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APC gene

Known as: Genes, APC, DP2, adenomatous polyposis coli 
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial… 
National Institutes of Health

Papers overview

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Review
2001
Review
2001
Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease characterized by the presence of adenomatous… 
Highly Cited
1998
Highly Cited
1998
The adenomatous polyposis coli gene (APC) is a tumor suppressor gene that is inactivated in most colorectal cancers. Mutations of… 
Highly Cited
1997
Highly Cited
1997
Inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene initiates colorectal neoplasia. One of the biochemical… 
Highly Cited
1997
Highly Cited
1997
The adenomatous polyposis coli (APC) tumor suppressor protein binds to β-catenin, a protein recently shown to interact with Tcf… 
Review
1996
Highly Cited
1993
Highly Cited
1993
Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and… 
Highly Cited
1993
Highly Cited
1993
Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been… 
Highly Cited
1992
Highly Cited
1992
We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas… 
Highly Cited
1988
Highly Cited
1988
Because most colorectal carcinomas appear to arise from adenomas, studies of different stages of colorectal neoplasia may shed…