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APC protein, human

Known as: DP2.5 protein, human, Adenomatous Polyposis Coli Protein, adenomatous polyposis coli protein, human 
Adenomatous polyposis coli protein (2843 aa, ~312 kDa) is encoded by the human APC gene. This protein is involved in both tumor suppression and the… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Most sporadic colorectal tumors carry truncation mutations in the adenomatous polyposis coli (APC) gene. The APC protein is… Expand
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Highly Cited
2005
Highly Cited
2005
Neuronal morphogenesis involves the initial formation of neurites and then differentiation of neurites into axons and dendrites… Expand
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2003
2003
Wnt signaling stabilizes beta-catenin, which in turn influences the transcription of Wnt-responsive genes in conjunction with T… Expand
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Highly Cited
2001
Highly Cited
2001
Phosphorylation on a serine or threonine residue preceding proline (Ser/Thr-Pro) is a key regulatory mechanism, and the… Expand
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Highly Cited
2001
Highly Cited
2001
Truncation mutations in the adenomatous polyposis coli protein (APC) are responsible for familial polyposis, a form of inherited… Expand
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Review
2001
Review
2001
Truncation mutations in the adenomatous polyposis coli protein (APC) are responsible for familial and sporadic colonic tumours… Expand
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Highly Cited
2001
Highly Cited
2001
Axin and the adenomatous polyposis coli protein (APC) interact to down-regulate the proto-oncogene beta-catenin. We show that… Expand
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2001
2001
beta-Catenin plays a key role in the Wnt signaling pathway, and mutations of CTNNB1, the gene that encodes beta-catenin, have… Expand
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1999
1999
The tumor suppressor function of the adenomatous polyposis coli protein (APC) depends, in part, on its ability to bind and… Expand
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Highly Cited
1995
Highly Cited
1995
The tyrosine kinase substrate p120cas (CAS), which is structurally similar to the cell adhesion proteins beta-catenin and… Expand
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