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APC protein, human

Known as: DP2.5 protein, human, Adenomatous Polyposis Coli Protein, adenomatous polyposis coli protein, human 
Adenomatous polyposis coli protein (2843 aa, ~312 kDa) is encoded by the human APC gene. This protein is involved in both tumor suppression and the… Expand
National Institutes of Health

Related topics

Related topics

16 relations
ALK PathwayAPC geneAdenomatous Polyposis ColiBeta-Catenin Accumulation Pathway
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Broader (1)

Adenomatous Polyposis Coli Protein

Papers overview

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Highly Cited
2007
Highly Cited
2007
Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability.
Most sporadic colorectal tumors carry truncation mutations in the adenomatous polyposis coli (APC) gene. The APC protein is… Expand
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Highly Cited
2005
Highly Cited
2005
Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin.
Neuronal morphogenesis involves the initial formation of neurites and then differentiation of neurites into axons and dendrites… Expand
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2003
2003
Requirement for a nuclear function of beta-catenin in Wnt signaling.
Wnt signaling stabilizes beta-catenin, which in turn influences the transcription of Wnt-responsive genes in conjunction with T… Expand
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Highly Cited
2001
Highly Cited
2001
Pin1 regulates turnover and subcellular localization of β-catenin by inhibiting its interaction with APC
Phosphorylation on a serine or threonine residue preceding proline (Ser/Thr-Pro) is a key regulatory mechanism, and the… Expand
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Highly Cited
2001
Highly Cited
2001
Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3β phosphorylation
Truncation mutations in the adenomatous polyposis coli protein (APC) are responsible for familial polyposis, a form of inherited… Expand
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Review
2001
Review
2001
The adenomatous polyposis coli protein: in the limelight out at the edge.
Truncation mutations in the adenomatous polyposis coli protein (APC) are responsible for familial and sporadic colonic tumours… Expand
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Highly Cited
2001
Highly Cited
2001
Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon.
Axin and the adenomatous polyposis coli protein (APC) interact to down-regulate the proto-oncogene beta-catenin. We show that… Expand
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2001
2001
CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1.
beta-Catenin plays a key role in the Wnt signaling pathway, and mutations of CTNNB1, the gene that encodes beta-catenin, have… Expand
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1999
1999
The ubiquitin-proteasome pathway and serine kinase activity modulate adenomatous polyposis coli protein-mediated regulation of beta-catenin-lymphocyte enhancer-binding factor signaling.
The tumor suppressor function of the adenomatous polyposis coli protein (APC) depends, in part, on its ability to bind and… Expand
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Highly Cited
1995
Highly Cited
1995
The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin.
The tyrosine kinase substrate p120cas (CAS), which is structurally similar to the cell adhesion proteins beta-catenin and… Expand
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