer) protein, mouse
APC protein, humanCDKN1C protein, humanCDKN3 protein, humanCyclin-Dependent Kinase Inhibitor 2A, human

Broader (1)

Cell Cycle Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
In vitro and in vivo anti-melanoma action of metformin.
Review
2004
Review
2004
Cell-cycle targeted therapies.
Highly Cited
2003
Highly Cited
2003
The insulator binding protein CTCF associates with the nuclear matrix.
Review
2001
Review
2001
Why Is p53 Acetylated?
Highly Cited
2001
Highly Cited
2001
The von Hippel-Lindau Tumor Suppressor Protein Mediates Ubiquitination of Activated Atypical Protein Kinase C*
The von Hippel-Lindau tumor-suppressor protein (pVHL) forms a protein complex (VCB-Cul2) with elongin C, elongin B, Cul-2, and… 
Highly Cited
2001
Highly Cited
2001
The PTEN Tumor Suppressor Protein Inhibits Tumor Necrosis Factor-induced Nuclear Factor κB Activity*
Nuclear factor κB (NF-κB) transcriptionally activates genes that promote immunity and cell survival. Activation of NF-κB is… 
Highly Cited
1999
Highly Cited
1999
Tax oncoprotein of HTLV-1 binds to the human homologue of Drosophila discs large tumor suppressor protein, hDLG, and perturbs its function in cell growth control
HTLV-1 Tax oncoprotein interacts with various cellular factors and modulates transcription and the cell cycle. To identify more… 
Highly Cited
1999
Highly Cited
1999
Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers.
The ability to separate the isoforms of human tumour suppressor protein p53 expressed in insect cells using heparin-Sepharose… 
Highly Cited
1996
Highly Cited
1996
Characterisation of human cyclin G1 and G2: DNA damage inducible genes.
Several genes have been identified as targets for transcriptional activation by the p53 tumour suppressor protein. Rodent cyclin… 
Highly Cited
1993
Highly Cited
1993
A structure-function analysis of transcriptional repression mediated by the WT1, Wilms' tumor suppressor protein.
The chromosome 11p13 Wilms' tumor locus (wt1) encodes a zinc finger-containing transcription factor (WT1). WT1 binds to the… 
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