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APC gene
Known as:
Genes, APC
, DP2
, adenomatous polyposis coli
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Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial…
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National Institutes of Health
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Related topics
Related topics
49 relations
APC Gene Mut Anal Bld/T
APC protein, human
Adenocarcinoma of rectum
Adenocarcinoma of the large intestine
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2001
Review
2001
The ABC of APC.
N. Fearnhead
,
M. P. Britton
,
W. Bodmer
Human molecular genetics
2001
Corpus ID: 15682028
Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease characterized by the presence of adenomatous…
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Highly Cited
1998
Highly Cited
1998
Identification of c-MYC as a target of the APC pathway.
T. He
,
A. Sparks
,
+6 authors
K. Kinzler
Science
1998
Corpus ID: 30643431
The adenomatous polyposis coli gene (APC) is a tumor suppressor gene that is inactivated in most colorectal cancers. Mutations of…
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Highly Cited
1997
Highly Cited
1997
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
P. Morin
,
A. Sparks
,
+4 authors
K. Kinzler
Science
1997
Corpus ID: 26754292
Inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene initiates colorectal neoplasia. One of the biochemical…
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Highly Cited
1997
Highly Cited
1997
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
V. Korinek
,
Nick Barker
,
+5 authors
H. Clevers
Science
1997
Corpus ID: 33935423
The adenomatous polyposis coli (APC) tumor suppressor protein binds to β-catenin, a protein recently shown to interact with Tcf…
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Review
1996
Review
1996
Lessons from Hereditary Colorectal Cancer
K. Kinzler
,
B. Vogelstein
Cell
1996
Corpus ID: 18032613
Highly Cited
1996
Highly Cited
1996
Suppression of Intestinal Polyposis in Apc Δ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)
M. Oshima
,
J. Dinchuk
,
+6 authors
M. Taketo
Cell
1996
Corpus ID: 16412817
Highly Cited
1993
Highly Cited
1993
Association of the APC gene product with beta-catenin.
B. Rubinfeld
,
B. Souza
,
+5 authors
P. Polakis
Science
1993
Corpus ID: 37684059
Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and…
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Highly Cited
1993
Highly Cited
1993
Association of the APC tumor suppressor protein with catenins.
L. Su
,
B. Vogelstein
,
K. Kinzler
Science
1993
Corpus ID: 45679889
Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been…
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Highly Cited
1992
Highly Cited
1992
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.
Y. Miyoshi
,
H. Nagase
,
+7 authors
Y. Nakamura
Human molecular genetics
1992
Corpus ID: 15410877
We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas…
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Highly Cited
1988
Highly Cited
1988
Genetic alterations during colorectal-tumor development.
B. Vogelstein
,
E. Fearon
,
+7 authors
J. Bos
The New England journal of medicine
1988
Corpus ID: 34936982
Because most colorectal carcinomas appear to arise from adenomas, studies of different stages of colorectal neoplasia may shed…
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