APC protein, human

Known as: DP2.5 protein, human, Adenomatous Polyposis Coli Protein, adenomatous polyposis coli protein, human 
Adenomatous polyposis coli protein (2843 aa, ~312 kDa) is encoded by the human APC gene. This protein is involved in both tumor suppression and the… (More)

Topic mentions per year

Topic mentions per year

1988-2016
0204019882016

Papers overview

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Highly Cited
2008
Highly Cited
2008
The anaphase promoting complex or cyclosome (APC/C) is a ubiquitin protein ligase that, together with Cdc20 or Cdh1, targets cell… (More)
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Highly Cited
2007
Highly Cited
2007
The anaphase-promoting complex (APC), or cyclosome, is an E3 ubiquitin-protein ligase that collaborates with E2 ubiquitin… (More)
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Highly Cited
2006
Highly Cited
2006
The anaphase-promoting complex (APC) coordinates mitosis and G1 by sequentially promoting the degradation of key cell-cycle… (More)
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Highly Cited
2004
Highly Cited
2004
Skp2 and its cofactor Cks1 are the substrate-targeting subunits of the SCF(Skp2-Cks1) (Skp1/Cul1/F-box protein) ubiquitin ligase… (More)
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Highly Cited
2004
Highly Cited
2004
Rho family GTPases, particularly Rac1 and Cdc42, are key regulators of cell polarization and directional migration. Adenomatous… (More)
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Highly Cited
2004
Highly Cited
2004
The transcriptional coactivator beta-catenin mediates Wnt growth factor signaling. In the absence of a Wnt signal, casein kinase… (More)
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Highly Cited
2000
Highly Cited
2000
Adenomatous polyposis coli (APC) tumor suppressor protein has been shown to be localized near the distal ends of microtubules… (More)
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Highly Cited
2000
Highly Cited
2000
Mutational inactivation of the APC gene is a key early event in the development of familial adenomatous polyposis and colon… (More)
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Highly Cited
1996
Highly Cited
1996
The adenomatous polyposis coli gene (APC) is mutated in familial adenomatous polyposis and in sporadic colorectal tumors, and its… (More)
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Highly Cited
1996
Highly Cited
1996
The Wnt-1 proto-oncogene induces the accumulation of beta-catenin and plakoglobin, two related proteins that associate with and… (More)
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