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APC protein, human
Known as:
DP2.5 protein, human
, Adenomatous Polyposis Coli Protein
, adenomatous polyposis coli protein, human
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Adenomatous polyposis coli protein (2843 aa, ~312 kDa) is encoded by the human APC gene. This protein is involved in both tumor suppression and the…Â
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Topic mentions per year
Topic mentions per year
1988-2016
0
20
40
1988
2016
Related topics
Related topics
14 relations
ALK Pathway
APC gene
Adenomatous Polyposis Coli
Binding Proteins
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Broader (1)
Adenomatous Polyposis Coli Protein
Related mentions per year
Related mentions per year
1941-2018
1940
1960
1980
2000
2020
APC protein, human
Signal Transduction
Cell Adhesion
Binding Proteins
Adenomatous Polyposis Coli
APC gene
Papers overview
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Highly Cited
2008
Highly Cited
2008
Genomic stability and tumour suppression by the APC/C cofactor Cdh1
Irene GarcÃa-Higuera
,
Eusebio Manchado
,
+4 authors
Marcos Malumbres
Nature Cell Biology
2008
The anaphase promoting complex or cyclosome (APC/C) is a ubiquitin protein ligase that, together with Cdc20 or Cdh1, targets cell…Â
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Highly Cited
2007
Highly Cited
2007
Sequential E2s Drive Polyubiquitin Chain Assembly on APC Targets
Monica C. Rodrigo-Brenni
,
David O. Morgan
Cell
2007
The anaphase-promoting complex (APC), or cyclosome, is an E3 ubiquitin-protein ligase that collaborates with E2 ubiquitin…Â
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Highly Cited
2006
Highly Cited
2006
The Processivity of Multiubiquitination by the APC Determines the Order of Substrate Degradation
Michael Rape
,
Sashank K. Reddy
,
Marc W Kirschner
Cell
2006
The anaphase-promoting complex (APC) coordinates mitosis and G1 by sequentially promoting the degradation of key cell-cycle…Â
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Highly Cited
2004
Highly Cited
2004
Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.
Tarig Bashir
,
N Valerio Dorrello
,
Virginia Amador
,
Daniele Guardavaccaro
,
Michele Pagano
Nature
2004
Skp2 and its cofactor Cks1 are the substrate-targeting subunits of the SCF(Skp2-Cks1) (Skp1/Cul1/F-box protein) ubiquitin ligase…Â
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Highly Cited
2004
Highly Cited
2004
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration.
Takashi Watanabe
,
Shujie Wang
,
+7 authors
Kozo Kaibuchi
Developmental cell
2004
Rho family GTPases, particularly Rac1 and Cdc42, are key regulators of cell polarization and directional migration. Adenomatous…Â
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Highly Cited
2004
Highly Cited
2004
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation.
Nam-Chul Ha
,
Takashi Tonozuka
,
Jennifer L. Stamos
,
Hee Jung Choi
,
William I Weis
Molecular cell
2004
The transcriptional coactivator beta-catenin mediates Wnt growth factor signaling. In the absence of a Wnt signal, casein kinase…Â
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Highly Cited
2000
Highly Cited
2000
Adenomatous Polyposis Coli (APC) Protein Moves along Microtubules and Concentrates at Their Growing Ends in Epithelial Cells
Yuko Mimori-Kiyosue
,
Nobuyuki Shiina
,
Shoichiro Tsukita
The Journal of cell biology
2000
Adenomatous polyposis coli (APC) tumor suppressor protein has been shown to be localized near the distal ends of microtubules…Â
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Highly Cited
2000
Highly Cited
2000
Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover.
Beric R. Henderson
Nature cell biology
2000
Mutational inactivation of the APC gene is a key early event in the development of familial adenomatous polyposis and colon…Â
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Highly Cited
1996
Highly Cited
1996
Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.
Akihiko Matsumine
,
Akiko Ogai
,
+8 authors
Taishin Akiyama
Science
1996
The adenomatous polyposis coli gene (APC) is mutated in familial adenomatous polyposis and in sporadic colorectal tumors, and its…Â
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Highly Cited
1996
Highly Cited
1996
Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes.
Jackie Papkoff
,
Bonnee Rubinfeld
,
Brian Schryver
,
Pavlos Polakis
Molecular and cellular biology
1996
The Wnt-1 proto-oncogene induces the accumulation of beta-catenin and plakoglobin, two related proteins that associate with and…Â
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