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APC gene

Known as: Genes, APC, DP2, adenomatous polyposis coli 
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial… 
National Institutes of Health

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APC Gene Mut Anal Bld/TAPC protein, humanAdenocarcinoma of rectumAdenocarcinoma of the large intestine

Papers overview

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Highly Cited
2007
Highly Cited
2007
Two common chromosome 8q24 variants are associated with increased risk for prostate cancer.
Two variants (rs1447295/DG8S737) of chromosome 8q24 were recently reported to be associated with increased risk of prostate… 
Highly Cited
2003
Highly Cited
2003
The CHEK2*1100delC variant acts as a breast cancer risk modifier in non-BRCA1/BRCA2 multiple-case families.
The frame-shifting mutation 1100delC in the cell-cycle-checkpoint kinase 2 gene (CHEK2) has been reported to be associated with… 
Highly Cited
2002
Highly Cited
2002
Germline mutation of ARF in a melanoma kindred.
Familial melanoma predisposition is associated with germline mutations at the CDKN2A/ARF locus in up to 40% of families. The… 
Highly Cited
1997
Highly Cited
1997
Interaction of the DF3/MUC1 Breast Carcinoma-associated Antigen and β-Catenin in Cell Adhesion*
The DF3/MUC1 mucin-like glycoprotein is aberrantly overexpressed in human breast carcinomas. The functional role of DF3 is… 
Highly Cited
1997
Highly Cited
1997
DAP‐1, a novel protein that interacts with the guanylate kinase‐like domains of hDLG and PSD‐95
The human homologue of the Drosophila discs large tumour suppressor protein (hDLG) and closely related proteins such as… 
Highly Cited
1996
Highly Cited
1996
Alteration of beta-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients.
It has been found that beta-catenin, a key regulator of the cadherin-mediated cell adhesion system, forms complexes with… 
Highly Cited
1995
Highly Cited
1995
Evidence for u.v. induction of CDKN2 mutations in melanoma cell lines.
The CDKN2 gene, encoding the cyclin dependent kinase inhibitor p16, is a tumour suppressor gene involved in melanoma and maps to… 
Highly Cited
1990
Highly Cited
1990
Familial defective apolipoprotein B-100: detection in the United Kingdom and Scandinavia, and clinical characteristics of ten cases.
Highly Cited
1988
Highly Cited
1988
Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli
Recent studies have suggested a critical role of specific gene loss in several embryonic tumours1–6 and certain adult cancers7–12… 
Highly Cited
1979
Highly Cited
1979
A word-naming deficit in nonfamilial sinistrals? Laterality effects of vocal responses to tachistoscopically presented letter strings
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