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APC protein, human

Known as: DP2.5 protein, human, Adenomatous Polyposis Coli Protein, adenomatous polyposis coli protein, human 
Adenomatous polyposis coli protein (2843 aa, ~312 kDa) is encoded by the human APC gene. This protein is involved in both tumor suppression and the… 
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Most sporadic colorectal tumors carry truncation mutations in the adenomatous polyposis coli (APC) gene. The APC protein is… 
Highly Cited
2005
Highly Cited
2005
Neuronal morphogenesis involves the initial formation of neurites and then differentiation of neurites into axons and dendrites… 
Highly Cited
2005
Highly Cited
2005
Neuronal morphogenesis involves the initial formation of neurites and then differentiation of neurites into axons and dendrites… 
Highly Cited
2001
Highly Cited
2001
Phosphorylation on a serine or threonine residue preceding proline (Ser/Thr-Pro) is a key regulatory mechanism, and the… 
Highly Cited
2001
Highly Cited
2001
Axin and the adenomatous polyposis coli protein (APC) interact to down-regulate the proto-oncogene β-catenin. We show that… 
Highly Cited
2001
Highly Cited
2001
β‐Catenin plays a key role in the Wnt signaling pathway, and mutations of CTNNB1, the gene that encodes β‐catenin, have been… 
Highly Cited
1999
Highly Cited
1999
The tumor suppressor function of the adenomatous polyposis coli protein (APC) depends, in part, on its ability to bind and… 
Highly Cited
1995
Highly Cited
1995
The tyrosine kinase substrate p120cas (CAS), which is structurally similar to the cell adhesion proteins beta-catenin and…