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APC gene

Known as: Genes, APC, DP2, adenomatous polyposis coli 
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial… Expand
National Institutes of Health

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APC Gene Mut Anal Bld/TAPC protein, humanAdenocarcinoma of rectumAdenocarcinoma of the large intestine
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer.
Aberrant Wnt/β-catenin signaling has often been reported in different cancers, particularly colorectal cancer (CRC), and this… Expand
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Review
2018
Review
2018
Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer
Colorectal cancer (CRC) is one of the major health threats in developed countries. Changes in dietary components, such as more… Expand
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Review
2018
Review
2018
Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives
Purpose of ReviewParkinson’s disease (PD) is a complex neurodegenerative disorder, the aetiology of which is still largely… Expand
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Review
2017
Review
2017
Osteosarcoma: Molecular Pathogenesis and iPSC Modeling.
Rare hereditary disorders provide unequivocal evidence of the importance of genes in human disease pathogenesis. Familial… Expand
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Highly Cited
1998
Highly Cited
1998
Identification of c-MYC as a target of the APC pathway.
The adenomatous polyposis coli gene (APC) is a tumor suppressor gene that is inactivated in most colorectal cancers. Mutations of… Expand
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Highly Cited
1997
Highly Cited
1997
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene initiates colorectal neoplasia. One of the biochemical… Expand
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Highly Cited
1997
Highly Cited
1997
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
The adenomatous polyposis coli (APC) tumor suppressor protein binds to β-catenin, a protein recently shown to interact with Tcf… Expand
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Highly Cited
1993
Highly Cited
1993
Association of the APC gene product with beta-catenin.
Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and… Expand
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Highly Cited
1992
Highly Cited
1992
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.
We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas… Expand
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Highly Cited
1988
Highly Cited
1988
Genetic alterations during colorectal-tumor development.
Because most colorectal carcinomas appear to arise from adenomas, studies of different stages of colorectal neoplasia may shed… Expand
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