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APC protein, human

Known as: DP2.5 protein, human, Adenomatous Polyposis Coli Protein, adenomatous polyposis coli protein, human 
Adenomatous polyposis coli protein (2843 aa, ~312 kDa) is encoded by the human APC gene. This protein is involved in both tumor suppression and the… 
National Institutes of Health

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Related topics

16 relations
ALK PathwayAPC geneAdenomatous Polyposis ColiBeta-Catenin Accumulation Pathway

Broader (1)

Adenomatous Polyposis Coli Protein

Papers overview

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2014
2014
Expression of APC protein during tongue malignant transformation in galectin-3-deficient mice challenged by the carcinogen 4-nitroquniline-n-oxide.
Galectin-3 (Gal3) has been implicated in the development of different tumors because of its involvement in the Wnt signaling… 
2009
2009
[Expression of beta-catenin and adenomatous polyposis coli protein and correlation between them in the development of mouse tooth germ].
OBJECTIVE To examine the distributions of beta-catenin and adenomatous polyposis coli (APC) protein in the tooth germ, and obtain… 
2009
2009
Regulation of adenomatous polyposis coli protein during growth factor mediated cell extension
2006
2006
Membrane Localization of Adenomatous Polyposis Coli Protein at Cellular Protrusions
Adenomatous polyposis coli protein (APC) translocates to, and stabilizes, the plus-ends of microtubules. In microtubule-dependent… 
2006
2006
[Dynamic changes of adenomatous polyposis coli protein and glycogen synthase kinase 3beta in the repair of the injured airway epithelial cells in smoking mice].
To investigate the roles of adenomatous polyposis coli (APC) protein and glycogen synthase kinase 3beta (GSK3beta) of smoking… 
Highly Cited
2005
Highly Cited
2005
The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis.
The adenomatous polyposis coli (APC) gene, whose mutations are responsible for familial adenomatous polyposis, is a major… 
2005
2005
Tumor-associated NH2-terminal fragments are the most stable part of the adenomatous polyposis coli protein and can be regulated by interactions with COOH-terminal domains.
Truncation mutations in the adenomatous polyposis coli (APC) gene are responsible for familial and sporadic colorectal cancer… 
2003
2003
Requirement for a nuclear function of beta-catenin in Wnt signaling.
Wnt signaling stabilizes beta-catenin, which in turn influences the transcription of Wnt-responsive genes in conjunction with T… 
2001
2001
The use of coiled-coil interactions for the analysis and micropreparative isolation of adenomatous polyposis coli protein complexes.
The coiled coil is a common structural motif found both as the dominant structure in fibrous proteins and as an oligomerization… 
1999
1999
Adenomatous polyposis coli protein (APC)-independent regulation of beta-catenin/Tcf-4 mediated transcription in intestinal cells.
Alterations in the transcriptional activity of the beta-catenin-Tcf complex have been associated with the earlier stages of… 
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