APC gene

Known as: Genes, APC, DP2, adenomatous polyposis coli 
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial… (More)
National Institutes of Health

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APC Gene Mut Anal Bld/TAPC protein, humanAdenocarcinoma of rectumAdenocarcinoma of the large intestine
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Highly Cited
1998
Highly Cited
1998
Identification of c-MYC as a target of the APC pathway.
The adenomatous polyposis coli gene (APC) is a tumor suppressor gene that is inactivated in most colorectal cancers. Mutations of… (More)
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Highly Cited
1998
Highly Cited
1998
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.
Control of stability of beta-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a… (More)
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Highly Cited
1997
Highly Cited
1997
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.
Inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene initiates colorectal neoplasia. One of the biochemical… (More)
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Highly Cited
1997
Highly Cited
1997
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
The adenomatous polyposis coli (APC) tumor suppressor protein binds to beta-catenin, a protein recently shown to interact with… (More)
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Highly Cited
1997
Highly Cited
1997
Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos
In a 4-cell stage C. elegans embryo, signaling by the P2 blastomere induces anterior-posterior polarity in the adjacent EMS… (More)
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Review
1996
Review
1996
Lessons from Hereditary Colorectal Cancer
that demonstrated tight linkage of the disease to markers on chromosome 5q21 (Bodmer et al., 1987; Leppert *The Johns Hopkins… (More)
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Highly Cited
1993
Highly Cited
1993
Association of the APC gene product with beta-catenin.
Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and… (More)
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Highly Cited
1992
Highly Cited
1992
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.
We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas… (More)
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Highly Cited
1992
Highly Cited
1992
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene.
Germ-line mutations of the APC gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominantly inherited… (More)
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Highly Cited
1991
Highly Cited
1991
Identification of FAP locus genes from chromosome 5q21.
Recent studies suggest that one or more genes on chromosome 5q21 are important for the development of colorectal cancers… (More)
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