FAQ

APC protein, human

Known as: DP2.5 protein, human, Adenomatous Polyposis Coli Protein, adenomatous polyposis coli protein, human 
Adenomatous polyposis coli protein (2843 aa, ~312 kDa) is encoded by the human APC gene. This protein is involved in both tumor suppression and the… (More)

Topic mentions per year

Topic mentions per year

1988-2016
0204019882016

Related topics

Related topics

14 relations
ALK PathwayAPC geneAdenomatous Polyposis ColiBinding Proteins
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Broader (1)

Adenomatous Polyposis Coli Protein

Related mentions per year

Related mentions per year

1941-2018
19401960198020002020
APC protein, human
Signal Transduction
Cell Adhesion
Binding Proteins
Adenomatous Polyposis Coli
APC gene

Papers overview

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Highly Cited
2008
Highly Cited
2008
Genomic stability and tumour suppression by the APC/C cofactor Cdh1
The anaphase promoting complex or cyclosome (APC/C) is a ubiquitin protein ligase that, together with Cdc20 or Cdh1, targets cell… (More)
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Highly Cited
2007
Highly Cited
2007
Sequential E2s Drive Polyubiquitin Chain Assembly on APC Targets
The anaphase-promoting complex (APC), or cyclosome, is an E3 ubiquitin-protein ligase that collaborates with E2 ubiquitin… (More)
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Highly Cited
2006
Highly Cited
2006
The Processivity of Multiubiquitination by the APC Determines the Order of Substrate Degradation
The anaphase-promoting complex (APC) coordinates mitosis and G1 by sequentially promoting the degradation of key cell-cycle… (More)
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Highly Cited
2004
Highly Cited
2004
Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.
Skp2 and its cofactor Cks1 are the substrate-targeting subunits of the SCF(Skp2-Cks1) (Skp1/Cul1/F-box protein) ubiquitin ligase… (More)
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Highly Cited
2004
Highly Cited
2004
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration.
Rho family GTPases, particularly Rac1 and Cdc42, are key regulators of cell polarization and directional migration. Adenomatous… (More)
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Highly Cited
2004
Highly Cited
2004
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation.
The transcriptional coactivator beta-catenin mediates Wnt growth factor signaling. In the absence of a Wnt signal, casein kinase… (More)
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Highly Cited
2000
Highly Cited
2000
Adenomatous Polyposis Coli (APC) Protein Moves along Microtubules and Concentrates at Their Growing Ends in Epithelial Cells
Adenomatous polyposis coli (APC) tumor suppressor protein has been shown to be localized near the distal ends of microtubules… (More)
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Highly Cited
2000
Highly Cited
2000
Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover.
Mutational inactivation of the APC gene is a key early event in the development of familial adenomatous polyposis and colon… (More)
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Highly Cited
1996
Highly Cited
1996
Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.
The adenomatous polyposis coli gene (APC) is mutated in familial adenomatous polyposis and in sporadic colorectal tumors, and its… (More)
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Highly Cited
1996
Highly Cited
1996
Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes.
The Wnt-1 proto-oncogene induces the accumulation of beta-catenin and plakoglobin, two related proteins that associate with and… (More)
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