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APC protein, human
Known as:
DP2.5 protein, human
, Adenomatous Polyposis Coli Protein
, adenomatous polyposis coli protein, human
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Adenomatous polyposis coli protein (2843 aa, ~312 kDa) is encoded by the human APC gene. This protein is involved in both tumor suppression and the…
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National Institutes of Health
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Related topics
Related topics
16 relations
ALK Pathway
APC gene
Adenomatous Polyposis Coli
Beta-Catenin Accumulation Pathway
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Broader (1)
Adenomatous Polyposis Coli Protein
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability.
K. Kroboth
,
I. P. Newton
,
+4 authors
I. Näthke
Molecular biology of the cell
2007
Corpus ID: 38146813
Most sporadic colorectal tumors carry truncation mutations in the adenomatous polyposis coli (APC) gene. The APC protein is…
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Highly Cited
2005
Highly Cited
2005
Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin.
Violet Votin
,
W. Nelson
,
A. Barth
Journal of cell science
2005
Corpus ID: 2642468
Neuronal morphogenesis involves the initial formation of neurites and then differentiation of neurites into axons and dendrites…
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Highly Cited
2005
Highly Cited
2005
Neurite outgrowth involves adenomatous polyposis coli protein and β-catenin
Violet Votin
,
W. Nelson
,
A. Barth
Journal of Cell Science
2005
Corpus ID: 15487462
Neuronal morphogenesis involves the initial formation of neurites and then differentiation of neurites into axons and dendrites…
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Highly Cited
2001
Highly Cited
2001
Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3β phosphorylation
J. Zumbrunn
,
K. Kinoshita
,
A. Hyman
,
I. Näthke
Current Biology
2001
Corpus ID: 15004529
Highly Cited
2001
Highly Cited
2001
Pin1 regulates turnover and subcellular localization of β-catenin by inhibiting its interaction with APC
A. Ryo
,
Masafumi Nakamura
,
G. Wulf
,
Y. Liou
,
K. Lu
Nature Cell Biology
2001
Corpus ID: 664553
Phosphorylation on a serine or threonine residue preceding proline (Ser/Thr-Pro) is a key regulatory mechanism, and the…
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Highly Cited
2001
Highly Cited
2001
Axin-dependent Phosphorylation of the Adenomatous Polyposis Coli Protein Mediated by Casein Kinase 1ε*
B. Rubinfeld
,
D. Tice
,
P. Polakis
The Journal of Biological Chemistry
2001
Corpus ID: 31868395
Axin and the adenomatous polyposis coli protein (APC) interact to down-regulate the proto-oncogene β-catenin. We show that…
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Review
2001
Review
2001
The adenomatous polyposis coli protein: in the limelight out at the edge.
D. Dikovskaya
,
J. Zumbrunn
,
G. A. Penman
,
I. Näthke
Trends in cell biology
2001
Corpus ID: 23108668
Highly Cited
2001
Highly Cited
2001
CTNNB1 mutations and β‐catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1 †
T. Devereux
,
M. Stern
,
+4 authors
J. Taylor
Molecular carcinogenesis
2001
Corpus ID: 40005487
β‐Catenin plays a key role in the Wnt signaling pathway, and mutations of CTNNB1, the gene that encodes β‐catenin, have been…
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Highly Cited
1999
Highly Cited
1999
The Ubiquitin-Proteasome Pathway and Serine Kinase Activity Modulate Adenomatous Polyposis Coli Protein-mediated Regulation of β-Catenin-Lymphocyte Enhancer-binding Factor Signaling*
V. Easwaran
,
V. Song
,
P. Polakis
,
S. Byers
The Journal of Biological Chemistry
1999
Corpus ID: 41736304
The tumor suppressor function of the adenomatous polyposis coli protein (APC) depends, in part, on its ability to bind and…
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Highly Cited
1995
Highly Cited
1995
The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin
J. Daniel
,
A. Reynolds
Molecular and cellular biology
1995
Corpus ID: 1227584
The tyrosine kinase substrate p120cas (CAS), which is structurally similar to the cell adhesion proteins beta-catenin and…
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