APC gene

Known as: Genes, APC, DP2, adenomatous polyposis coli 
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial… (More)
National Institutes of Health

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Highly Cited
1998
Highly Cited
1998
The adenomatous polyposis coli gene (APC) is a tumor suppressor gene that is inactivated in most colorectal cancers. Mutations of… (More)
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Highly Cited
1998
Highly Cited
1998
Control of stability of beta-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a… (More)
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Highly Cited
1997
Highly Cited
1997
Inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene initiates colorectal neoplasia. One of the biochemical… (More)
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Highly Cited
1997
Highly Cited
1997
The adenomatous polyposis coli (APC) tumor suppressor protein binds to beta-catenin, a protein recently shown to interact with… (More)
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Highly Cited
1997
Highly Cited
1997
In a 4-cell stage C. elegans embryo, signaling by the P2 blastomere induces anterior-posterior polarity in the adjacent EMS… (More)
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Review
1996
Review
1996
that demonstrated tight linkage of the disease to markers on chromosome 5q21 (Bodmer et al., 1987; Leppert *The Johns Hopkins… (More)
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Highly Cited
1993
Highly Cited
1993
Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and… (More)
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Highly Cited
1992
Highly Cited
1992
We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas… (More)
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Highly Cited
1992
Highly Cited
1992
Germ-line mutations of the APC gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominantly inherited… (More)
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Highly Cited
1991
Highly Cited
1991
Recent studies suggest that one or more genes on chromosome 5q21 are important for the development of colorectal cancers… (More)
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